Human glioblastoma
Detection of circulating tumour cell clusters in human glioblastoma.
... Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear ...
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Neoplastic cells are a rare component in human glioblastoma microvasculature
... of human glioblastoma, one of the most aggressive forms of human ...stem-like glioblastoma cells have the capacity to differentiate into functional endothelial cells, and that a significant ...
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Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells
... in glioblastoma cells, T98G cell line derived from human glioblastoma was transfected with HA-tagged constructs expressing HMW-FGF2 (HA-HMW) or 18K-FGF2 ...
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Original Article LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway
... of human cancers have been elucidated, there is a pau- city of literature on the association between LRIG1 and the radiosensitivity of the tumor ce- lls, especially glioblastoma ...radioresistant ...
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Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma
... In human solid glioblastoma we have observed a coordinated overexpression of a panel of pro- inflammatory genes as compared to host normal ...in human glioblastoma acquisition of a ...
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The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells
... against human glioblastoma (GBM), which is a highly aggressive brain tumor that re- lies on angiogenesis for growth and histological progres- sion [20, ...
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The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
... The human glioblastoma cell lines T98G, DBTRG, and A172 were purchased from the ATCC and LN405 was obtained from the ...Primary glioblastoma cells P0297 and P0306 were established as described before ...
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Development and characterization of mouse models of human glioblastoma
... of human glioblastoma by targeting common mutations observed in human cases, including disruption of Rb pathway, activation of K-Ras and Pten ...to human GBM in regard to genetic changes and ...
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Celastrus orbiculatus extract inhibits the migration and invasion of human glioblastoma cells in vitro
... on human glio- blastoma U87 and U251 cell lines using various molecu- lar biology methods to explore the mechanisms by which COE acts against human ...
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Expression and prognostic significance of TCTN1 in human glioblastoma
... further indicated that Tctn1 modulated Hedgehog signal transduction downstream of Ptch, Smo and Rab23. How- ever, the findings were merely restricted in a mouse em- bryonic development context and lacked direct evidences ...
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Evolutionary dynamics of residual disease in human glioblastoma.
... Background: Glioblastoma is the most common and aggressive adult brain malignancy against which conventional surgery and chemoradiation provide limited ...tumour. Glioblastoma cells display a characteristic ...
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Modulation of miR-21 signaling by MPS1 in human glioblastoma
... in-house Glioblastoma Bio Discovery Portal (GBM- BioDP) [33] was used to measure differential expression from three platforms (Affymetrix HGU133A, Agilent G4502A, and HuEx-1_0-st-v2) within the subtypes of GBM (as ...
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Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate
... IMPORTANCE Glioblastoma (GBM), the deadliest type of brain tumor, is currently in- curable because of its high recurrence rate after traditional treatments, including surgery to remove the main part of the tumor ...
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Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis
... including glioblastoma, are re- sistant against many anti-cancer ...for glioblastoma is the use of alkylating agents, temozolomide, in combination with radiation ...
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Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
... Therefore, strategies inhibiting both mesenchymal proper- ties and MMPs may be an efficient way for cancer therapy. As shown in Figure 3, downregulation of mesenchymal markers/ activators such as N-cadherin, Snail, and ...
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Journal of Applied Pharmaceutical Science
... normal human cell (GM07492A), murine melanoma (B16F10), human cervical adenocarcinoma (HeLa), human hepatocellular liver carcinoma (HepG2), human breast adenocarcinoma (MCF-7), and ...
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Insulin receptor of human cerebral gliomas Structure and function
... from human brain tumors of glial origin was examined for the first time using intact cells (from an established cultured human glioblastoma cell line) and partially purified solubilized membranes ...
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Peripheral Immunization Blocks Lethal Actions of Vesicular Stomatitis Virus within the Brain
... Vesicular stomatitis virus (VSV) is the prototype virus for 75 or more negative-strand RNA viruses in the rhabdovirus family. Some of these viruses, including VSV, can cause neurological impairment or death upon brain ...
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RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model
... target human glioblastoma stem cells and their derived tumor cells through FA-FR specific ...from human patient derived stem cell-like glioblastoma cells, in which the aggressive ...
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5 Aminolevulinic Acid Squalene Nanoassemblies for Tumor Photodetection and Therapy: In Vitro Studies
... Protoporphyrin IX (PpIX) as natural photosensitizer derived from administration of 5-aminolevulinic acid (5-ALA) has found clinical use for photodiagnosis and photodynamic therapy of several cancers. However, broader use ...
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