Human neutrophil elastase (HNE)
Molecular docking analysis of natural compounds as Human neutrophil elastase (HNE) inhibitors
... of human neutrophil elastase (HNE) has been the main focus of investigation, due to its potential therapeutic application in medicinal ...of human neutrophil elastase ...
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<p>Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies</p>
... Human neutrophil elastase (HNE) is a serine protease that cleaves the extracellular matrix protein ...as HNE-de fi cient mice have been shown to be protected against dextran sodium ...
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Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors
... Abstract: Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory ...inhibit ...
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Development of an assay for in vivo human neutrophil elastase activity Increased elastase activity in patients with alpha 1 proteinase inhibitor deficiency
... to human neutrophil elastase (HNE) by the following criteria: activity was completely blocked by a specific HNE inhibitor or by adsorbing HNE from the extracts with a ...
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Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
... Optimal defence against the diverse types of microorganisams that invade our body requires specialised classes of non-specific and antigen-specific immune responses. The innate immune system includes phagocytic cells, ...
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Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins
... coagulation human polymorphonuclear leukocytes release elastase in amounts that can exceed 100 ...of elastase on platelet structure and ...of elastase specifically inhibited thrombin-induced ...
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Effect of needle puncture and electro acupuncture on mucociliary clearance in anesthetized quails
... Since the needling manipulation of acupuncture is a spe- cial technique, only well-trained clinicians are authorized as acupuncture practitioners or acupuncturists. The stimu- lation by different acupuncturists may vary ...
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Nanocellulose Based Biosensors: Design, Preparation, and Activity of Peptide Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity
... of neutrophil serine pro- teases that distinguish human neutrophil elastase, pro- teinase 3, and chathepsin G activities at free and mem- brane bound subnanomolar concentrations of HNE ...
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Neutrophil accumulation in the lung in alpha 1 antitrypsin deficiency Spontaneous release of leukotriene B4 by alveolar macrophages
... with human neutrophil elastase resulted in the release of the same neutrophil chemotactic ...purified human alpha 1AT was able to prevent the neutrophil elastase from ...
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Neutrophil mediated injury to endothelial cells Enhancement by endotoxin and essential role of neutrophil elastase
... purified human neutrophil elastase, and different from that induced by hydrogen peroxide ...Further, neutrophil-mediated injury was not inhibited by scavengers of a variety of oxygen radical ...
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Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture
... Effect of varying cell number on gel contraction and collagen degradation. Collagen gels were prepared with co cultures containing varying concentrations of either monocytes or fibroblasts. The gels were then floated in ...
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Chemotactic responses of fibroblasts to tropoelastin and elastin derived peptides
... either human aortic elastin with human neutrophil elastase or from bovine ligament elastin with pancreatic elastase, elicited chemotactic responses that were maximal at ...
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Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate
... on neutrophil oxidative burst activity as measured by the conversion of DHR 123 to rhodamine ...stimulated neutrophil production of hydrogen peroxide, DFP ...
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The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease
... AD is the most common cause of dementia and the sixth leading cause of death in the USA [11]. The two major pathological hallmarks of AD are the presence of senile plaques containing amyloid beta (Aβ) peptides and tau ...
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Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: Implications for treatment
... pancreatic elastase. interestingly, the pancreatic elastase is generated from pro-elastase by tryptic cleav- age of an n-terminal activation peptide, whereas no pro-enzyme has been detected for the ...
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Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses
... for neutrophil elastase [25], and is expressed on a var- iety of cells including airway epithelial cells, fibro- blasts, myocytes, sensory neurons, and bronchial and vascular smooth muscle ...
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Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha 2 macroglobulin
... the elastase and antielastase activity of the alveolar fluid of seven patients with the adult respiratory distress syndrome (ARDS) and thirteen normal ...antineutrophil elastase activity was also ...
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A critical role for neutrophil elastase in experimental bullous pemphigoid
... Tissue damage caused by exogenous NE was also assessed using an in vitro system. Neonatal mouse skin sections (2 × 2 mm) were incubated with purified human NE (100 µg/mL in MEM) and examined histo- logically at ...
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Modulation of airway inflammation in cystic fibrosis In vivo suppression of interleukin 8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor
... rSLPI. Human bronchial epithelial cells exposed to CF ELF recovered before rSLPI therapy expressed IL-8 mRNA transcripts, but ELF recovered after rSLPI therapy induced far less bronchial epithelial cell IL-8 gene ...
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Neutrophil Elastase Inhibitors and Chronic Kidney Disease
... In human bronchial epithelial (16HBE) cell line, neutrophil elastase induces miR-146a and MUC5AC (mucin 5AC, oligomeric mucus/gel-forming) mucin expression in a dose- and time-dependent ...a ...
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