Human recombinant tumor necrosis factor
Treatment with recombinant human tumor necrosis factor alpha protects rats against the lethality, hypotension, and hypothermia of gram negative sepsis
... of recombinant human TNF-alpha (100 micrograms/kg) to rats undergoing CLP 1 d after the treatment period resulted in a significant reduction in mortality compared to control rats previously unexposed to ...
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Cachectin/Tumor Necrosis Factor
... Clinical trials of recombinant human CachectinTrNF are underway. Phase-I studies confirmed many of the observations initially made in animals; profound systemic and organ specific toxicity has been ...
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Recombinant human tumor necrosis factor alpha Regulation of N formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils
... concentrations of N-formylmethionylleucylphenylalanine (FMLP). Enhanced superoxide anion production was evident by 5 min and had reached a plateau by 15 min. Not only was the total amount of superoxide anion released ...
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Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment
... and tumor necrosis factor- α (TNF- α ) were detected in the cerebrospinal fluid (CSF) from SAH patients by enzyme-linked immunosorbent assay ...(IHC). Recombinant human PGRN (r-PGRN) or ...
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The 55 kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor alpha and by ultraviolet B radiation
... of human keratinocytes critically depended on regulation of 55-kD TNFR ...expression. Human keratinocyte 55-kD TNFR surface and mRNA expression was found to be regulated in vitro by recombinant ...
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Human granulocyte macrophage colony stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes
... by recombinant GM-CSF(rGM-CSF)-treated U937 cells was found to exert an inhibitory effect on subsequent U937 colony growth that was partially due to the presence of tumor necrosis factor ...
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Effect of Tumor Necrosis Factor on Body Systems
... the factor that may differ also in their biological ...and human TNF-β is highly homologous (74 %). Recombinant human proteins with deletions of 27 amino acids from the N-terminus appear to be ...
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Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation
... and tumor necrosis factor ...formation. Recombinant IL-1 and recombinant TNF were both shown to stimulate T cell colony growth in a dose-dependent manner, and this stimulation could be ...
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Regulation of human lung fibroblast glycosaminoglycan production by recombinant interferons, tumor necrosis factor, and lymphotoxin
... of recombinant (r) tumor necrosis factor (TNF), lymphotoxin (LT), and gamma, alpha, and beta 1 interferons (INF-gamma, -alpha and -beta 1), alone and in combination, on GAG production by ...
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Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice
... Among recombinant mouse IFN gamma, human IL1 alpha, human IL2, mouse granulocyte-macrophage colony-stimulating factor and human TNF alpha, only human TNF alpha suppressed ...
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High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia
... immunoassays using nonblocking anti-receptor antibodies and 125I-recombinant human TNF alpha. As compared to the titers observed in 25 healthy controls, TNFBP types A and B titers were found to be elevated ...
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Tumor necrosis factor and immune interferon synergistically induce cytochrome b 245 heavy chain gene expression and nicotinamide adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells
... Recombinant tumor necrosis factor (rTNF) and rIFN-gamma induce in the human leukemia cell lines HL-60, ML3, and U937 the accumulation of transcripts of the X chromosome- linked chronic ...
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Effect of recombinant human tumor necrosis factor alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide
... of tumor necrosis factor-alpha in the central nervous system in a rabbit ...of recombinant human TNF into the cisterna magna in the rabbit led to an acute reduction in cerebral oxygen ...
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Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue
... Tumor necrosis factor (TNF, cachectin) is a macrophage product that has been suggested to signal the loss of body weight, the decrease in adipose tissue and muscle mass, and anorexia during ...
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Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin 25 Mediated Protection from Amebic Colitis
... Recombinant IL-25 treatment. Mice were injected intraperitoneally with 0.5 g recombinant IL-25 (R&D Systems) or 100 l PBS each day for 4 days before and through 4 days after E. histolytica ...
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Tumor necrosis factor expression in human epithelial tumor cell lines
... Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor ...epithelial tumor cell ...14 tumor cell lines has detectable levels of high ...
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Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... Tumor necrosis factor alpha (TNF-α) plays a central role in inflammatory processes, immune regulation and ...pathogenic factor in various diseases, including sepsis, cancers, as well as ...
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Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines
... from human monocytes can stimulate these processes when added to isolated rat ...pure recombinant IL-1 and other monokines has allowed us to investigate the identity of the active agent in this ...with ...
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Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha Downregulating Genes for the Development of Antituberculous Vaccines
... logical factor in humans, as reflected by the enhanced susceptibil- ity to ...in human TB has prompted extensive investigative efforts to study the role of TNF in shaping the immune response during ...
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Tumor necrosis factor reduces Plasmodium falciparum growth and activates calcium signaling in human malaria parasites
... activities of TNF are mediated by two distinct cell-surface receptors: tumour-necrosis factor receptor-1 or 2 (TNFR1 and TNFR2). Ligand binding to TNFR complexes induces intracellular signal transduction. ...
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