Human endogenous retrovirus
Expression analysis of the human endogenous retrovirus HERV K in human astrocytic tumors
... Background: The human endogenous retrovirus K (HERV-K) has been acquired by the genome of human ancestors million years ago. It is the most complete of the HERVs with transcriptionally active ...
6
Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3
... the human genome, human endogenous retroviruses (HERVs) are bona fide cellular genes despite their exogenous ...the human endogenous retrovirus HERV-K acts as a TATA- and ...
13
Human endogenous retrovirus K10 encodes a functional integrase.
... a human endogenous retrovirus K10 DNA fragment encoding integrase and expressed it as a fusion protein with Escherichia coli maltose-binding ...and human immunodeficiency virus type 1 LTR ...
5
Genomic Flexibility of Human Endogenous Retrovirus Type K
... Human endogenous retrovirus type K (HERV-K) proviruses are scattered throughout the human genome, but as no infectious HERV-K virus has been detected to date, the mechanism by which these ...
10
Paleogenomic Record of the Extinction of Human Endogenous Retrovirus ERV9
... The human genome, harboring the remnants of many extinct TE families, offers an extraor- dinary opportunity to investigate this ...an endogenous retrovirus repeatedly mobilized during primate ...
8
Human Endogenous Retrovirus Family HERV-K(HML-2) RNA Transcripts Are Selectively Packaged into Retroviral Particles Produced by the Human Germ Cell Tumor Line Tera-1 and Originate Mainly from a Provirus on Chromosome 22q11.21
... The human germ cell tumor line Tera-1 produces retroviral particles which are encoded by the human endogenous retrovirus family ...the human genome demonstrated that HML-2 RNA ...
9
Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer
... replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic ...certain human tumor cell lines have been shown to release ...
8
Analysis of Human Endogenous Retrovirus Expression in Multiple Sclerosis Plaques
... Twelve clade-specific primer pairs were tested for the GAG and ENV domains. The MSRV-ENV primer sequences were kindly provided by H. Perron [32]. Each primer pair was tested by performing qPCR with on the pooled RNA ...
9
Transactivation of elements in the human endogenous retrovirus W family by viral infection
... Specific analysis of transcripts from 7q21 showed that the proviral element was transactivated by influenza A/WSN/ 33 virus in all cell-lines tested. Surprisingly, in U937, virus infection elevated the levels of ...
11
Effects of Recombination Rate on Human Endogenous Retrovirus Fixation and Persistence
... (e.g., human immunodeficiency virus) represent a notable ex- ception to this general rule by infecting nondividing cells ...than human immunodeficiency virus ...
6
A Human Endogenous Retrovirus Suppresses Translation of an Associated Fusion Transcript, PLA2L
... novel human locus whose sequence is similar to that of cellular phospholipase ...NTera2D1 human teratocarcinoma cell line cDNA library by a differential hybridization screening proce- ...
5
Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors
... Identification of RT-coding genes in the human genome. In order to determine which HK2 proviruses can code for functional reverse transcriptase (RT), we analyzed the reading frames of RT genes carried by all known ...
18
HIV-1 Interacts with Human Endogenous Retrovirus K (HML-2) Envelopes Derived from Human Primary Lymphocytes
... Human endogenous retroviruses (HERVs) are viruses that have colonized the germ line and spread through vertical ...primary human lymphocytes of five different ...these endogenous retroviral ...
11
Human endogenous retrovirus K (HML 2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells
... Active type 2 proviruses produce Rec protein, which supports cell transformation in vitro and germ line carcin- oma in situ in transgenic mice [7,31]. Type 1 proviruses produce Np9 protein [4]. Both Rec and Np9 interact ...
6
Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription
... that human cytomegalovirus (HCMV) is highly prevalent in tumours of different ...expression. Human endogenous retroviruses (HERV) are also frequently active in tumours of different origin, and are ...
7
Identification and Characterization of Novel Human Endogenous Retrovirus Families by Phylogenetic Screening of the Human Genome Mapping Project Database
... codes motifs indicative of the presence of gag, pol, and env (Fig. 2 and 4); there was no evidence of other gene products. Al- though all three genes appeared similar in size to those of other retroviruses, suggesting ...
16
Comprehensive Analysis of Human Endogenous Retrovirus Transcriptional Activity in Human Tissues with a Retrovirus-Specific Microarray
... the retrovirus-specific microarray and to determine the relative levels of HERV ...normal human tissues ...different human tissues (brain, skin, liver, mammary gland, ovary, cervix, testes, and ...
12
Proviral Structure, Chromosomal Location, and Expression of HERV-K-T47D, a Novel Human Endogenous Retrovirus Derived from T47D Particles
... the human genome ...in human teratocar- cinoma cell lines (18, 19, 42), and gag and pol gene products of HERV-K(HML-2) family members have been demonstrated to be enzymatically active (12, 28, ...an ...
8
Inhibition of human endogenous retrovirus K by antiretroviral drugs
... effects of HIV [14]. This may be important since Abacavir and Zidovudine have better CNS penetration compared to the other NRTIs [15]. However Abacavir can cause a hypersensitivity syndrome which is strongly but not ...
13
A recurrent translocation is mediated by homologous recombination between HERV-H elements
... Background: Chromosome rearrangements are caused by many mutational mechanisms; of these, recurrent rearrangements can be particularly informative for teasing apart DNA sequence-specific factors. Some recurrent ...
8