Human beta-defensin 3
Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling
... Human beta-defensin 3 (hBD3), an antimicrobial peptide (AMP) expressed in epithelium in response to various stimulations including human papillomavirus infection, has recently been ...
12
Legionella pneumophila induces human beta Defensin-3 in pulmonary cells
... In the study presented, we demonstrate that L. pneumo- phila- induced hBD-3 expression was dependent on TLR2, TLR5 and TLR9 in human alveolar epithelial cells. The activation of JNK-pathway was identified ...
12
Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments
... treatment. Human β-defensin 3 (hBD3), possesses both antimicrobial and proregeneration ...on human periodontal ligament cells (hPDLCs) remain ...
13
Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity
... Abstract: Human beta-defensins (hBDs) are crucial factors of intrinsic immunity that function in the immunologic response to a variety of invading enveloped viruses, bacteria, and ...
12
Narrowing down the distal border of the copy number variable beta defensin gene cluster on human 8p23
... indels 3 to 7, indels 1 and 2 are located in the LCR and PCR also amplifies paralogs from loci not affected by CNV on chromosomes 4, 8, 11 and ...the human genome assembly GRCh37 (hg19) by ...
8
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
... pattern, human defensins are divided into two groups, alpha-defensins and ...lung. Beta-defensin-1 (DEFB1) is constituatively expressed in airway epithelia and plays an important role in mucosal ...
8
De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy and human beta-defensin 2 expression in intestinal epithelial cells
... Recent studies have begun to implicate sphingolip- ids in regulation of bacterial infections [1, 2]. Increas- ing evidence indicates the potential of autophagy in controlling infections by directing intracellular or ...
11
Regulation of bovine beta defensin expression
... in human vaginal epithelium is not modified by estrogen or progesterone alone, however both modulate the LPS-driven response (Han et ...smaller. Human endometrial epithelial cells significantly upregulate ...
283
Original Article Dust mite vaccine enhances airway antibacterial host defense by up-regulating beta defensins in asthmatic mice
... [24]. Human beta defensin 2 (HBD-2) is the chief component of airway innate immunity, which is the first human defensins inducible expression by inflammation and ...mouse beta ...
9
Expression of Beta Defensin Genes in Frozen Thawed and Cultured Immortalised Human Corneal Epithelial Cell Line
... Human beta defensins (hBD) are important host defence molecules at the ocular ...the beta defensin genes (DEFB) expression in immortalised human corneal epithelial cell line (HCE-2) has ...
5
Original Article Expression of hBDs in gingival tissue in patients with cleft alveolus
... (human beta defensin) and clinical indexes in gingival tissue in patients with cleft alveolar who also suffering from periodontitis, 35 patients with cleft alveolar (age range from 12-19 years) and ...
9
Human beta defensin 2 is a salt sensitive peptide antibiotic expressed in human lung
... for human b -defensin 2 (hBD-2). The b -defensin specific cysteine pattern was used to per- form a “basic local alignment search tool” search at an expressed se- quence tag database (SmithKline ...
8
Original Article Inhibitory effect of recombinant human beta-defensin-2 on angiogenesis and inflammatory factors of rat model of endometriosis
... VEGF is one of the most critical stimulating factors. It is verified that VEGF may increase in the early stage of EMS. The concentration of VEGF in peritoneal fluid of patients with EMS is obviously higher than that of ...
8
Human beta defensin 1: an antimicrobial peptide of urogenital tissues
... quencing was performed at the UCLA Peptide Sequencing Facility. Immunolocalization of human b -defensin-1 peptide. Rabbit poly- clonal antiserum to HBD-1 was produced by immunization with the 39 aa rHBD-1. ...
11
Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool
... cells/200 µ L per well) into 96-well microtiter tissue culture plates for 24 hours in triplicate. The reduction in the prolifera- tion of the cells was evaluated by the 3-[4.5-dimethylthiazol-2 ...
17
Immunogenicity of a Bovine Herpesvirus 1 Glycoprotein D DNA Vaccine Complexed with Bovine Neutrophil Beta-Defensin 3
... and human CCR6-expressing cells (42) and of mBD4 (the mouse ortholog of human  -defensin 2) for human CCR2-expressing cells has been demonstrated ...⫽ 3) were cultured for 24 h in ...
12
Original Article Human beta-defensin 2 promotes the proliferation of lung cancer cells through ATP-binding cassette transporter G2
... [3] Janssens W, Nuytten H, Dupont LJ, Van Eldere J, Vermeire S, Lambrechts D, Nackaerts K, Decramer M, Cassiman JJ, Cuppens H. Ge- nomic copy number determines functional ex- pression of β-defensin 2 in ...
6
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations
... from human neutrophilic granulocytes (HNP-1, 2, and 3), a homologous defensin from rabbit leukocytes (NP-1), and four unrelated cationic ...and 3 are identical except for a single ...
8
Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection
... T84 human colon IECs, the enterotoxin STb can induce redistribution and/or fragmentation of ZO-1, claudin-1, and occludin due to actin rearrange- ment [45, ...
14
Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae
... β defensin- 2 or ...β defensin-2 for 30 minute, and 1 mg/ml of human milk lysozyme for 30 minute, ...β defensin-2 or lysozyme, NTHi show blebbing of the membranes with extrusion of the ...
12