Human airway epithelium
Decreased Neuraminidase Activity Is Important for the Adaptation of H5N1 Influenza Virus to Human Airway Epithelium
... man airway epithelium, we passaged the parental viruses in paral- lel in the absence of ...to human airway epithelium because of the reduced NA enzyme activity (achieved either by ...
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RFX3 Modulation of FOXJ1 regulation of cilia genes in the human airway epithelium
... the human airway epithelium? Sec- ond, what roles do the transcriptional regulators NOTO and/or RFX play in human airway ciliated cell differenti- ation? To answer these questions, we ...
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Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity
... primary human airway BC div- ide only a limited number of times before entering a state of replicative ...primary human epithelial cells (including human airway epithelium) can ...
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Vulnerability of the human airway epithelium to hyperoxia Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress
... the human catalase cDNA, levels of catalase were significantly increased in human airway epithelial cells and this was associated with increased survival of the cells when exposed to ...the ...
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Anti H7N9 avian influenza A virus activity of interferon in pseudostratified human airway epithelium cell cultures
... Primary human airway epithelium (HAE) cells can be further differentiated into polarized HAE cells when they are subjected to air–liquid interface (ALI) culture for 4 to 6 ...vivo human ...
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Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium
... small human airway epithelium, including glutamate decarboxylase, GABA receptors, transporters and catabolism ...small airway epithelium of healthy smokers ...in airway ...
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A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium
... specialized airway epithelial cells that occur as solitary cells or as clus- ters called neuroepithelial bodies (NEB) ...respiratory epithelium, laryngeal mucosa [2] and throughout the entire respiratory ...
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Human antigen R enhances the epithelial-mesenchymal transition via regulation of ZEB-1 in the human airway epithelium
... Several transcription factors, such as Snail, Slug, ZEB-1, ZEB-2, Twist and β -catenin, have been identified as key regu- lators of EMT and have been extensively reported [25 – 29]. In Mahmood MQ ’ s study [25], β ...
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Infection of Ciliated Cells by Human Parainfluenza Virus Type 3 in an In Vitro Model of Human Airway Epithelium
... cultures. Human airway tracheobronchial epithelial cells were ob- tained from airway specimens resected at lung transplantation under UNC In- stitutional Review Board-approved protocols by the UNC ...
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Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium
... then traffics to the apical side of the cell, where it can be shed into the extracellular space (33). Interestingly, cleavage of HAI-1 by a membrane type 1 matrix metalloproteinase (MMP-1) promotes matriptase’s ...
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Infection of Human Airway Epithelium by Human and Avian Strains of Influenza A Virus
... of human bronchial epithelial cells, it was recently shown that sialidase treatment reduced infection by human PIV1 but not by influenza virus ...the airway. HAE cells accurately recapitulate ...
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Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium
... tests. Human bronchial tissues were obtained from the 2-4 bronchi of the lobe resected at surgery, avoiding areas involved by ...of human bronchial ...
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Myxovirus interaction with the human airway epithelium
... (11). Human PIV3 C protein inhibits both type I and type II IFN by blocking STAT1 phosphorylation, although it is unknown whether this is a direct C-STAT1 interaction or because C targets JAK1, 2 or TYK2 leading ...
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The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium
... normal human bronchial epithelial cells (CC-2541; Lonza, Walkersville, MD) were grown in Clonetics™ BEGM BulletKit (CC-3170, Lonza) supple- mented with the following growth supplements: bovine pituitary extract, ...
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Competitive Fitness of Influenza B Viruses with Neuraminidase Inhibitor-Resistant Substitutions in a Coinfection Model of the Human Airway Epithelium
... the human upper respiratory tract, which is the pri- mary site of influenza virus infection and a major source of respi- ratory droplets that mediate transmission ...of human infection by NAI-susceptible ...
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Role of Interferon in the Replication of Human Parainfluenza Virus Type 1 Wild Type and Mutant Viruses in Human Ciliated Airway Epithelium
... the human airway epithelium (HAE) that closely mimic the morphological and physiological features of the HAE in vivo are now well characterized (43, ...isolated human airway cells grown ...
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Adaptation of Human Parainfluenza Virus to Airway Epithelium Reveals Fusion Properties Required for Growth in Host Tissue
... includes human parainfluenza virus type 3 (HPIV3), cause the majority of childhood croup, bronchiolitis, and pneumonia ...differentiated human airway epithelium (HAE) cultures and in ...
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Glycocalyx Restricts Adenoviral Vector Access to Apical Receptors Expressed on Respiratory Epithelium In Vitro and In Vivo: Role for Tethered Mucins as Barriers to Lumenal Infection
... The human airway glycocalyx is complex, with the large O-glycosylated mucin glycoproteins being a major ...The human airway epithelium expresses multiple mucin mol- ecules, some of ...
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Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers
... the human lung has been to use infor- mation from gene manipulation in murine models to identify genes associated with mucin synthesis/secretion, and to evaluate these genes and their associated genes in samples ...
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Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells
... Unexpectedly, simvastatin also induced the expression of CCL20 (MIP-3α) and caspase-1 (Figure 4), independ- ent of IL-13. Although CCL20 is a pro-inflammatory cytokine that attracts natural killer (NK) cells and mem- ory ...
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