human soluble CD40 ligand
Soluble CD40 ligand and prolactin levels in migraine patients during interictal period
... Although prolactin has been reported to create a ten- dency to the cardiovascular diseases [45–48], our study demonstrated no correlation of prolactin with sCD40L and hs-CRP. It is known that increased prolactin levels ...
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Internalization of IgG-Coated Targets Results in Activation and Secretion of Soluble CD40 Ligand and RANTES by Human Platelets
... Using flow cytometry, platelets were further assessed for their ability to internalize IgG-coated beads. Platelets were exposed to FITC-IgG-coated polystyrene beads (or FITC- BSA-coated polystyrene beads as a control) on ...
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Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro
... the human and monkey genomes are highly similar, the small differences noted be- tween monkey and human protein sequences are often suffi- cient to elicit neutralizing antibodies when the human ...
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Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma
... sCD40L serum levels were measured by the Quantikine Human CD40 Ligand Immunoassay (R&D Systems, Inc., Minneapolis, MN, USA) following the manufacturer’s instructions. Optical density was ...
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CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally replicating adenovirus
... encoding human CD40L (RAdCD40L), which results in expression of ligand at the cell mem- ...Fas ligand mutated to resist cleavage from the cell mem- brane delivers a more potent apoptotic stimulus ...
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Soluble CD40 ligand and Oxidative Response are Reciprocally Stimulated during Shiga Toxin-associated Hemolytic Uremic Syndrome.
... release soluble CD40 ligand (sCD40L) which in turn contributes to oxidative imbalance, triggering the release of reactive oxidative species (ROS) on various cellular ...Activated human ...
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Soluble CD40 ligand activated human peripheral B cells as surrogated antigen presenting cells: A preliminary approach for anti HBV immunotherapy
... In this study, we used recombinant human GMP-qual- ity trimeric soluble CD40L to activate PBMC-derived B cells. We established and optimized the culture system for CD40L-B cells, which allows B cell ...
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Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma
... CD40 ligand (CD40L) was initially identified as a T-cell receptor for ligation of the co-stimulatory molecule CD40, and CD40-CD40L interaction was considered as a key event for effective ...
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Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis
... difference in the survival at 30 days with the use of sta- tins previously to the diagnosis of severe sepsis; and it was not possible to explore the effect of this agent group during the sepsis because in all patients ...
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The soluble CD40 ligand sCD154 in systemic lupus erythematosus
... After informed consent, blood was obtained from patients (22–69 years old) who satisfied diagnostic cri- teria of the American College of Rheumatology (ACR) for SLE (29) or from normal age-matched control donors. Whole ...
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Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines
... humans, human immunodeficiency virus (HIV) DNA vaccines may need to include immunostimulatory adjuvant ...molecules. CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily ...
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High levels of soluble CD40 ligand and matrix metalloproteinase 9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis
... on CD40-CD40L interaction [11,38]. Moreover, CD40-CD40L simultaneously with TNF-α is a potent inducer of nitric oxide production, which plays a main role in antimicrobial ...
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Hyper IgM syndrome type 4 with a B lymphocyte–intrinsic selective deficiency in Ig class switch recombination
... B cell activation and in vitro CSR. B cell activation and in vitro CSR were performed as described previously (12, 14). We used a combination of soluble CD40L (sCD40L) and recombinant interleukin-4 (rIL-4), which ...
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Abnormal CD40 Ligand (CD154) Expression in Human Immunodeficiency Virus-Infected Children
... the CD40 receptor on B cells and other antigen-presenting cells leads to the up-regulation of costimulatory molecules such as CD80 on the antigen-presenting cells, which leads to increased T-cell activation and ...
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Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study
... [15]. Soluble CD40 ligand (sCD40L), a member of the TNF family produced by activated platelets, upregulates the expression of inflammatory adhesion receptors and cellular activators, and circulates ...
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Bürger, Christina (2017): Cell type-specific CD40-CD40L interaction in atherosclerosis. Dissertation, LMU München: Medizinische Fakultät
... of CD40 and CD40L and the crucial role of both, receptor and ligand, in T cell-dependent B cell differentiation and activation could be ...of CD40 and CD40L, by using blocking antibodies which ...
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Serum neutrophil gelatinase associated lipocalin and resistin are associated with dengue infection in adults
... of soluble intercellular cell adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1), which may regulate the activation and dam- age of endothelial cells ...Fas/Fas ligand ...
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<p>Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?</p>
... special parameter estimation. Serum samples were left for clotting, and then were centrifuged at 3,000 rpm for 20 minutes. Serum was separated and divided into three portions: one for routine parameter estimation (random ...
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Striking Similarity of Murine Nectin-1α to Human Nectin-1α (HveC) in Sequence and Activity as a Glycoprotein D Receptor for Alphaherpesvirus Entry
... Identification of cell surface molecules that are principally responsible for the entry of HSV into specific cells of organized tissues in the intact mouse or human will require several com- plementary approaches. ...
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Cyclosporin A inhibits CD40 ligand expression in T lymphocytes
... concentration. CD40 ligand expression was inhibited by pretreatment of T cells with cyclosporin ...inhibited CD40 ligand expression with a potency mirroring the ability of each compound to ...
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