Human Immunodeficiency Virus and CD4
Role of CD4 endocytosis in human immunodeficiency virus infection.
... of CD4 endocytosis in human immunodeficiency virus (HIV) entry by measuring the infection of HeLa cells expressing various CD4 constructs with endocytosis rates of between ...limited ...
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Increased Neutralization Sensitivity of CD4-Independent Human Immunodeficiency Virus Variants
... occurring human immunodeficiency virus (HIV-1) variants require the presence of CD4 and specific chemokine receptors to enter a ...bypassing CD4 and utilizing only the CCR5 chemokine ...
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Sphingomyelinase Restricts the Lateral Diffusion of CD4 and Inhibits Human Immunodeficiency Virus Fusion
... inhibits human immunodeficiency virus type 1 (HIV-1) ...of CD4 decreased 4-fold following sphingomyelinase treatment, while the effective diffusion rate of CCR5 remained ...proteins ...
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Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4.
... during human immunodeficiency virus type 1 (HIV-1) infection is established by downmodulation of the principal virus receptor, ...a virus carrying the chloramphenicol acetyltransferase ...
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Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein.
... receptor, CD4, have been proposed in facilitating human immunodeficiency virus type 1 (HIV-1) entry, including virion binding to the target cell and the induction of conformational changes in ...
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Macrophage-tropic strains of human immunodeficiency virus type 1 utilize the CD4 receptor.
... To characterize the role of CD4 in human immunodeficiency virus type 1 (HIV-1) infection of macrophages, we examined the expression of CD4 by primary human monocyte-derived macrophages a[r] ...
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An Alteration of Human Immunodeficiency Virus gp41 Leads to Reduced CCR5 Dependence and CD4 Independence
... 2008 Human immunodeficiency virus (HIV) type 1 infection requires functional interactions of the viral surface (gp120) glycoprotein with cell surface CD4 and a chemokine coreceptor (usually ...
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Human Immunodeficiency Virus Integration Efficiency and Site Selection in Quiescent CD4+ T Cells
... quiescent CD4 ⴙ T cells were thought to be resistant to human immunodeficiency virus (HIV) ...quiescent CD4 ⴙ T cells occurs in sites similar to those of their prestimulated ...
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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef ...of CD4, while most of the p56 lck was upheld at the cell ...Nef, CD4 accumulated in acidic ...
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CD4-Independent Infection of Astrocytes by Human Immunodeficiency Virus Type 1: Requirement for the Human Mannose Receptor
... Human immunodeficiency virus type 1 (HIV-1) infection occurs in the central nervous system and causes a variety of neurobehavioral and neuropathological ...utilize CD4 and chemokine ...
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Human Immunodeficiency Virus Env-Independent Infection of Human CD4− Cells
... target CD4 ⫺ cells, thus facilitating entry of the virus into the target ...to CD4 molecules but may still infect cells via the route described ...tested CD4 ⫺ cells with equal ...these ...
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Characterization of in vitro inhibition of human immunodeficiency virus by purified recombinant CD4.
... We took the approach of attempting to dissect activity measurement, p24 antigen content measurement cess of infection by using temperature; H9 cells were (Abbott Laboratories), and Weste[r] ...
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Insertion of the human immunodeficiency virus CD4 receptor into the envelope of vesicular stomatitis virus particles.
... chimeric CD4/G protein, the other coinfection was carried out with a vaccinia virus recombinant expressing an unre- lated cytoplasmic protein. Differences in virus titers were clearly ob[r] ...
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CD4-independent infection of human neural cells by human immunodeficiency virus type 1.
... The results indicate that CD4 is not the receptor for HIV-1 infection of the glioblastoma line U373-MG, medulloblastoma line MED 217, or primary human fetal neural cells.. In addition to[r] ...
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Depletion of the surface CD4 molecule by the envelope protein of human immunodeficiency virus expressed in a human CD4+ monocytoid cell line.
... To determine why CD4 molecules diminished from the cell surface after the induction of gpl60 protein production, the possible relation of CD4 and gpl60 protein in the cytoplasm was evalu[r] ...
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Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 binding.
... We expressed two forms of HIV type 1 (HIV-1) gpl20 in SF9 cells containing or lacking the natural signal sequences which control intracellular localization and glycosylation and found th[r] ...
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CD4-Chemokine Receptor Hybrids in Human Immunodeficiency Virus Type 1 Infection
... between CD4 and CXCR4 could be expressed efficiently on the cell surface and that both the CD4 and chemokine receptor components of these hybrid mole- cules adopted conformations similar to those of their ...
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Oral Candidiasis in Human Immunodeficiency Virus Patients and Its Correlation with CD4 Count
... bearing CD4 marker at their ...of human immune cells bearing CD4 antigen receptor, the most important being T helper cells (CD4 T cells), B lymphocytes, mac- rophage, and natural killer cells, ...
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Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells.
... Light (a and c) or fluorescence micrographs (b and d) of syncytia formed during a 2-h coculture of CD4-bearing human A2.01 cells, coinfected with vTF7-3 and vEB-8, and gpl6O-expressing, [r] ...
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Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells.
... However, in contrast to CD4-positive HeLa cells, CD4-positive U87MG and SCL1 cells were unable to form syncytia when cultured with cells expressing HIV envelope protein.. Thus, the inabi[r] ...
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