Human Platelets
Analysis of adenoviral attachment to human platelets
... to human platelets. Platelets were isolated from platelet-rich plasma as described in Materials and ...Methods. Platelets were incubated with Ad (MOI = 10, 1 hr, RT), followed by a thorough ...
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The Chemiluminescence Response of Human Platelets
... Human platelets and platelet particulate fractions were found to emit a burst of chemiluminescence during incubation with arachidonic ...of platelets in the reaction mixture and varied little for the ...
9
Modulation of the Random Migration of Human Platelets
... of human platelets has been recognized as a parameter of platelet function which can be assessed in a reproducible manner by modification of the Boyden micropore filter technique for evaluating this ...
8
The biosynthesis of phosphatidylinositol in human platelets
... Homogenates of human platelets can mediate the synthesis of phosphatidylinositol from myoinositol and cytidine diphosphate diglyceride. The cytidine diphosphate diglyceride: myoinositol, phosphatidyl ...
8
The interaction of bovine factor VIII with human platelets
... of human platelets with purified bovine Factor VIII caused three types of aggregation: (a) primary agglutination; (b) secondary aggregation involving the platelet release reaction; and (c) ...
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The perturbation of thrombin binding to human platelets by anions
... of human 125I-thrombin for platelets wer observed in various isotonic buffers at pH ...to platelets nor on E-PHA or collagen-induced serotonin ...
7
THE ROLE OF CHELATION AND OF HUMAN PLASMA IN THE UPTAKE OF SEROTONIN BY HUMAN PLATELETS
... The problem of serotonin uptake by human platelets was approached 1 by a screening method which defined certain systems in which dye DIPH reduction by intact human platelets in vitro was[r] ...
9
Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes A radioligand binding study of human platelets
... investigated. [125I]BOP was competitively displaced from its platelet binding site by stable TXA2/PGH2 analogues. Competition curves were shallow with Hill coefficients of -0.73 +/- 0.05 (P less than 0.001 different from ...
10
Binding of the products of prothrombin activation to human platelets
... to human platelets was tested with 125-I-labeled protein ...to platelets under conditions in which high affinity binding of thrombin was observed,nor did they cause platelet aggregation or serotonin ...
6
Biosynthesis of cytidine diphosphate diglyceride by human platelets
... of human platelets contain an enzyme which catalyzes the formation of cytidine diphosphate diglyceride from cytidine triphosphate and phosphatidic ...
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Pathways of fatty acid metabolism in human platelets
... with human platelets, has been ...Intact platelets have a considerable capacity to oxidize fatty ...with platelets, each showed a distinctive pattern of uptake among neutral lipids and ...
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Thrombin induced protein phosphorylation in human platelets
... The fact that phosphorylation of peak 7 protein is stimulated by cAMP with the fractionated enzyme while cAMP has no effect on peak 7 protein phosphorylation in crude sonicates as well a[r] ...
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Superoxide production and reducing activity in human platelets
... of platelets may have in vitro significance for platelet and leukocyte concentration and storage and in vivo significance for hemostasis, coagulation, and ...
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Binding of collagen alpha1 chains to human platelets
... induced by alpha1 and the binding of alpha1 by washed intact platelets are correlated. The biochemical studies showed that the binding of the alpha1 chain to washed intact platelets was platelet ...
8
Heterogeneity of human Platelets: I Metabolic and kinetic evidence suggestive of young and old platelets
... volume per platelet of the separated large-heavy and light-small platelet populations was 12 and 5 µ 3 respectively. When data are expressed per milliliter platelets or per gram wet weight, the large-heavy ...
11
Lipid metabolism in human platelets: II De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis
... returned to that seen in platelets incubated with glycerol alone. Purified human thrombin also produced this same effect on phospholipid synthesis in platelets. Trypsin produced effects on ...
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STUDIES ON PLATELETS XIV HUMAN PLATELETS AS SOURCE OF ANTIFIBRINOLYSIN
... Antifibrinolytic activity was evidently higher in patients with increased number of platelets and in healthy subjects than in patients with quantitative idiopathic thrombocytopenic purpu[r] ...
8
Thrombospondin induced adhesion of human platelets
... thrombasthenic platelets, which lack GPIIb-IIIa, adhered to TSP to the same extent as anti-GPIIb-IIIa-treated normal platelets or 40-60% as well as untreated normal ...thrombasthenic platelets by ...
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Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets
... to platelets can be competitively inhibited by unlabeled human or bovine FVIII/vWF, but not by human thrombin, fibrinogen, alpha 2-macroglobulin, equine collagen, or a lectin of Ricinus ...
10
Heterogeneity of human platelets: II Functional evidence suggestive of young and old platelets
... large-heavy platelets compared with light-small platelets, and large-heavy platelets released ...large-heavy platelets released ...light-small platelets. After platelet aggregation by ...
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