human estrogen receptor α
Src promotes estrogen dependent estrogen receptor α proteolysis in human breast cancer
... Estrogen drives both transcriptional activation and proteolysis of estrogen receptor a (ERa; encoded by ESR1). Here we observed variable and overlapping ESR1 mRNA levels in 200 ERa-negative and 50 ...
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The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor α in human breast tumors in vivo
... that estrogen can regulate the mTOR ...by estrogen in a time dependent manner in MCF7 breast cancer cells and mTOR can be coimmunoprecipitated with ERα in these ...only estrogen re- sponsive and not ...
13
Estrogen promotes Leydig cell engulfment by macrophages in male infertility
... overexpresses human CYP19, which encodes aromatase (AROM+ mice), and mice with knockout of Esr1, encoding estrogen receptor α (ERαKO mice), to analyze interactions between viable Leydig cells ...
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The Transactivating Function 2 (AF 2) of Estrogen Receptor (ER) α Is Indispensable for ERα Mediated Physiological Responses and AF 1 Activity
... active or inactive form of the receptor. When agonists (transcription activating chemicals) bind to the LBD, helix 12 makes a co-activator binding surface and re- cruits transcriptional co-activators, such as ...
8
Metabolic properties of the osteoclast
... of human peripheral blood mononuclear cells [31, 32], whereas induction of HIF-1α increased their resorptive activity ...and estrogen receptor-α ...
21
Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
... both human and animal studies that estrogen is protective against vascular injury and ...of estrogen also have an important rapid compo- nent in the vasculature, which includes the acute activation ...
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Mechanisms for estrogen receptor expression in human cancer
... However, estrogen also promotes mammary, ovarian and endometrial tumorigen- ...esis. Estrogen antagonists and drugs that reduce estrogen biosynthesis have become highly successful therapeutic agents ...
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Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling
... in human cancer (through overexpression or genetic modification) indicates that NPM1 might play a role as both an oncogene and a tumor suppressor, depending on its dosage and level of expression ...
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Pharmacological Effects of Withanolides
... suppress estrogen receptor-α expression in human breast cancer cells [34], another report is by inhibiting the STAT3 signaling pathway [35]; Meanwhile, withaferin A promotes bone formation by ...
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Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation
... endometrial estrogen receptor α (ER α ), progester- one receptor A (PRA) and progesterone receptor B (PRB) protein levels ...normal human endometrial stromal and glandular ...
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Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... Furthermore, the transcription factor CCCTC- binding factor-like (CTCFL/BORIS) is a tran- scriptional regulator and paralogue gene of the CCCTC-binding factor (CTCF) transcriptional repressor, which is involved in gene ...
14
Membrane estrogen receptor α levels predict estrogen induced ERK1/2 activation in MCF 7 cells
... Phosphorylations leading to activation and subsequent inactivation of proteins are important regulatory mecha- nisms for control of cell growth and differentiation [64,65]. Although ERKs are thought to play a key role in ...
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The origins of estrogen receptor alpha positive and estrogen receptor alpha negative human breast cancer
... by estrogen-induced paracrine factors from adjacent ER-positive cells, which can become independent of this support, achieve a growth advantage, and progress to ER-negative breast ...primary human mammary ...
6
Triple-negative breast cancer: new perspectives for targeted therapies
... like, human epidermal growth factor receptor 2, and ...expressing estrogen receptors or progesterone receptors at all, and human epidermal growth factor receptor ...
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Quantitative hormone therapy follow-up in an ER+/ERαKD mouse tumor model using FDG and [11C]-methionine PET imaging
... of estrogen hor- mone therapy (pure antiestrogen, aromatase inhibitor, and selective estrogen receptor modulator (SERM)), it was deemed important to test the proposed ER+/ERαKD tumor-bearing mouse ...
10
Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
... follows: human c-FOS Fwd: 5’-CGAG CCCTTTGATGACTTCCT-3′ and ...GCTGTCTCAGA-3′; human EGR1 Fwd: 5’-GCCT GCGACATCTGTGGAA-3′ and ...ATCTTGGTATGC-3′; human CTGF Fwd: 5’-ACCT GTGGGATGGGCATCT-3′ and ...
16
Estrogen receptor–α in medial amygdala neurons regulates body weight
... neural populations that regulate body weight remain to be fully elucidated. Here we showed that single-minded–1 (SIM1) neurons in the medial amygdala (MeA) express abundant levels of ERα. Specific deletion of the gene ...
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Immunohistochemical profile and its association with clinicopathological parameters in carcinoma breast: a prospective study in central India
... complexity issues have to date rendered gene expression profiling impractical as a routine hospital diagnostic tool. However, there are immunohistochemistry surrogate panels proposed that can potentially identify these ...
7
Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer
... Since ER, PR, and HER2 are established molecular markers associated with response to targeted therapies, ER-/PR-/HER2-negative cancers are loosely grouped as TNBCs. Such cancers occur in 10 to 15% of patients, are ...
12
Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report
... Additionally, ILC is seen more often than IDC in cases of breast cancer that is metastatic to the abdominal organs, such as pancreas and gastrointestinal tract [14].The reasons for the different metastatic patterns ...
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