Human Neutrophil Elastase
Molecular docking analysis of natural compounds as Human neutrophil elastase (HNE) inhibitors
... of human neutrophil elastase (HNE) has been the main focus of investigation, due to its potential therapeutic application in medicinal ...of human neutrophil elastase (HNE) with ...
5
Development of an assay for in vivo human neutrophil elastase activity Increased elastase activity in patients with alpha 1 proteinase inhibitor deficiency
... to human neutrophil elastase (HNE) by the following criteria: activity was completely blocked by a specific HNE inhibitor or by adsorbing HNE from the extracts with a monospecific antibody and ...
9
<p>Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies</p>
... Human neutrophil elastase (HNE) is a serine protease that cleaves the extracellular matrix protein elastin. There is evidence that it also up-regulates a number of pro- in fl ammatory cytokines, as ...
11
Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors
... Human neutrophil elastase (HNE) is a small, soluble gly- coprotein of about 30 kDa belonging to the chymotrypsin family of serine proteases [1] and is expressed primarily in neutrophils, but also in ...
15
Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
... Optimal defence against the diverse types of microorganisams that invade our body requires specialised classes of non-specific and antigen-specific immune responses. The innate immune system includes phagocytic cells, ...
283
Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins
... coagulation human polymorphonuclear leukocytes release elastase in amounts that can exceed 100 ...of elastase on platelet structure and ...of elastase specifically inhibited thrombin-induced ...
11
Neutrophil mediated injury to endothelial cells Enhancement by endotoxin and essential role of neutrophil elastase
... purified human neutrophil elastase, and different from that induced by hydrogen peroxide ...Further, neutrophil-mediated injury was not inhibited by scavengers of a variety of oxygen radical ...
12
Neutrophil accumulation in the lung in alpha 1 antitrypsin deficiency Spontaneous release of leukotriene B4 by alveolar macrophages
... with human neutrophil elastase resulted in the release of the same neutrophil chemotactic ...purified human alpha 1AT was able to prevent the neutrophil elastase from ...
8
Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture
... Effect of varying cell number on gel contraction and collagen degradation. Collagen gels were prepared with co cultures containing varying concentrations of either monocytes or fibroblasts. The gels were then floated in ...
7
Effect of needle puncture and electro acupuncture on mucociliary clearance in anesthetized quails
... (an elastase inhibitor), Maimendongtang (a classic Chinese herbal prescription), Radix Ophiopogonis (RO, the major herb of Maimendongtang) and ophiopogonin-D (an active com- ponent of RO) significantly inhibited ...
6
Chemotactic responses of fibroblasts to tropoelastin and elastin derived peptides
... either human aortic elastin with human neutrophil elastase or from bovine ligament elastin with pancreatic elastase, elicited chemotactic responses that were maximal at ...
6
Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate
... key neutrophil functions, including the capacity to undergo sponta- neous programmed cell death and to induce an oxida- tive burst in response to formylated ...
9
A critical role for neutrophil elastase in experimental bullous pemphigoid
... and neutrophil infiltration of the upper dermis ...of neutrophil recruit- ment into skin sites resulted in the neutralization of the pathogenic activity of anti-murine BP180 (anti- mBP180) antibodies in ...
12
The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease
... CAP37, neutrophil elas- tase, and cathepsin G to RAGE was observed, but whether these neutrophil proteins act as agonists or antagonists of RAGE remains ...
15
Host Antimicrobial Peptides: the promise of new treatment strategies against Tuberculosis
... addition, human RNase7, also called the skin derived RNase, is also secreted by keratinocytes and exerts a protective role against a variety of pathogens at the skin bar- rier (39, ...that human RNases 3, ...
18
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses
... After obtaining the BAL fluid, lungs were fixed in 10% formalin. Blocks of lung tissue were cut around the main bronchus and embedded in paraffin blocks. Tis- sue sections 4 μm thick were affixed to microscope slides and ...
13
Susceptibility of lung epithelium to neutrophil elastase: protection by native inhibitors
... Historically neutrophil elastase (NE) has been regarded as the primary mediator of tissue damage which occurs during pulmonary em- physema, notably by degradation of extracellu- lar ...
11
Anti neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor
... Secretory leukoprotease inhibitor (SLPI), a 12-kD nonglycosylated serine antiprotease with a high capacity for inhibiting neutrophil elastase (NE), is produced by cells of mucosal surfaces including the ...
8
Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: Implications for treatment
... that elastase could induce cathepsin G and MMP-2 expression and activity in ...that elastase presides over a novel hierarchy in protease regulation, causing tissue destruction in diseases asso- ciated with ...
9
Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha 2 macroglobulin
... the elastase and antielastase activity of the alveolar fluid of seven patients with the adult respiratory distress syndrome (ARDS) and thirteen normal ...antineutrophil elastase activity was also ...
9