Human Growth Hormone
Recombinant human growth hormone: a medical miracle or cause for concern?
... Human growth hormone (hGH) plays an important role in cell regeneration, growth and maintaining healthy human ...The hormone is naturally produced by somatropic cells in the ...
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Human growth hormone gene and the highly homologous growth hormone variant gene display different splicing patterns
... normal human growth hormone (hGH-N) and human growth hormone-variant (hGH-V) genes have been established in order to study the expression of these two highly homologous ...
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Metabolic effects of human growth hormone in corticosteroid treated children
... administered human growth hormone (HGH) were evaluated in dwarfed, prepubertal children who were receiving long-term corticosteroid therapy for a chronic ...of growth, whereas the ...
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Metabolic clearance rate of radioiodinated human growth hormone in man
... The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant ...
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Diurnal Variation in the Responsiveness of Human Subjects to Human Growth Hormone
... The objective of this study was to compare the responsiveness of human subjects to the anabolic effects of human growth hormone (HGH) administered at 8 a.m. or at 11 p.m. Three doses of HGH ...
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Metabolic clearance and production rates of human growth hormone
... of human growth hormone (HGH) was determined by the constant infusion to equilibrium technique utilizing HGH- 125 ...plasma growth hormone concentrations in normal subjects did not ...
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STUDIES ON THE EFFECTS OF HUMAN GROWTH HORMONE IN PREMATURE INFANTS
... The effects in the immature infant of the administration of a purified preparation of human growth hormone have been assessed in an attempt to elucidate the relationship of pituitary gro[r] ...
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Metabolic response to human growth hormone during prolonged starvation
... The metabolic response to human growth hormone (HGH) was studied in five obese subjects in the fed state and during prolonged (5-6 wk) starvation. In the fed state (three subjects), HGH induced an ...
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The effects of recombinant human growth hormone on skin, muscle and nerve
... adult growth hormone-deficient patients before and after six to twelve months of recombinant human growth hormone (r-hGH) treatment, as part o f a double-blind placebo controlled ...
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Comparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children
... anti-human growth hormone (-hGH) monoclonal antibody recognizing bind- ing site 2 of hGH was used to capture hGH from the serum ...the human GH receptor by ~ 20-fold, resulting in a ten- to ...
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Responsiveness of Growth Hormone Deficient Children to Human Growth Hormone EFFECT OF REPLACEMENT THERAPY FOR ONE YEAR
... exogenous human growth hormone (HGH) than non-GH-deficient ...linear growth was less than ...linear growth accelerated to 15-25 cm/yr for the first 4-7 mo, then declined to 0-8 ...
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Observations on the responsiveness of human subjects to human growth hormone: Effects of endogenous growth hormone deficiency and myotonic dystrophy
... of human growth hormone (HGH) on the N, P, Na, and K balance, and on the body weight (BW) of three groups of subjects was ...the hormone was administered for 7 ...
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Effects of recombinant human growth hormone administration on cardiovascular risk factors in obese children with relative growth hormone deficiency
... Collectively, all the above studies suggested that the re- duced GH secretion in obesity might cause cardiovascular consequences. Thus we assume that recombinant human growth hormone (rhGH) treatment ...
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A Microcalorimetry Study of the Binding of Nickel Ion by Human Growth Hormone
... recombinant human Growth Hormone (hGH), produced as an injected drug, has been done at 27˚C in NaCl solution (50 mM) using an isothermal titration ...
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STUDIES ON HUMAN GROWTH HORMONE II THE PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF HUMAN GROWTH HORMONE IN MAN
... This paper reports the plasma levels of growth ments of Salmon, Utiger, Parker and Reichlin 4, radioiodinated human growth hormone had hormone measured by a radio-immunoassay after a hal[r] ...
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Human Growth Hormone Treatment of Children with Growth Failure and Normal Growth Hormone Levels by Immunoassay: Lack of Correlation with Somatomedin Generation
... Growth Hormone Levels by Immunoassay: Lack of Correlation with Somatomedin Human Growth Hormone Treatment of Children with Growth Failure and Normal. http://pediatrics.aappublications.o[r] ...
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Dipeptidylpeptidase IV and trypsin like enzymatic degradation of human growth hormone releasing hormone in plasma
... competitive inhibitor. D-Amino acid substitution at either position 1 or 2 also prevented hydrolysis, characteristic of DPP IV. Analysis of endogenous plasma GRH immunoreactivity from a human GRH transgenic pig ...
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STUDIES ON HUMAN GROWTH HORMONE I A RADIO IMMUNOASSAY FOR HUMAN GROWTH HORMONE
... The sensitivity of the assay system is dependent not only on the specific activity of the labeled growth hormone, but also on the careful adjustment of the concentrations of rabbit anti-[r] ...
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Recombinant Human Growth Hormone Treatment for Dilated Cardiomyopathy in Children
... myocardial growth and function via GH receptor binding and JAK/STAT-mediated transcription of IGF-1, which in turn acts on cardiac myocytes through several different intracellular signaling pathways to alter Ca 2⫹ ...
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Considerations Related to the Use of Recombinant Human Growth Hormone in Children
... of human GH in a variety of disorders (Table 2) has been stimulated by both the success of human GH therapy in GH-deficient individuals of short stat- ure and the ready availability of synthetic GH prod- ...
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