human apo A-I
Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A I Presentation of a new animal model and mechanistic studies in human Apo A I transgenic and control mice
... increased apo A-I secretion from primary hepatocytes isolated from animals on the high fat ...increased apo A-I production was not associated with any increase in hepatic or intestinal ...
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Apolipoprotein A I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production
... of human apo A-I in transgenic mice protects against the development of fatty streak lesions (3) and de- creases the extent of atherosclerosis in apo E–deficient (4, 5) and ...
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Apo A I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
... experiments, apo E–deficient mice (7) and apo E–deficient/human apo A-I transgenic mice (5) were obtained from an existing colony of mice at The Rockefeller ...C57BL/6 apo ...
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Opposite regulation of human versus mouse apolipoprotein A I by fibrates in human apolipoprotein A I transgenic mice
... in apo E knockout mice (49, ...of apo A-I gene expression could also exert a profound and beneficial impact on human ...the human apo A-I gene has been demonstrated to ...
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Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism Studies in transgenic mice
... hypertriglyceridemic human apo CIII transgenic mice lowered HDL-cholesterol (HDL-C) 48% and apolipoprotein (apo) A-I 40%, decreased HDL size (particle diameter from ...increased apo ...
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Measurement of very low density and low density lipoprotein apolipoprotein (Apo) B 100 and high density lipoprotein Apo A I production in human subjects using deuterated leucine Effect of fasting and feeding
... g/ml) apo B-100 at plateau. VLDL apo B-100 production was greater, and LDL ...g/ml) apo B-100 production was less in the fed compared with the fasted state ...lipoprotein apo A-I ...
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The Tangier disease gene product ABC1 controls the cellular apolipoprotein mediated lipid removal pathway
... of apo A-I–mediated lipid efflux (data not ...with human papil- lomavirus 16 genes E6 and E7 and a neomycin resistance selectable ...µg/mL apo A-I (Biode- sign International, Kennebunk, ...
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Increased apo A I and apo A II fractional catabolic rate in patients with low high density lipoprotein cholesterol levels with or without hypertriglyceridemia
... apolipoproteins, apo A-I and apo A-II, in 15 human subjects with low HDL-C, six with normal plasma TG levels (group 1) and nine with high TG (group 2), and compared them to 13 control subjects ...
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Retinoids increase human apo C III expression at the transcriptional level via the retinoid X receptor Contribution to the hypertriglyceridemic action of retinoids
... add apo C-III to the list of genes involved in lipoprotein metabolism, whose expression is con- trolled by ...of apo A-I and apo A-II, the major HDL apolipoproteins (31, ...the apo ...
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Serum prostacyclin stabilizing factor is identical to apolipoprotein A I (Apo A I) A novel function of Apo A I
... from human serum to a single protein with a molecular weight of 28,000 D by ...with human apolipoprotein A-I (Apo A-I), a major apolipoprotein of ...of Apo A-I is ...
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Prolonged postprandial responses of lipids and apolipoproteins in triglyceride rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele
... an apo e 4 allele than in e 3 homozygotes (6, 9), the meta-analysis of Dallongeville and associates (10) in 45 population samples from 17 countries has shown that the con- centration of plasma triglycerides is ...
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Preoperative serum apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients
... of Apo A-I, ALB, NLR, and HGB were further assessed in patient subgroups defined by IBCG risk ...for Apo A-I, ALB, NLR, and HGB ...elevated Apo A-I ( > ...low Apo ...
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Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
... rheumatology; apo A-I: Apolipoprotein A-I; apo E: Apolipoprotein E; BMI: Body mass index; CRF: Cardiovascular risk factor; c-SLE: Childhood-onset systemic lupus erytematosus; CVD: ...
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Structural relationship of human apolipoprotein B48 to apolipoprotein B100
... of apo B100 and apo B48 with antipeptides 2068-2091 and 2110-2129 detected a 16-KD fragment (residues 2016-2151) in the apo B100 digest and a fragment of identical size in the apo B48 ...
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During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein
... Hormonal adjuvant therapy of breast cancer is overall tumoristatic with cell death balancing a basal level of cell proliferation [24]. From a fundamental mechanistic standpoint, for resistance to develop in the long term ...
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Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles
... work human apo CIII transgenic (HuCIIITg) mice were found to have elevated triglyceride ...of apo CIII (human and mouse) per VLDL particle was 2 and ...Mouse apo E was decreased by 35 ...
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Anti Fas/APO 1 antibody mediated apoptosis of cultured human glioma cells Induction and modulation of sensitivity by cytokines
... of human malignant glioma cells to IFN gamma and TNF ...the human malignant glioma cell lines was susceptible to TNF alpha-induced ...of human glioma cells to Fas/APO-1 antibody-mediated ...
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Apolipoprotein C III(Lys58 Glu) Identification of an apolipoprotein C III variant in a family with hyperalphalipoproteinemia
... content. Apo C-III putatively inhibits lipolysis and the apo E mediated hepatic uptake of remnants from triglyceride rich ...the apo C-III ...
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A low fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates
... while apo A-I levels fell 23% from 139 +/- 22 to 107 +/- 22 mg/dl (both P less than ...Mean apo A-II levels did not ...of apo A-I increased 11% from ...and apo A-I levels ...
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Isolation and characterization of apolipoprotein B 48 and B 100 very low density lipoproteins from type III hyperlipoproteinemic subjects
... clearance, apo B-48 containing lipoproteins accumulate in the plasma of subjects with type III ...the apo B-100 VLDL fraction. The ability to separate apo B-100 VLDL from apo B-48 VLDL shows ...
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