Human brain endothelial cell
Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans
... fungal human pathogen that causes meningitis in a predominantly immunocompromised population ...primary human brain microvascular endothelial cells (HBMEC) are now available for BBB studies, ...
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PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies
... across brain endothelium and examine the mechanism of nanoparticle ...a human brain endothelial cell line, cytotoxicity assays, fluorescence-tagged nanocarriers, fluorescence-activated ...
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A2A adenosine receptor modulates drug efflux transporter P glycoprotein at the blood brain barrier
... As cell lines do not always reproduce all the characteristics of primary cells, we next examined the effect of Lexiscan and NECA treatment on P-gp expression in primary human brain endothe- lial ...
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MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
... to brain endothelial cells, the blood-brain barrier main component, is a critical step in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis ...selectins, cell adhesion ...
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Human blood brain barrier receptors for Alzheimer's amyloid beta 1 40 Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
... of the HBMEC monolayer suggests that all specific high-affin- ity binding sites at normal human BBB may be located at the apical side, similar as for insulin (30). The polarity of the BBB in present HBMEC model ...
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Brain microvascular endothelial astrocyte cell responses following Japanese encephalitis virus infection in an in vitro human blood brain barrier model
... from human autopsy studies on whether JEV can indeed infect human brain endothelial cells and astrocytes (German et ...infect human brain endothelial cells and cross the ...
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The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
... porcine brain endothelial ...with cell lines from the same species, since those studies already exist in the ...mouse cell line has already been compared to that of primary mouse [40] and por- ...
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Angiotensin receptors and β catenin regulate brain endothelial integrity in malaria
... to endothelial cells in the brain, disruption of the blood-brain barrier, and cerebral ...the endothelial disruptions underlying this complication, which is responsible for the majority of ...
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A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier
... (3-D) cell culture model of human BBB microvascular endothelial cells and to apply this model to the study of RNA ...used human brain microvascular endothelial cells (HBMEC) (9), ...
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The hCMEC/D3 cell line as a model of the human blood brain barrier
... multiple endothelial membrane proteins, including ezrin, moesin, and actin to form honeycomb cortical plaques beneath the meningococcal ...Par3/Par6/PKCζ endothelial po- larity ...eukaryotic cell ...
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Anaplasma phagocytophilum-Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells
... the endothelial cell ...vascular endothelial cells (9) and nonbrain microvascular cells (7, 9) by altering actin rearrange- ments (F-actin polymerization/stress fiber formation) through Rho and Rac ...
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Post mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells
... Several lines of evidence suggest that early diagnosis of GAE due to B. mandrillaris may help successful therapy. This is supported by recent studies of Deetz et al. (2003), who have shown that early initiation of ...
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Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendo- thelial migration of human breast cancer cell lines
... cancer cell lines across a tight barrier of primary human brain microvascular endothelia and an associated matrigel layer, and that this was at least partly mediated by MMPs (Figure ...three ...
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Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
... and human ECs, let us to interpret the matching genes as being the most important, obtaining 5 significantly regu- lated genes (Table ...tumor cell clots leading to thrombotic occlusion of blood vessels ...
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Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity
... increase in human brain microvascular endothelial cell metabolic activity.. Dufailu, Jafar Mahdavi, Dlawer A.[r] ...
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Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co cultured with Plasmodium falciparum field isolates
... of action (contact, cytoadherence and/or soluble factors). RBC parasitized-3D7 strain (in vitro maintained culture) and uninfected RBC were used respectively as positive and negative controls for both adherence and ...
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An immortalized human fibroblast cell line is permissive for human cytomegalovirus infection.
... Other cell lines, such as human brain endothelial cells 24, 28, human umbilical vein endothelial cells 14, 31, 33, 38, a teratocarcinoma cell line 23, cultures of human macrophages and m[r] ...
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CNS endothelium expression of ADAM 17 and its role in multiple sclerosis pathogenesis
... non-barrier endothelial cells such as placental cells, which have to allow the exchange of substances between mother and child, have a TEER of 22-52 Ocm2 (Jinga et ...The brain still requires nutrients and ...
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Polysialic acid is released by human umbilical vein endothelial cells (HUVEC) in vitro
... In an approach to investigate a biochemical func- tion of polySia, the degradation of polySia by endoN resulted in an increased migration capacity of HUVEC in vitro (Fig. 3b). Since VEGF and bFGF are produced and ...
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CXC and CC Chemokine Receptors on Coronary and Brain Endothelia
... Materials and Methods: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC) and coronary artery endothelial cells (CAEC).. in vitro and cryostat s[r] ...
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