Human natural killer (NK) cells
Membrane markers, target cell specificity, and sensitivity to biological response modifiers distinguish human natural cytotoxic from human natural killer cells
... In the present report, we provide evidence for the distinct existence of a human natural cytotoxic (HNC) cell. This HNC cell can be identified by the monoclonal antibody HNC-1A3 and by the absence of the ...
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Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection
... A genomic DNA mini-spin kit was purchased from QIAGEN (Cat. No. 12143). Reverse sequence-specific oligonucleotide probes (R-SSO) and genotyping reagents were provided by One Lambda Inc. (R-SSO-008N, CA, USA). ...
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Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection Enhances the Antiviral Response Mediated by NK Cells
... (NKT) cells being among the main mediators of early host ...of NK cells in these processes has been the subject of intensive investigation, and it is clear that they play a crucial role as effectors ...
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Aspergillus fumigatus responds to natural killer (NK) cells with upregulation of stress related genes and inhibits the immunoregulatory function of NK cells
... in NK cell mediated killing of fungi [5, 9, 13], increase in IL-2 prestimulated NK cells in the absence of ...fumigatus, NK cells rapidly upregulate the translation of preexisting mRNA ...
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IMPORTANT HUMAN GENES: THEIR LENGTH, LOCATION, PRODUCT, IMPORTANCE IN PROPER BODY FUNCTIONING AND INVOLVEMENT IN GENETIC DISORDERS
... T cells to prevent the action of natural killer (NK) cells during body immune response to viral infections 45-47 ...B cells survival chances, its proliferation, and ability to ...
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Natural killer cells and natural killer T cells in Lyme arthritis
... with NK cells, patients with antibiotic-responsive arthritis had higher frequencies of iNKT cells in SF than PB, but these cells were often absent in SF in patients with antibiotic-refractory ...
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Natural killer cells in human autoimmune disorders
... However, NK cell defects have been identifi ed in treatment-naïve patients before overt progression to disease or at the time of diagnosis, demonstrating that the defects are not solely treatment related or the ...
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The modulation of immunological activities in human NK cells by extracts of ginkgo
... Natural killer (NK) cells are non-T, non-B lymphocytes that play critical roles in defense against virally infected cells and in tumor surveillance [7, ...These cells are ...
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Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts
... transplantation; NK: Natural killer; KIR: Killer immunoglobulin-like receptors; HLA: Human leukocyte antigens; GvT: Graft versus tumor; GvH: Graft versus host; MICA/B: Major ...
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Emerging role of Natural killer cells in oncolytic virotherapy
... defense, NK cells play a dual role in OVT, driving both antitumor and anti-OV ...of NK cells so as to improve the outcome of ...of NK cells in OVT seems to be both tumor- and ...
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Atorvastatin prevents age related and amyloid beta induced microglial activation by blocking interferon gamma release from natural killer cells in the brain
... resident cells in the brain are capable of producing IFNg and whether endogenous IFNg stimulates microglial activa- ...brain cells produce IFNg only in very specific ...in human tumour neuroglia and ...
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Comparison of autogeneic and allogeneic natural killer cells immunotherapy on the clinical outcome of recurrent breast cancer
... the human peripheral blood lymphocyte separation liquid (Haoyang Biological Manufacture ...Isolated cells were enriched via binding to magnetic CD326 (EpCAM) MicroBeads (Miltenyi Biotech ...isolated ...
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Original Article CD38 positive natural killer cells may be involved in progression of inflammation in rheumatoid arthritis patients
... SF NK cells. In addition, NK cells in the PB and SF were not associated with the enhanced cytotoxicity in response to CD38 ligation or IL-2 alone, and CD38-mediated lytic function could be ...
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The early intestinal immune response in experimental neonatal ovine cryptosporidiosis is characterized by an increased frequency of perforin expressing NCR1+ NK cells and by NCR1− CD8+ cell recruitment
... cNK cells and T lymphocytes are known to be significant producers of IFNγ and it will be of interest to ascertain in future studies their relative contributions to its production during the course of ...NK22/ILC22 ...
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Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection
... acute NK cell response to GBV-B infection was characterized by increased cytotoxic arming, IFN-␥ production, cell proliferation, tissue homing, and accumulation in the ...enhanced NK cell function during ...
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Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System
... immunity, natural killer cells and alveolar macro- phages, to modulate immune responses to infection and dictate the severity of secondary ...inflammatory cells, including NK ...
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Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect
... Increasing evidence indicates the promising outcome of FMT as an encouraging treatment option for Crohn’s dis- ease (CD). However, the frequency of FMT for CD treat- ment remains unclear. In the first study that ...
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γδ T cells and NK cells – Distinct Pathogenic Roles as Innate Like Immune Cells in CNS Autoimmunity
... Th17 cells produce an array of other inflammatory cytokines, including IL-17F, GM-CSF, IL-22, IL-21, IL-26 and TNF-α (16, ...Th17 cells have been implicated in the pathogenesis of most common autoimmune ...
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Coxsackievirus B3 Proteins Directionally Complement Each Other To Downregulate Surface Major Histocompatibility Complex Class I
... I heterodimers was less pronounced, the relative activities of the three CVB3 proteins were the same as those depicted in Fig. 4C, and the differences were statistically highly significant. CVB3 2B and 2BC induce a ...
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Preconditioning is an effective strategy for improving the efficiency of mesenchymal stem cells in kidney transplantation
... or 7 days before transplantation effectively decreased the percentage of T, B, and NK cells in peripheral blood, boosted the induction of Tregs, and prolonged graft sur- vival. Furthermore, rats in the day ...
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