Human IgE
Human IgE mAbs define variability in commercial Aspergillus extract allergen composition
... the IgE molecule (1). In sensi- tized (IgE antibody–positive) individuals, reexposure to an allergen leads to IgE engagement by the aller- gen, resulting in FcεRI cross-linking and activation of mast ...
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The immunoglobulin like modules Cε3 and α2 are the minimal units necessary for human IgE FcεRI interaction
... of human IgE antibodies and FcεRI (6). IgE, the least abun- dant immunoglobulin class, contains 4 heavy-chain con- stant immunoglobulin domains ...on human IgE may be due to the lack of ...
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Biosensor for human IgE detection using shear mode FBAR devices
... Film bulk acoustic resonators (FBARs) have been evaluated for use as biosensors because of their high sensitivity and small size. This study fabricated a novel human IgE biosensor using shear-mode FBAR ...
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Obtaining and study of properties of new monoclonal antibodies against human IgE
... Серед 24 гібридом, відібраних під час пов торного скринінгу, для подальшої характе- ристики залишили лише 19 клонів гібридом, які характеризувалися відносно високими сигналами на ІgЕ людини і Fc-фрагменти IgE і не ...
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The effect of intravenous administration of a chimeric anti IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics
... anti–human IgE antibody that binds to free IgE and surface IgE of IgE-expressing B cells but not to IgE bound to high affinity IgE receptors (Fc e R1) on mast cells and ...
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Potentiation of human immunoglobulin E synthesis by plasma immunoglobulin E binding factors from patients with the hyperimmunoglobulin E syndrome
... Affinity-purified IgE-binding factors from the plasma of patients with the hyper IgE syndrome (HIE) were assessed for their capacity to enhance IgE synthesis by B cells derived from patients with ...
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Serum IgE clearance is facilitated by human FcεRI internalization
... of IgE, while basophils retained approximately 100% (Figure ...monitored IgE on the surface of cDCs in the ...surface IgE at 24 hours after injection (Figure ...of IgE but lost most of it as ...
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An investigation into IgE facilitated allergen recognition and presentation by human dendritic cells
... the IgE 2C7 anti- body was used with either Der p 1 or deglycosylated Der p 1, in comparison with using Der p 1 or deglycosylated Der p 1 alone (Figure ...of IgE 2C7 than gly- cosylated Der p ...by ...
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Metabolism of immunoglobulin E in patients with markedly elevated serum immunoglobulin E levels
... of human IgE was studied in normals, severe atopics, and patients with the hyperimmunoglobulin E-recurrent infection (HIE; Job's) syndrome to determine whether IgE metabolism is altered in patients ...
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Antibodies specific for a segment of human membrane IgE deplete IgE producing B cells in humanized mice
... serum IgE with IgE-specific antibodies is in general an efficacious treatment for allergic asth- ma, one limitation of this approach is its lack of effect on IgE ...disrupt IgE production by ...
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FcγRIV is a mouse IgE receptor that resembles macrophage FcεRI in humans and promotes IgE induced lung inflammation
... of human FcγRIIIA (hFcγRIIIA) because of high sequence ...low-affinity IgE receptor for all IgE ...by IgE immune complexes. Engagement of mFcγRIV by IgE immune complexes induced ...
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Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera
... pre-existing IgE and IgE development during treatment by a newly established IgE cross-reactivity immune profiling (ICRIP) assay ...with IgE binding to the immunogenic/allergenic therapeutic ...
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The high affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes
... of IgE-bearing macrophages (43) and DC (44, ...FcεRI-bound IgE with environmental allergens ...ic IgE or anti-FcεRI mAb F(ab) to FcεRI has been shown to enhance the expression of adhesion molecules ...
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Prenatal allergic sensitization to helminth antigens in offspring of parasite infected mothers
... total IgE levels were observed in 82% of 57 cord sera tested (geometric mean ...contained IgE antibodies specific for filarial antigens as determined by solid-phase ...filaria-specific IgE to total ...
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Sensitization to timothy grass pollen allergenic molecules in children
... an IgE-based ...were IgE reactive on ISAC to at least one of the timothy grass pollen allergens as representative markers of other hom- ologous grass ...allergen IgE-reactive subjects (p < 0.001), ...
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Known allergen structures predict Schistosoma mansoni IgE-binding antigens in human infection
... parasite IgE-binding proteins in chronic infec- tions, IgG4 is thought to be induced as part of a protective anti-inflammatory regulatory response to IgE-mediated inflam- mation (reviewed (45) and (23), ...
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Glucocorticoids upregulate CD40 ligand expression and induce CD40L dependent immunoglobulin isotype switching
... HC was found to upregulate CD40L mRNA expres- sion (Figure 2a). This effect was GC specific because it was observed with DM, but not with progesterone. Fur- thermore, it was likely due to enhanced CD40L gene ...
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On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria
... autoreactive IgE were similar in all CSU patients and independent from their total IgE ...drug-reactive IgE from total IgE levels ...autoreactive IgE in CSU. First, IgE ...
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Diagnosing and managing food allergy in children
... Of the children presenting with suspected allergy, there are symptoms reported that are not due to a food or other precipitant. This is a challenging group. In some, another diagnosis may be made but this is not always ...
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IgE serum concentration against airborne fungi in children with respiratory allergies
... However, this study has some limitations. First, we have not accounted or discounted the possibility that the findings could be a result of indoor exposures on elevated IgE. In addition, the sample included only ...
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