Human polymorphonuclear leukocytes
Oxidation of Methionine by Human Polymorphonuclear Leukocytes
... phagocytosing human polymorphonuclear leukocytes (PMN), but not resting PMN, oxidized both intracellular and extracellular methionine to methionine ...
11
BACTERICIDAL FUNCTION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES
... : In vitro bactericidal capacity of human polymorphonuclear leukocytes: Di- minished activity in chronic granulomatous. disease of childhood[r] ...
9
Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli Evidence that the same oxidase is activated by different transductional mechanisms
... Activation of the Respiratory Burst Enzyme in Human Polymorphonuclear Leukocytes by Chemoattractants and Other Soluble Stimuli EVIDENCE THAT THE SAME OXIDASE IS ACTIVATED BY DIFFERENT TR[r] ...
10
Oxidative cross linking of immune complexes by human polymorphonuclear leukocytes
... of human serum albumin-anti-human serum albumin immune complexes bound to a plastic surface, with human polymorphonuclear leukocytes for 1 h at 37 degrees C resulted in covalent ...
11
The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes
... Human polymorphonuclear leukocyte (PMN) elastase has been implicated in various pathological conditions. However, its physiological role remains undefined. One possible function of this enzyme may be ...
10
Rapid changes in light scattering from human polymorphonuclear leukocytes exposed to chemoattractants Discrete responses correlated with chemotactic and secretory functions
... polymorphonuclear leukocyte suspensions evoked a single wave of increased light transmission, whereas the perpendicular scattering measurement demonstrated a previously unrecognized biphasic response. The first ...
11
Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes Effects on activation of NADPH oxidase
... To investigate the effect ofvarious concentrations of propranolol on the generation of PLD-derived products, PA and DG, and to examine correlations between PA and/or DG and the activatio[r] ...
10
The effects of disodium pamidronate on human polymorphonuclear leukocytes and platelets: An in vitro study
... Abstract: Recent reports have indicated that, as well as having antiresorptive effects, bisphosphonates could have an application as anti-inflammatory drugs. Our aim was to investigate whether this anti-inflammatory ...
9
Evidence that proteases are involved in superoxide production by human polymorphonuclear leukocytes and monocytes
... polymorphonuclear leukocytes (PMN) and monocytes was explores using various protease inhibitors and ...by human PMN and monocytes induced by cytochalasin E and concanavalin A, though PMN were more ...
9
Granulocyte macrophage colony stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes
... Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known as an inducer of proliferation and functional activation of myeloid cells. This study was carried out to characterize the effects of GM-CSF on ...
6
Further characterization of NADPH oxidase activity of human polymorphonuclear leukocytes
... Activity was present in granules iso- Mn2", it seemed necessary to examine the effect of superlated from cells challenged with opsonized zymosan, oxide on the Mn+-catalyzed oxidation of [r] ...
8
Evidence that the superoxide generating system of human leukocytes is associated with the cell surface
... the polymorphonuclear leukocyte plasma membrane, we have examined the effects upon O-2- production of p-diazobenzenesulfonic acid, a reagent which can react predominantly with proteins of the external cell ...
7
In vitro model of intestinal crypt abscess A novel neutrophil derived secretagogue activity
... inflammation, human polymorphonuclear leukocytes (PMN) were layered onto monolayers of the human intestinal epithelial cell line T84, a crypt-like epithelium which is capable of Cl- ...the ...
5
In vitro suppression of serum elastase inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes
... Human polymorphonuclear leukocytes (PMN) phagocytosing opsonized antigen-antibody complexes, produce dialyzable species of activated oxygen which are capable of partially suppressing the ...
6
Interaction of human monocytes, macrophages, and polymorphonuclear leukocytes with zymosan in vitro Role of type 3 complement receptors and macrophage derived complement
... fragments of anti-C3 antibodies and monoclonal antireceptor antibodies M01 and OKM10. In contrast, antibody IB4, which binds to a receptor epitope distinct from the binding site, does not inhibit zymosan uptake. ...
10
Hydrogen peroxide generation by polymorphonuclear leukocytes exposed to peritoneal dialysis effluent.
... Recurrent bacterial peritonitis remains the primary reason for the termination of treatment of end-stage renal failure by continuous ambulatory peritoneal dialysis (CAPD). Peritonitis is characterized by an influx of ...
7
Human Cytomegalovirus Replicates Abortively in Polymorphonuclear Leukocytes after Transfer from Infected Endothelial Cells via Transient Microfusion Events
... In the present study, using a recently developed in vitro model for generation of pp65-positive PMNLs (27), we showed that virus and viral (as well as cellular) material detected in PMNLs are transferred from permissive ...
10
Phagocytic Function of Polymorphonuclear Leukocytes in Rheumatic Diseases
... Phagocytosis of yeast particles by peripheral blood and synovial fluid neutrophils was compared in the sera and synovial fluids from 16 osteoarthritis, 23 rheumatoid arthritis, and 12 mi[r] ...
5
Substance P recognition by a subset of human T lymphocytes
... with human blood T-lymphocytes, which stimulates T- lymphocyte proliferation, was quantified by both flow cytometric and direct binding ...of human blood T-lymphocytes before and after stimulation with 10 ...
9
Viricidal effect of polymorphonuclear leukocytes on human immunodeficiency virus 1 Role of the myeloperoxidase system
... neutrophilic polymorphonuclear leukocytes (PMN) effective against a variety of ...Normal human PMN, when stimulated with phorbol myristate acetate or opsonized zymosan, are viricidal to ...
5