human parainfluenza virus
Adaptation of Human Parainfluenza Virus to Airway Epithelium Reveals Fusion Properties Required for Growth in Host Tissue
... includes human parainfluenza virus type 3 (HPIV3), cause the majority of childhood croup, bronchiolitis, and pneumonia ...differentiated human airway epithelium (HAE) cultures and in ...HPIV3 ...
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Antigenic and structural properties of the hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3: sequence analysis of variants selected with monoclonal antibodies which inhibit infectivity, hemagglutination, and neuraminidase activities.
... 5 Antigenic and Structural Properties of the HemagglutininNeuraminidase Glycoprotein of Human Parainfluenza Virus Type 3: Sequence Analysis of Variants Selected with Monoclonal Antibodie[r] ...
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An infectious clone of human parainfluenza virus type 3.
... the human parainfluenza virus type 3 (HPIV-3) genome (called pHPIV-3) was constructed, and recombinant, infectious HPIV-3 was generated by transfecting pHPIV-3 and support plas- mids encoding the ...
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A Leucine Residue in the C Terminus of Human Parainfluenza Virus Type 3 Matrix Protein Is Essential for Efficient Virus-Like Particle and Virion Release
... Having observed that the M protein of HPIV3 was capable of forming VLPs when expressed independently in cell culture, we sought to determine whether the HPIV3 M protein possessed a known L domain that was required for ...
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Proteins associated with human parainfluenza virus type 3.
... The viral origin of the polypeptides was further confirmed by immunoprecipitation of infected cell lysates with rabbit hyperimmune antisera against the envelope and core fractions of pur[r] ...
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Chimeric Bovine/Human Parainfluenza Virus Type 3 Expressing Respiratory Syncytial Virus (RSV) F Glycoprotein: Effect of Insert Position on Expression, Replication, Immunogenicity, Stability, and Protection against RSV Infection
... per virus isolated by limiting dilution, we identified five mutant variants that each had a different single mutation in HN, including the H552Q mutation noted ...high virus concentrations and serial ...
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Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3
... firmed this and showed that the IFN-␥-induced IDO caused se- vere inhibition of PIV3 (Fig. 7A). We conclude that regardless of whether it is expressed by recombinant means or by induction with an agonist, IDO can act as ...
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Identification of a natural human serotype 3 parainfluenza virus
... Human parainfluenza virus (HPIV) is known to induce acute respiratory infections (ARI) including lower respiratory tract infection, which is a leading cause of morbidity and mortality in infants and ...
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Prevalence of Viral Severe Acute Respiratory Infections in Patients in the Intensive Care Unit and Those under Mechanical Ventilation in Moi Teaching and Referral Hospital, Uasin Gishu County, Kenya
... influenza virus, rhinovirus, respiratory syncytial virus, Human Parainfluenza virus, Human metapneumovirus, adenovirus and Coronavirus in patients who are mechanically ventilated ...
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Features of Circulating Parainfluenza Virus Required for Growth in Human Airway
... prevalent human parainfluenza viruses, cause the majority of childhood croup, bronchiolitis, and pneumonia, yet there are currently no vaccines or effective ...of virus in immortalized cultured cell ...
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Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate
... syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are the first and second leading viral agents of severe respiratory tract disease in infants and young children ...
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Role of Matrix and Fusion Proteins in Budding of Sendai Virus
... Sendai virus (SV) membrane proteins in the production of virus-like ...of virus-like particles that contained M, as was previously observed with human parainfluenza virus type 1 ...
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The Second Receptor Binding Site of the Globular Head of the Newcastle Disease Virus Hemagglutinin-Neuraminidase Activates the Stalk of Multiple Paramyxovirus Receptor Binding Proteins To Trigger Fusion
... syncytial virus (RSV) and human metapneumovirus (hMPV), also possess a third, crit- ical function: they activate the F protein to mediate the merger of the viral envelope with the host cell ...measles ...
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A Chimeric Human-Bovine Parainfluenza Virus Type 3 Expressing Measles Virus Hemagglutinin Is Attenuated for Replication but Is Still Immunogenic in Rhesus Monkeys
... Measles virus is a member of the genus Morbillivirus of the Paramyxoviridae family of viruses ...Measles virus infection causes the death of over 1 million children per year and re- mains among the most ...
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Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response
... cancer. Virus vectors, usually replication-deficient viruses, still activate a stress re- sponse within the infected cell, which is often stronger than the response activated by wild-type viruses ...Sendai ...
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A novel broad spectrum treatment for respiratory virus infections : influenza based defective interfering virus provides protection against pneumovirus infection in vivo
... B virus in vivo through stimulation of type I interferon ...A virus [39, ...seasonal human influenza viruses but not with highly pathogenic H5N1 avian influenza ...strains, virus titres in the ...
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Natural and induced variation in the fusion glycoprotein gene of human respiratory syncytial virus subgroup A
... and human RS virus suggests that it could relate to host specificity (Lerch et ...all human isolates (Mufson et ...homogeneous virus population (Collins, ...of human RS viral escape ...
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Vaccines: the Fourth Century
... the human rotaviruses that cause infantile gastroen- teritis ...This virus was coin- fected in cell cultures with human rotaviruses of the four predominant G serotypes that are defined by the ...
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Rapid and Sensitive Method Using Multiplex Real Time PCR for Diagnosis of Infections by Influenza A and Influenza B Viruses, Respiratory Syncytial Virus, and Parainfluenza Viruses 1, 2, 3, and 4
... Currently, viral culture usually in combination with immu- nofluorescence (IF) is the “gold standard” for laboratory di- agnosis. However, it is not a rapid diagnostic test, and there- fore, its clinical value is ...
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Diversity of upper respiratory tract infections and prevalence of Streptococcus pneumoniae colonization among patients with fever and flu like symptoms
... As one of the most densely populated provinces in China, Zhejiang has been the center of attention for emerging infectious diseases since the H7N9 bird flu outbreak first started there in early 2013 [8]. Since then, ...
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