HUMAN COLON-CANCER
Par 4 Sensitizes Human Colon Cancer Cells to Chemoradiotherapy
... the colon and rectum remain a leading cause of death ...rectal cancer, chemo-radiotherapy (CRT) is given prior to surgery to provide a greater chance of sphincter sparing surgery and lower the incidence of ...
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PHYTOCHEMICAL SCREENING AND IN VITRO ANTICANCER ACTIVITY OF EXTRACTS OF TECTARIA CICUTARIA
... various Human Cancer Cell Lines at Tata Memorial Centre - Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai, ...India. Human Leukemia Cell Line K562, ...
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Original Article Benzaldehyde levofloxacin schiff baseinduced apoptosis of human hepatocarcinoma cells
... cells, human breast cancer MB-231 cells, human colon cancer HCT-116 cells, human hepatocarcinoma HEPG-2 cells, mouse bone marrow mesenchymal stem cells (BMSCs) in ...the ...
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Dendritic cells pulsed with generated tumor cell lysate from Phyllanthus amarus Schum & Thonn induces anti tumor immune response
... in cancer im- ...16 human colon cancer and MCF-7 human breast cancer cell lines, create a col- lection of tumor-associated antigens (TAAs) that could activate DCs and evaluate ...
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Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
... in human colon cancer or represent classical tumor suppressor genes ...in cancer (6), can occur prior to tumor formation in normal cells (see also Supplemental Table 1; supplemental material ...
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P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
... Human colon cancer HT29 cells, lung cancer A549 cells, breast cancer MCF-7, SKBR3, T74D and MDA- MB-231 cells, osteosarcoma U2OS and SaOS cells, murine chemoresistant JC cells, ...
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Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cells
... Figure 5: Bcl-2 is a primary resistance factor of PKC412 in CRC cells. HT-29 cells (A and B) or primary human colon cancer cells (Line-1, C) were treated with applied concentrations of PKC412 (0.5/1 ...
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Calcein-effluxing human colon cancer cells are enriched for self- renewal capacity and depend on β-catenin
... resected colon cancers, though its intratumoral distribution of nuclear expression is heterogeneous and associated with a poor prognosis [20, ...[22-24]. Colon cancer cells with increased Wnt ...
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Wogonoside prevents colitis-associated colorectal carcinoge- nesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/ Akt pathway
... associated cancer and delineated the potential ...and cancer cell proliferation at tumor ...of human colon cancer cells in the inflammatory ...of human colon cancer ...
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Original Article Increased expression of O-GlcNAc transferase (OGT) is a biomarker for poor prognosis and allows tumorigenesis and invasion in colon cancer
... with cancer initiation, progression, invasion, and ...in colon cancer tumorigeneses remains ...in human colon cancer tissue compared with adjacent normal tissue, and cases with ...
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Advancing clinical oncology through genome biology and technology
... of cancer types. Collectively these projects, including The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consor- tium (ICGC), are characterizing the genomes and epigen- omes of ...
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Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
... cells, NF-κB is constitutively active and located in the nucleus due to incessant stimulation of the IKK pathway that degrades Iκβ, while in some other cases, the Iκβ gene is mutated and dysfunctional [57-60]. As a ...
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PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy
... prostate cancer growth and enhanced chemosensitivity to docetaxel ...prostate cancer cell survival [9]. However, in colon cancer patients who receive adjuvant chemotherapy after tumor ...
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Autocrine production of IL 11 mediates tumorigenicity in hypoxic cancer cells
... tant oncogenic role in PC3 cells (data not shown). In contrast, rhIL-11 did increase STAT3 phosphorylation in HCT116 and RCC4 cells, indicating that distinct transcriptional elements may be activated by IL-11 in ...
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Study of peritoneal elastic lamina invasion and extramural venous invasion in stage 2 colorectal carcinoma
... They have mutation in DNA mismatch repair genes most commonly MLH1 (MutL Homolog 1), MSH2 (MutS protein Homolog 2), MSH6 (MutS Homolog 6) and PMS2(Post Meiotic Segregation Increased, S.Cerevisiae ,2) (3)(5) . The first ...
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A central role for TRPS1 in the control of cell cycle and cancer development
... Normal tissue architecture and function is maintained through strict limitations on cell number, which is achieved via stringent cell cycle regulation. [51] Indeed, the mechanism(s) governing cell cycle transitions is ...
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Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer
... III colon cancer of HNPCC families in comparing patients treated with and without adjuvant 5FU (70 % 5-year sur- vival for both the group that received adjuvant therapy and the group that did not) ...
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PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors
... of cancer-dominant PKM2 is increased by polypyrimidine tract-binding protein 1 (PTBP1), which is a splicer of the PKM ...in colon tissue except muscle and very frequently down-regulated in 75 clinical ...
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TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer
... The degradation of ECM is a critical step in tumor inva- sion and metastasis. Matrix metalloproteases (MMPs), a family of zinc-dependent endopeptidases, play a major role in the degradation of ECM components [32,33]. ...
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CD133 CD24 lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype
... RNA was isolated from tumor cells. The quality of RNA was analyzed on a 2100 Bioanalyzer (Agilent Technologies, Santa Clara, CA) and assured by a RNA Integrity Number (RIN) ≥ 7. The Human Gene 2.0ST array ...
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