human tissue plasminogen activator
Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian Patients Patients
... Background: Hypercoagulability and hypofibrinolysis are among the symptoms exhibited by diabetic patients. Our study aimed to address the polymorphic nature of Alu DNA fragment in the human tissue ...
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Tissue plasminogen activator promotes platelet disaggregation in plasma
... of human platelets by tissue-type plasminogen activator (t- ...of human platelets induced to aggregate in plasma with adenosine 5'-diphosphate, t-PA promoted disaggregation of platelets ...
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Behçet’s disease: new insight into the relationship between procoagulant state, endothelial activation/damage and disease activity
... (AssayMax Human Thrombin-antithrombin Complexes ELISA Kit, ASSAYPRO, ...of tissue-type plas- minogen activator (t-PA) (TriniLIZE tPA antigen ELISA kit) and plasminogen activator ...
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Structural and kinetic comparison of recombinant human single and two chain tissue plasminogen activator
... recombinant human single-chain tissue plasminogen activator (sct-PA) and two-chain tissue plasminogen activator (tct-PA), and compared these structural data with ...
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Tissue type plasminogen activator increases the binding of glu plasminogen to clots
... Porcine tissue-type plasminogen activator (t-PA) increases the binding of 125I-glu- plasminogen to clots made from human plasma or purified fibrinogen in a time and t-PA concentration ...
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Studies of thrombin induced proteoglycan release in the degradation of human and bovine cartilage
... measurements of the levels of inhibitor-enzyme complexes and several other proteins associated with coagulation and fibrinolysis. The concentrations of 13 plasma proteins and complexes of thrombin and Factor Xa with ...
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Influence of the fast acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue type plasminogen activator in rabbits Interference of tissue derived components
... of plasminogen activator (PA-inhibitor) on thrombolysis was investigated in rabbits with a jugular vein ...of human tissue-type plasminogen activator (t-PA) produced similar ...
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Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface
... from human blood plasma by using barium sulfate and extrac- tion with EDTA solution and examined their ability to influence the generation of plasmin on platelets ...the plasminogen activation process on ...
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alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2.. Interactions between tissue-type plasminogen activator and extracellular matrix assoc[r] ...
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Endothelial cell mediated conversion of Glu plasminogen to Lys plasminogen Further evidence for assembly of the fibrinolytic system on the endothelial cell surface
... acid- plasminogen (Glu-PLG), displays enhanced binding affinity for fibrin and also enhanced activation by urokinase and tissue plasminogen ...as tissue plasminogen activator to ...
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Effect of urokinase antiserum on plasminogen activators: demonstration of immunologic dissimilarity between plasma plasminogen activator and urokinase
... between human urokinase and human milk activator or human tissue activator from adrenal sources but demonstrated immunologic identity between human urokinase and the ...
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Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells
... plasminogen activator concentration in conditioned medium was measured by a two-site radioimmunometric ...of tissue plasminogen activator. A sixfold increase in tissue ...
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Thrombolysis with human extrinsic (tissue type) plasminogen activator in dogs with femoral vein thrombosis
... (tissue-type) plasminogen activator (plasminogen activator) was isolated either as a single-chain or as a two-chain molecule from the culture medium of a human melanoma cell ...
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Thrombolysis with Human Extrinsic (Tissue Type) Plasminogen Activator in Rabbits with Experimental Jugular Vein Thrombosis EFFECT OF MOLECULAR FORM AND DOSE OF ACTIVATOR, AGE OF THE THROMBUS, AND ROUTE OF ADMINISTRATION
... (tissue-type) plasminogen activator, highly purified from the culture fluid of a human melanoma cell line, was administered systemically or locally over a time period of 4 h and the percent ...
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Thrombin induction of plasminogen activator inhibitor in cultured human endothelial cells
... of plasminogen activator (PA) and plasminogen activator-inhibitor (PA-I) in medium conditioned by primary cultures of human umbilical vein endothelial ...total tissue-type PA ...
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Binding of tissue plasminogen activator to cultured human endothelial cells
... involving binding sites of both high (Kd, 28.7 +/- 10.8 pM; Bmax, 3,700 +/- 300) and low (Kd, 18.1 +/- 3.8 nM; Bmax 815,000 +/- 146,000) affinity. t-PA binding was 70% inhibited by a 100-fold molar excess of u-PA. When ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
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Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction
... The only enzyme currently approved for VMT treatment is ocriplasmin (Jetrea) (ThromboGenics, Leuven, Belgium). Ocriplasmin is a fragment of human plasmin manufactured by genetic recombination techniques in Pichia ...
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Inhibition of angiogenesis by platelets in systemic sclerosis patients
... TGF-β, human lung fibro- blasts (WI-38, catalogue number CCL-75; ATCC) were cultured in 24-well plates in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10 % fetal bovine ...
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The neuroendocrine-like phenotype of gastric myofibroblasts and its significance in cancer.
... normal tissue including, for example, evidence of epigenetic changes in tumour-derived myofibroblasts (Jiang et ...normal tissue (stomach and oesophagus), from inflammatory, non-cancer, tissue ...
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