human heme oxygenase 1
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase 1 deficiency
... Heme oxygenases (HO) are rate-limiting enzymes that cat- alyze the conversion of heme into carbon monoxide and biliverdin (1). They consist of two different isoforms, HO- 1 and HO-2. They have ...
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Heme oxygenase 1 deficiency accompanies neuropathogenesis of HIV associated neurocognitive disorders
... All human studies and protocols for monocyte isolation were reviewed and approved by the University of Pennsylva- nia IRB, and all participants provided written informed ...of human fetal astrocytes from ...
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Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy
... Administration of a specific HO inhibitor zinc protopor- phyrin resulted in remarkable increase of intracellular ROS, which subsequently induced the apoptosis to tumor cells [23,24]. Because of the potent antioxidative ...
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Heme oxygenase-1: emerging target of cancer therapy
... in human can- cers [68]. As HO-1 is one of the target genes regulated by Nrf2, it is apparent that HO-1-mediated antioxidant response contributes at least in part to the tumorigenic process promoted ...
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Therapeutic potential of statins and the induction of heme oxygenase-1 in preeclampsia
... the human placenta (Ahmed et ...in human chorionic villi in the first trimester of pregnancy were similar to those of term in the placenta of uncom- plicated pregnancy, whereas the expression of Hmox2 is ...
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Induction of Placental Heme Oxygenase-1 Is Protective Against TNFα-induced Cytotoxicity and Promotes Vessel Relaxation
... a human case of HO-1 deficiency, there is severe, persistent endothelial damage, as indicated by marked elevation in thrombomod- ulin and von Willerand factor ...
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Heme oxygenase-1 regulates mitochondrial quality control in the heart
... for 1 week (Figure 1A). To test the effect of HO-1 in this system, we compared the results of DOX administration in WT mice to those in mice that overexpress human HO-1 from a bacterial ...
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Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes
... To determine the effect of Hcy on HO-1 expression in HepG2 cells, qRT-PCR and Western blotting were perfor- med to detect the mRNA and protein levels of HO-1, respectively. As shown in Figure 3A, Hcy ...
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The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase 1
... and iron [25]. There are two functional isoenzymes of HO, HO-1 and HO-2 [26]. HO-1 represents a stress- responsive protein that is induced by exogenous and endogenous factors such as oxidative stress and ...
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The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication
... infections. Heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting step in heme degradation, has antioxidative properties and protects cells from various ...and ...
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Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase 1
... contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ ...Free heme is metabolized by heme ...
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ATF4 dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis
... HT1080 human fibro- sarcoma ...against human ATG5 (catalog L-004374), ATG7 (catalog L-020112), ULK1 (catalog L-005049), HO1 (catalog L-006372), and NRF2 (catalog L-003755) were obtained from Thermo ...
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DMO CAP inhibits influenza virus replication by activating heme oxygenase 1 mediated IFN response
... [10]. Heme oxygenase-1 (HO-1) is an inducible enzyme that degrades pro-oxidant heme into equimolar quantities of carbon monoxide (CO), iron, and biliverdin ...as human ...
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Pharmacological Inhibition of Host Heme Oxygenase 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes
... tuberculosis-infected human macrophages resulted in a reduction in intracellular bacterial loads as well as decreased proinflamma- tory cytokine production ...unclear. Heme triggers the production of ...
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Regulatory role of heme oxygenase-1 in silica-induced lung injury
... The mice were anesthetized with ketamine (80 mg/kg; Sigma-Aldrich, St. Louis, MO, USA) or sodium thiopental (50 mg/kg Nembutal; Dainippon-Sumitomo Seiyaku. Co., Ltd., Osaka, Japan) and xylazine (10 mg/kg; Sigma). A ...
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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death
... The heme oxygenase (HO) is a major intracellular source of ...of heme oxygenase in Erastin-triggered ferroptotic cancer cell death has been ...
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Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats
... of heme arginate, a potent inducer of heme oxygenase (EC ...of heme arginate (15 mg/kg body weight for 4 d) resulted in a marked decrease in blood pressure from ...by heme arginate. ...
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Disrupted postnatal lung development in heme oxygenase-1 deficient mice
... no difference of survival rate in the treated and control HO-1 mutants. Consistent with our data at earlier time point P10, HO-1 mutant lungs at P14 displayed defective alveolar structure at baseline, ...
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Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
... of heme proteins by inducing the heme- degradative enzyme, heme oxygenase, as well as increasing the synthesis of ferritin, the major cellular repository for ...
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Relationship of Heme Oxygenase-1 (HO-1) Level with Onset and Severity in Normotensive Pregnancy and Severe Preeclampsia
... conducted on the levels of HO in the placenta, and only few data are available regarding the changes in maternal serum HO-1 level in normal pregnancies and pregnancies complicated by preeclampsia. Our results show ...
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