Human blood–brain barrier
Engineering the human blood-brain barrier in vitro
... For larger molecules and proteins, such as transferrin, insulin, and IgG, transport is usually receptor-mediated (RMT) or adsorptive-mediated (AMT) [2] (Fig. 1b). Ef- forts to deliver therapeutics through these pathways ...
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A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
... the brain is receptor-mediated transcytosis ...a brain endothelial cell, after which it undergoes internalization via endocytosis and is trafficked to the abluminal side, where it can be released and gain ...
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Endocannabinoids modulate human blood brain barrier permeabilityin vitro
... NADA was found to increase BBB permeability with evi- dence of cell damage. In support of these findings, NADA has been shown to cause concentration-dependent cytotoxicity in human, murine or rat hepatic stellate ...
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Human blood brain barrier leptin receptor Binding and endocytosis in isolated human brain microvessels
... pocytes in vivo in response to stimuli that include food intake (5) and insulin administration (6), and appears to serve as a signal of satiety. Increases in ob gene mRNA expression have been observed in mice and rats ...
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Human blood brain barrier receptors for Alzheimer's amyloid beta 1 40 Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
... of human brain capillaries. Human brain capillaries were isolated from small fragments of cerebral cortex obtained from surgi- cal resections from three adults with seizure disorder, as we ...
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Brain microvascular endothelial astrocyte cell responses following Japanese encephalitis virus infection in an in vitro human blood brain barrier model
... from human autopsy studies on whether JEV can indeed infect human brain endothelial cells and astrocytes (German et ...infect human brain endothelial cells and cross the ...from ...
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Zika virus crosses an in vitro human blood brain barrier model
... in human brain endothelial cells, including i-BECs, and is also enriched in brain microvessels compared to target brain tissue, potentially contributing to brain tropism of ...of ...
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The hCMEC/D3 cell line as a model of the human blood brain barrier
... of human brain microvessels ...the brain uptake of the anti-influenza compounds amantadine and rimantadine ...the human BBB in vivo ...
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Article #785
... of brain capillary epithelial cells and is responsible for limiting the brain penetration of a range of ...the blood-brain barrier, resulting in reduced extracellular efflux and ...
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Blood brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
... cross human brain micro- vascular endothelial cells (BMECs), a human blood-brain barrier (BBB) model system, at much greater effi- ciency than do ...of human BMECs was ...
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Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia
... Our study provides strong evidence for another patho- logical substrate which contributes to the development of dementia in post-stroke survivors, most of whom had vas- cular dementia. We found highly increased ...
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Mannitol and the blood-labyrinth barrier
... the blood brain barrier (BBB) to gentamicin with and without mannitol was studied by collecting 175 samples from 44 guinea pigs using concentrations relevant to human clinical ...and ...
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Trojan Horse Transit Contributes to Blood Brain Barrier Crossing of a Eukaryotic Pathogen
... Trojan horse phagocytes convey cryptococci across transcellular pores. Our confocal microscopy analysis (Fig. 2) provided direct evidence for a Trojan horse mechanism of BBB traversal, in contrast to prior indirect ...
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Viral Pathogen Associated Molecular Patterns Regulate Blood Brain Barrier Integrity via Competing Innate Cytokine Signals
... the human treatment literature, however, is that patients have typically developed neuroinvasive disease be- fore treatment; this caveat, combined with the broad systemic effects of IFN therapy, limits our ...
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Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans
... fungal human pathogen that causes meningitis in a predominantly immunocompromised population ...the blood-brain barrier (BBB) ...primary human brain microvascular endothelial ...
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Breast cancer brain metastases: biology and new clinical perspectives
... of brain metastases (BM) has become a major limitation of life expectancy and quality of life for many breast cancer ...as human epidermal growth factor receptor 2-positive and triple-negative ...the ...
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What is the blood brain barrier (not)?
... not human) oligodendrocytes are particularly susceptible to such lysis since they express significantly lower levels of membrane complement regulators (such as CD35, CD46, CD55 and 59) compared to other nucleated ...
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The blood brain barrier in neuropsychiatric disorders
... for brain-wide knockdown of ...entire brain produced permeability of the BBB that resulted in impairments in learning and memory and increased ...in brain endothelial ...improve brain ...
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Molecular mechanisms of neuroinvasion by monocytes macrophages in HIV 1 infection
... by brain cells, among which are soluble frac- talkine (Fkn) and CXCL12, supports a slow but continuous entry of monocytes and macrophages into the central nervous ...the blood brain barrier ...
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Basement membrane and blood–brain barrier
... The BBB plays essential roles in brain homeostasis under physiological conditions and disease pathogen- esis/progression under pathological conditions. Recent studies strongly suggest that the BM also actively ...
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