human natural killer-1
Human Uterine Natural Killer Cells but Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection by Secretion of CXCL12
... and 1 mM sodium pyruvate [Mediatech, Manassas, VA], ...5% human se- rum), for 2 to 3 days to allow for the recovery of cells following ...a human NK cell enrichment cocktail containing a combination ...
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Alloreactivity and Association of Human Natural Killer Cells with the Major Histocompatibility Complex
... conferred by HLA-Cw*1401 and the HLA-Cw allele carried on the 44.2 AH support the involvement of additional genes. Indeed, cellular responses are often controlled by the opposing actions of tyrosine kinases activating ...
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) p12I Down-Modulates ICAM-1 and -2 and Reduces Adherence of Natural Killer Cells, Thereby Protecting HTLV-1-Infected Primary CD4+ T Cells from Autologous Natural Killer Cell-Mediated Cytotoxicity despite the Reduction of Major Histocompatibility Complex Class I Molecules on Infected Cells
... Apart from the inhibitory control via the coengagement of iNKRs with MHC-I on target cells, NK cell cytotoxicity also involves adhesion, synapse formation, polarization, and de- granulation. These processes involve the ...
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Antibody dependent CD56+ T cell responses are functionally impaired in long term HIV 1 infection
... CD56+ T cells, also termed CD3+ CD56+ NKT-like cells, comprise approximately 5–15% of peripheral circu- lating T cells in human and express cell-surface molecule- CD56, a typical marker for natural ...
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Intracellular Disposition of Fludarabine Triphosphate in Human Natural Killer Cells
... (NBMPR)-sensitive human equilibrative nucleoside transporter 1 (hENT1), the NBMPR-insensitive human equilibrative nucleoside transporter 2 (hENT2), and the human concentrative nucleoside ...
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In vitro infection of natural killer cells with different human immunodeficiency virus type 1 isolates.
... Viral replication was demonstrated by detection of p24 antigen intracellularly and in culture supernatants, by the presence of HIV DNA within infected cells, and by the ability of supern[r] ...
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Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction
... factor 1 (46) and (ii) this factor has been shown to be necessary and sufficient for inducing IL-15 (52), it would not be surprising if the ultimate effector molecule of these IFN-mediated effects was found to be ...
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A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans
... by human natural killer T (NKT) cells, this long form resulted in greater NKT cell cytolytic activity against HAV-infected liver cells, compared with the shorter TIM-1 protein without the ...
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Biology of interleukin-6 production by human natural killer cells
... Natural Killer (NK) cells are an important element of innate immunity and have both regulatory and effector functions. Previous studies have demonstrated that NK cells are not a homogenous group of innate ...
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Conferral of Enhanced Natural Killer Cell Function by KIR3DS1 in Early Human Immunodeficiency Virus Type 1 Infection
... In an analysis of limited statistical power (n ⫽ 3 versus n ⫽ 18), we observed some evidence that those carrying B*58 su- pertype (a B*57 or B*58 allele) and KIR3DS1 had higher NK cell functional activity in both the ...
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Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin
... Influenza virus HA inhibits primary NK cell cytotoxicity. The effect of HA protein on NK cell activity was examined next. After incubation with HA at the indicated concentration for 24 h, NK cells were collected and ...
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Acute Clearance of Human Metapneumovirus Occurs Independently of Natural Killer Cells
... of natural killer (NK) cells for immunity against large DNA viruses is established (3–7); however, whether NK cells contribute to RNA virus immunity is ...
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Contributions of natural killer cells to the immune response against Plasmodium
... of human malaria disease states; however, depending on the strain of parasite and the genetic background of the mouse strain used, a wide range of outcomes can be mechanistically investigated, from parasitaemia to ...
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The role of nonspecific cytotoxic cells and cytokine production in the pathogenesis of human intestinal diseases
... General Introduction 1.1 Characteristics of natural killer and killer cells 1 1.2 Killer cells and antibody-dependent cellular cytotoxicity 6 1.3 The origin and differentiation of natura[r] ...
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Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus Induced Autoimmunity
... ABSTRACT The initiating events in autoimmune disease remain to be completely understood, but it is thought that genetic pre- disposition synergizes with “environmental” factors, including viral infection, leading to ...
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Natural Killer Cell Immunodeficiency in Siblings: Defective Killing in the Absence of Natural Killer Cytotoxic Factor Activity in Natural Killer and Lymphokine-Activated Killer Cytotoxicities
... Natural killer cells play important roles in the defense against tumor growth and viral infections.’ In the cytolytic event, natural killer cells first nec- ognize and bind to a target c[r] ...
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Novel Role for Interleukin-2 Receptor-Jak Signaling in Retrovirus Transmission
... Since free HTLV virions are essentially noninfectious and virus transmission can occur through cell-cell contact and fu- sion (21, 30, 46), we addressed the ability of IL-2 and p12 to regulate membrane fusion induced by ...
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Exogenous Activation of Invariant Natural Killer T Cells by α Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza
... . Combination treatment (at 14 dpi) re- sulted in a less intense IAV-pneumococcus-induced inflamma- tory response and a lower morbidity rate in the superinfected hosts. However, for reasons that have yet to be ...
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IL-15 as a potential target in leukemia
... tion of peripheral mononuclear cells of infected patients. In these patients, an elevation of IL-15 mRNA was also detected. This phenomenon was also confirmed in another study, where an increase of IL-15R α , IL-15 mRNA ...
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Adult cancer related hemophagocytic lymphohistiocytosis – a challenging diagnosis: a case report
... cytotoxic NK cells, and decreased NKG2A in cytokine- producing NK cells in our case. The expression of CD69 and NKG2A in NK cells was evaluated in four other nor- mal donors and the results were similar to the one ac- ...
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