human HMG-CoA reductase
Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
... atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human ...
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HMG-CoA reductase inhibitor lovastatin upregulates plasminogen activator production through RhoA-signaling in peritoneal cell line Met5A
... (HMG-CoA) reductase inhibitor statin, known to protect postoperative adhesion in animal model, affect the expressing tissue-type plasminogen activator (tPA) in peritoneal cells in ...culture. ...
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Aplexone targets the HMG CoA reductase pathway and differentially regulates arteriovenous angiogenesis
... in human endothelial cells, indicating that aplexone inhibits endothelial cell migration by interfering with the geranylgeranylation branch of the HMGCR ...cultured human endothelial cells suggests that ...
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7 Dehydrocholesterol–dependent proteolysis of HMG CoA reductase suppresses sterol biosynthesis in a mouse model of Smith Lemli Opitz/RSH syndrome
... the human fetus, in agreement with numerous obser- vations that maternal cholesterol is obligate for murine (41–43) but not for human (44) development and that considerable amounts of maternal choles- terol ...
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Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer
... The evaluation of statins to potentiate other established antineoplastic therapeutic modalities, such as radiotherapy, may yield more implications for clinical management. In prostate cancer, several laboratory studies ...
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Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
... specifically HMG-CoA reductase inhibitors, has been reported to have immunosuppressive effects in a study of heart transplant recipients ...in human endothelial ...of HMG-CoA ...
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3-HMG-CoA Reductase Inhibitors and Inflammation: Underlying Mechanisms and Role in Atherosclerosis
... demonstrates that statin treatment reduces the macrophage infiltrate and the expression of MMP-1, MMP-3, MMP-9 and tissue factor in the same model and decreases macrophage proliferation and proteolytic activity due to ...
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Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells
... inhibit HMG-CoA reductase activity in other non-hepatic human cells is considered to vary with their lipophilicity, simvastatin being 5- to 40-fold more potent than ator- vastatin and ...
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Journal of Applied Pharmaceutical Science
... control human clinical trial involving 38 current ...on HMG-CoA Reductase and ACAT hepatic/intestine enzymes to elucidate its possible ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Studies in normal subjects
... Finally, reductase activity was inhibited by dichloroacetate, a compound known to lower plasma cholesterol in man and inhibit the human leukocyte enzyme in ...controlling HMG CoA ...
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Biologically active low density lipoprotein in human peripheral lymph
... of human serum and peripheral lymph to suppress the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), to activate cholesteryl ester synthesis, and to ...
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56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... A reductase, the enzyme that synthesizes mevalonate, appears to be regulated through a multivalent feedback ...the reductase requires the presence of at least two regulators: cholesterol, which is n ormally ...
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Statins and Sepsis: Possible Connections and Therapeutic Implications
... 3-HMG-CoA reductase inhibitors (statins) exhibit pleiotropic effects independent of lipid lowering, encompassing antiinflammatory, immunomodulatory, antiapoptic and antithrombotic ...
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Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin
... Statin medications are first-line pharmacotherapy for the treatment of hypercholesterolemia and prevention of cardiovascular disease, and an estimated 25.2 million Americans are currently receiving statin therapy ...
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The mechanism of dietary cholesterol effects on lipids metabolism in rats
... As we know, VLDL is assembled in liver and secreted to serum, and high hepatic TG level induces high serum TG concentration. That is because VLDL is mainly composed of TG. But our previous research found that cholesterol ...
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The Influence of Sam Chil Geun (Panax Notoginseng) on the Serum Lipid Levels and Inflammations of Rats with Hyperlipidemia Induced by Poloxamer 407
... Lovastatin and pravastatin inhibited cholesterol synthesis by acting as HMG-CoA reductase inhibitors.25 In the present study, the Sam-Chil-Geun extract was administered to the rats with [r] ...
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Adenovirus mediated transfer of a gene encoding cholesterol 7 alpha hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol
... Clinical interventions that accelerate conversion of cholesterol to bile acids reduce circulating low density lipoprotein (LDL) cholesterol concentrations. The initial and rate- limiting step in the bile acid ...
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CHRONOPHARMACOTHERAPEUTIC RELEASE OF HMG COA REDUCTASE INHIBITOR: USING NOVEL COATING TECHNIQUE
... words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. [2] There are many conditions that demand ...
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Unexpected inhibition of cholesterol 7 alpha hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits
... hydroxylase and hepatic LDL receptor function and mRNA levels in 23 New Zealand White (NZW) and 17 Watanabe heritable hyperlipidemic (WHHL) rabbits. Plasma cholesterol concentrations were 9.9 times greater in WHHL than ...
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Insilico predictions of inhibitors of novel statin structural analogues with HMG CoA reductase
... Computer aided drug design is no longer merely a promising techniques. It is a practical and realistic way of helping the medicinal chemistry. Still drugs must be synthesized and tested by the computational techniques ...
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