Human regulatory B cells
Human regulatory B cells in health and disease: therapeutic potential
... which B cells differentiate plays a pivotal role in the induction of ...and B cell activating factor (BAFF) (18, 32, 33, 35, 80, ...than regulatory B cell ...of B cells to ...
9
The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis.
... isolated B cells from MG patient-derived PBMCs and in vitro expansion in drug medium and comparison with non-drug medium; method (2) Once ex vivo expansion of MG Bregs is completed then the adoptive ...
14
Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer
... with human regulatory T cell Cocktail (BD PharMingen, USA) [20] and Bregs identified with CD19 + CD24 hi CD27 + expression were stained with hu- man anti-CD19, human anti-CD24, and human anti- ...
11
Regulatory B Cells Are Inversely Associated with Disease Activity in Rheumatoid Arthritis
... T cells, together with increased levels of BAFF in active arthritis, comprise an inflammatory milieu in RA that favors the production of IL-10+ regulatory ...IL-10+ B cell induction may be impaired ...
5
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
... a B cell– specific molecule that is first expressed on the cell surface during the pre-B to immature B cell transition but is lost upon plasma cell differentiation (23, ...of B cell depletion ...
12
Human Mesenchymal Stem Cell-Treated Regulatory CD23+CD43+ B Cells Alleviate Intestinal Inflammation
... these cells could contribute to the therapeutic effect of hMSCs on mice with TNBS-induced ...inflammatory cells in the submucosa in the colons of TNBS-treated mice (Figure ...used human dermal ...
15
Review Article Regulatory T cells and B cells: implication on autoimmune diseases
... (Treg) cells play an essential role in the maintenance of homeostasis and prevention of autoimmune responses ...these cells are CD4+ cells that express CD25, an IL-2 receptor alpha chain and other ...
7
Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5+ B regulatory cells
... + B cells increased significantly after hUC-MSC ther- ...Th cells and Tregs, inducing T-cell and B-cell apoptosis, and inhibiting other immune-related cells, including CD8 + T ...
12
BANK1 alters B cell responses and influences the interactions between B cells and induced T regulatory cells in mice with collagen induced arthritis
... on B cells from the spleen and lymph nodes in mice with established arthritis on the 35th day after immunization ...2a). B cells, which secrete antibodies in the humoral immune system and ...
13
Paradox of B cell–targeted therapies
... that B cells can also be essential for suppressing unwanted autoaggressive T cell responses, and therefore, a more careful evaluation of which types of autoimmune disorders this therapy should be utilized ...
5
IL 10 producing regulatory B cells (B10 cells) in autoimmune disease
... of cells infused during adoptive transfer experiments is ...PRO cells prior to ex vivo expansion is obviously peripheral ...PRO cells are rare in peripheral blood and there are limitations on the ...
12
Regulatory B cells in allergic asthma and schistosomiasis : controlling inflammation
... The human body is continuously exposed to a variety of environmental insults at mucosal surfaces via inhalation or ...dendritic cells (DCs) are constantly patrolling the environment, looking for danger ...T ...
171
Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation
... B cells are classically defined as antibody-producing cells; however, it is well established that these cells display several other functions, such as antigen presentation and cytokine ...
11
Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells
... T cells play a crucial role in the homeostasis of the immune ...+ regulatory T cells, several subsets of Foxp3 - regulatory T cells, such as T helper 3 (Th3) cells and type 1 ...
8
B Cells with Regulatory Function in Animal Models of Autoimmune and Non Autoimmune Diseases
... of B cell subsets with negative regulatory functions and the definition of their mechanisms of action are recent events, the important negative regulatory roles of B cells in immune ...
10
Aberrant populations of circulating T follicular helper cells and regulatory B cells underlying idiopathic pulmonary fibrosis
... Tfh cells and/or decreases of Breg cells in the peripheral ...Tfh cells and Breg cells in the peripheral blood may provide a useful marker for identifying this ...of B cells, ...
9
Follicular regulatory T cells inhibit the development of granzyme B–expressing follicular helper T cells
... TFR cells repress a cytotoxic gene program in TFH ...TFH cells were isolated by FACS, RNA was then prepared and subjected to ...TFH cells compared with WT TFH cells, and Gzmb is increased ...
12
Immunomodulatory Effects of Human Adipose Tissue-derived Mesenchymal Stem Cells on T Cell Subsets in Patients with Rheumatoid Arthritis
... Th17 cells in the treatment of some autoimmune diseases, in which Th17 cells are recognized as key ...naïve human CD4 + T cells from the IL-17 producing cells into the expansion of a ...
6
Dysregulation of peritoneal cavity B1a cells and murine primary biliary cholangitis
... sorting purity was greater than 96%. Cells were suspended in TRIzol and total RNA extracted with an RNeasy Mini Kit (Qiagen, Hilden, Germany) and hybridized to Agilent chips. Fluorescence was detected using the ...
15
Activation of human B cells by phosphorothioate oligodeoxynucleotides
... probe, specific for PCR products amplified with a given primer pair. Hybridization was conducted in Rapid-hyb buffer (Amersham LIFE SCIENCE, Little Chalfont, UK) at 428C. Blots were washed in 0.13 SSC and 0.1% SDS at ...
12