Human eosinophils
Interactions between NADPH oxidase-related proton and electron currents in human eosinophils
... in human eosinophils was similar in unstimulated and PMA- activated ...in eosinophils before and after PMA activation provides further support for the idea that a single population of H + channels ...
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The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils
... in human eosi- ...of human eosinophils to a significant extent, it can be expected to be less potent in the treatment of asthma than the currently used ...
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Human eosinophils can express the cytokines tumor necrosis factor alpha and macrophage inflammatory protein 1 alpha
... that human eosinophils represent a potential source of TNF-alpha and MIP-1 alpha, that levels of expression of mRNA for both cytokines are high in the blood eosinophils ...
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Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid
... in continuous chart records of the holding current at _60 mV. The frequent interruptions are the result of depolarizing voltage pulses, which were applied to elicit H + currents that were recorded separately. In the cell ...
12
Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
... Release. Human eosinophils have the potential to re- lease ⬎24 cytokines including prototypical T helper (Th)1 ...of eosinophils through CD9 or LIR7 triggered release of IL-12 but not IL-4 ...of ...
7
Effective antigen presentation to helper T cells by human eosinophils
... blood eosinophils purified from non-allergic donors were pulsed with the antigens house dust mite extract (HDM), Timothy Grass extract (TG) or Mycobacterium tuberculosis purified protein derivative (PPD), before ...
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Human eosinophils express functional interleukin 2 receptors
... of eosinophils, we have investigated the capacity of human eosinophils to respond to ...with eosinophils from all normal and eosinophilic donors ...of eosinophils to ...on ...
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Platelet activating factor A potent chemotactic and chemokinetic factor for human eosinophils
... on human eosinophil locomotion (chemotaxis and chemokinesis). Human eosinophils (25-95% purity) were obtained from donors with a variety of diseases associated ...
7
Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
... In malignant cell lines activation of caspase cascades as well as changes in the expression of Bcl-2 family members have been described [9,10]. The exact mechan- isms how the survival-prolonging cytokines IL-5 and GM-CSF ...
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Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils
... Since its recent discovery, IL-17 has been described to be involved in various aspects of asthma pathogenesis. Elevated IL-17A levels were shown to correlate with in- creased airway hyper-responsiveness (AHR) in ...
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Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils
... density eosinophils obtained from patients with hypereosinophilic syndrome (HES) were stimulated with complement factor 5a (C5a), platelet-activating factor (PAF), FMLP and neutrophil-activating peptide ...
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Comparison of Human Eosinophils from Normals and Patients with Eosinophilia
... Previous studies of the biochemistry and physiology of eosinophils have relied upon cells obtained from patients with eosinophilia (EE). It is unknown whether such cells might have been activated or partially ...
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The pH dependence of NADPH oxidase in human eosinophils
... For excised-patch studies, eosinophils were activated with 60–200 nm PMA either before or after forming a seal to establish cell-attached patch configuration. The patch was then excised by lifting the pipette ...
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Temperature dependence of NADPH oxidase in human eosinophils
... 2001a). Eosinophils were isolated from the neutrophil preparation by negative selection using anti-CD16 immunomagnetic beads (Hansel et ...The eosinophils were suspended in Hepes (10 m M )-buffered HBSS ...
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Mechanisms of Killing of Newborn Larvae of Trichinella spiralis by Neutrophils and Eosinophils: KILLING BY GENERATORS OF HYDROGEN PEROXIDE IN VITRO
... of human eosinophils or neutrophils and generators of hydrogen peroxide (glucose-glucose oxidase) (G-GO) or superoxide and hydrogen peroxide (xanthine-xanthine ...
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Human eosinophil adhesion and degranulation stimulated with eotaxin and RANTES in vitro: Lack of interaction with nitric oxide
... murine eosinophils of IL-5 transgenic mice, eotaxin increases the CD11b and VLA-4 expressions, with maximal responses observed 1 h (CD11b) and 2 h (VLA-4) after incubation with eotaxin, suggesting that ...
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Eosinophils in glioblastoma biology
... in human eosinophils [112]. Of note, human astrocytes and GBM tumor cells are also known to produce GM-CSF [115-117], which may enhance oxidative stress in a microenvironment invol- ving ...vated ...
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Investigation of the machanism of exocytosis form the permeabilised guinea pig eosinophils
... pig eosinophils occurs in two ...[102]. Human eosinophils can degranulate in the presence of either Ca^"" or GTPyS but in the presence of both effectors, the increase in capacitance is much ...
160
Eosinophils in human oral squamous carcinoma; role of prostaglandin D2
... Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The ...
7
Behavior of eosinophil leukocytes in acute inflammation II Eosinophil dynamics during acute inflammation
... of eosinophils in the peripheral ...circulating eosinophils, a rapid accumulation of eosinophils at the periphery of the inflammatory site, and an inhibition of egress of eosinophils from the ...
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