Human Cytomegalovirus
Peptide inhibition of human cytomegalovirus infection
... Background: Human cytomegalovirus (HCMV) is the most prevalent congenital viral infection in the United States and Europe causing significant morbidity and mortality to both mother and ...including ...
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Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAs
... the human cytomegalovirus AD169 genome for miRNAs using a bioinformatics ...chimpanzee cytomegalovirus and several strains of human ...from human cytomegalovirus-infected cells ...
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Restriction of Human Cytomegalovirus Infection by Galectin-9
... ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. While HCMV infection is generally asymptomatic in the immunocompetent, it can have devastating consequences in those with ...
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Quantitative Analysis of Latent Human Cytomegalovirus
... Human cytomegalovirus (CMV) is a medically important betaherpesvirus carried by a majority of individuals, where it is a leading cause of opportunistic and congenital disease ...a human pathogen, yet ...
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A novel mechanism for persistence of human cytomegalovirus in macrophages.
... Human cytomegalovirus (HCMV) infection of monocyte-derived macrophages (MDM) results in delayed and nonlytic productive viral growth. During late stages of replication, infectious virus remains cell ...
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The IκB Kinases Restrict Human Cytomegalovirus Infection
... is human cytomegalovirus (HCMV), a prevalent opportunistic betaherpesvirus that establishes latent infection and persists in the host indefinitely (1, ...largest human herpesvirus, has an ⬃ 235-kb ...
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Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma
... ABSTRACT Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital infections that can lead to severe birth ...that human semi- nal plasma (SP; the cell-free supernatant of semen) ...
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Characterization of the transcripts of human cytomegalovirus UL144
... HCMV: human cytomegalovirus; HVEM: herpesvirus entry mediator; ORF: open reading frame; TNFR: tumor necrosis factor receptor; HELF: Human embryonic lung fibroblast; PFU: plaque forming units; IE: ...
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Strain-Specific Neutralization of Human Cytomegalovirus Isolates by Human Sera
... Human cytomegalovirus (HCMV) remains a significant pathogen in individuals with an immature or compromised immune system. In contrast, infection of immunocompetent persons has had limited consequences in ...
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Human Cytomegalovirus oriLyt Sequence Requirements
... Human cytomegalovirus (HCMV) infection is endemic throughout human populations (1). The lytic phase of HCMV infection often poses life-threatening diseases in immunocom- promised individuals, ...
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Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection
... with human cytomegalovirus (HCMV) were more viable than uninfected cells during glucose starvation, suggesting that an alternate carbon source was ...
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Human cytomegalovirus UL102 gene.
... Human cytomegalovirus (HCMV) requires eleven distinct loci for origin-dependent DNA replication (25, 26). These loci were identified by using a cotransfection-replication assay sim- ilar to the procedure ...
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The Transcriptome of Latent Human Cytomegalovirus
... latent human cytomegalovirus (HCMV) transcriptome has been ex- tremely difficult to define due to the scarcity of naturally latent cells and the com- plexity of available ...
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Antisense Transcription in the Human Cytomegalovirus Transcriptome
... Human cytomegalovirus (HCMV) infections are prevalent in human populations and can cause serious diseases, especially in those with compromised or immature immune ...
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Inhibition of CD1 Antigen Presentation by Human Cytomegalovirus
... Other human her- pesviruses have been shown previously to affect group 2 CD1 molecules (34, 38, 43), for which the inhibition of recirculation and the accumulation of CD1d could also be ...
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Human cytomegalovirus UL76 induces chromosome aberrations
... Human embryonic lung cells (HEL299, ATCC), COS-1 cells, and human glioblastoma U-373 MG cells were maintained in Eagle's MEM supplemented with 10% fetal bovine serum (FBS). Methods for the construction, ...
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Cytomegalovirus "missing" capsid protein identified as heat-aggregable product of human cytomegalovirus UL46.
... This report describes experiments that were done to identify and characterize the protein product of the HCMV UL46 open reading frame. Our interest in this ORF stemmed from its positional homology with HSV UL38, which ...
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Mouse Cytomegalovirus Crosses the Species Barrier with Help from a Few Human Cytomegalovirus Proteins
... in human cells may have gone undetected were it not for the use of the mouse cell line 227, in which the ND10-associated Daxx has been genetically ablated ...in human cells, Daxx is interferon upregulated ...
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Human Cytomegalovirus UL38 Protein Blocks Apoptosis
... slow-replicating human cytomega- lovirus (HCMV) blocks premature death of host cells prior to completion of the infection ...in human fibroblasts, failed to accumulate viral DNA to wild-type levels, and ...
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Comparative sequence analysis of human cytomegalovirus strains
... Amino acid sequence comparison of selected areas within the gp58/116 gene of the laboratory strains AD169 and Towne with those of clinical isolate 1 PCR, 3 PCR, 4 PCR, 2 PCR, and 5 PCR c[r] ...
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