Human Alveolar Macrophages
Human alveolar macrophages produce a fibroblast like collagenase and collagenase inhibitor
... Human macrophages have been implicated in connective tissue remodeling; however, little is known about their direct effects upon collagen ...that human alveolar macrophages in culture ...
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Productive infection of isolated human alveolar macrophages by respiratory syncytial virus
... whether human alveolar macrophages supported RSV replication in ...vitro. Alveolar macrophages exposed to RSV demonstrated expression of RSV fusion gene, which increased in a ...
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Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages
... with human neutrophil ...that human alveolar macrophages in culture elaborate a metalloproteinase that degrades both native type V collagen and denatured ...
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Human alveolar macrophages: comparison of phagocytic ability, glucose utilization, and ultrastructure in smokers and nonsmokers
... in human alveolar macrophages in smokers and ...The macrophages were obtained by bronchopulmonary lavage and the studies were carried out in vitro in the absence of ...
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Functional consequences for primary human alveolar macrophages following treatment with long, but not short, multiwalled carbon nanotubes
... in recognition of lipopolysaccharide from Gram-negative bacteria) at 1 day following the 24-hour treatment with MWCNT-0.6 μ m; however, in contrast, the scavenger recep- tors MARCO, MSR-1, and CD36 (important in ...
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Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin 4
... To gain insights into the role of cell differentiation upon the capacity of IL-4 to suppress mononuclear phagocyte metalloproteinase production, we examined the effects of this cytokine [r] ...
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Expression and Use of Human Immunodeficiency Virus Type 1 Coreceptors by Human Alveolar Macrophages
... tissue macrophages is limited. Studies with human micro- glial cells of the brain have demonstrated the expression of CCR3 and CCR5, although recent data suggest a dominant role for CCR5 in infection (28, ...
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Specificity of opsonic antibodies to enhance phagocytosis of Pseudomonas aeruginosa by human alveolar macrophages
... macrophages. Macrophages were obtained by lung lavage of normal adult smoker and nonsmoker volunteers and were maintained as in vitro cell monolayers. Both immune sIgA and IgG agglutinating antibodies were ...
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Pinocytosis by Human Alveolar Macrophages COMPARISON OF SMOKERS AND NONSMOKERS
... Alveolar macrophages were obtained from human volunteers, smokers and nonsmokers, by bronchial lavage through a fiberoptic bronchoscope. Cells were incubated in a chemically defined medium containing ...
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Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity
... induce macrophages to adopt phenotypes linked with tissue remodeling and repair; this phenotype is gener- ally recognized as “ alternatively activated ” or M2 pheno- type [3 – ...
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12 o Tetradecanoyl phorbol 13 acetate differentiated U937 cells express a macrophage like profile of neutral proteinases High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G
... with human alveolar macrophages, U937 cells also released a protein identical to the collagenase inhibitor produced by human skin fibroblasts, a molecule not associated with ...
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Interactions between dendritic cells and mycobacterium tuberculosis
... Mtb, macrophages release a wide range of inflammatory cytokines and ...by macrophages following infection with ...by human alveolar macrophages (Pace et a l, 1999), the monocyte cell ...
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Human Alveolar Macrophage derived Chemotactic Factor for Neutrophils: STIMULI AND PARTIAL CHARACTERIZATION
... of alveolar macrophages in modulating the migration of neutrophils to the lung, normal human alveolar macrophages obtained from volunteers by bronchopulmonary lavage, were exposed for ...
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Alveolar macrophage derived chemotactic factor: kinetics of in vitro production and partial characterization
... Alveolar macrophages are the initial phagocytic cells that encounter foreign material and particulates deposited in the terminal ...Normal human alveolar macrophages (AM) were studied ...
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Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25 dihydroxyvitamin D3
... by human alveolar macrophages (AM) from normals and sarcoid patients in suspension immediately after bronchoalveolar lavage in the presence and absence of the triggering agent, phorbol myristate ...
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Synthesis of Dipalmitoyl Lecithin by Alveolar Macrophages
... by alveolar macrophages, heterophils, and lung slices, 37% was in the 1 ...fluid, alveolar macrophages, and lung of rabbit 8-12 hr after a single intravenous injection of palmitic-1- 14 C ...
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S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureusdetection
... in human bronchial and lung epithelial cells and cell lines as well as in alveolar macrophages of healthy individuals and patients with COPD at different stages of the ...
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Induction of Aryl Hydrocarbon Hydroxylase in Human Pulmonary Alveolar Macrophages by Cigarette Smoking
... 0.095±0.024 U/10 6 cells. A former cigarette smoker was lavaged on five occasions. Enzyme activity during two lavages 4 mo apart were 0.010 and 0.009 U/10 6 cells, respectively. 1 wk after smoking was resumed, the enzyme ...
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Role of transforming growth factor β isoforms in the pathogenesis of pulmonary fibrosis
... in alveolar walls is variable, but when the fibrotic pattern predominates relatively few inflammatory cells are ...The alveolar walls are thickened and electron microscopy reveals that they not only contain ...
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Potential Mediator of Inflammation: PHAGOCYTE DERIVED OXIDANTS SUPPRESS THE ELASTASE INHIBITORY CAPACITY OF ALPHA1 PROTEINASE INHIBITOR IN VITRO
... myeloperoxidase may have also played a role in a 1 -Pi inactivation since serum EIC was partly protected by azide, cyanide, or the depletion of extracellular chloride. Indeed, in a cell-free system consisting of purified ...
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