Human β-defensin 2
Human β-defensin-2 production from S. cerevisiae using the repressible MET17 promoter
... of human β-defensin-2 in shake flask cultures (SFC) using a highly productive ...recombinant human albumin (rHA); however, studies have shown that it can also be used to express a ...
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Fecal human β-defensin-2 (hBD-2) levels and gut microbiota patterns in preterm neonates with different feeding patterns
... Human β-defensin 2 levels. This study showed that hBD-2 levels in the formula milk predominant group were significantly higher compared with the breast milk only ...milk. Human ...
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Isoleucine, an Essential Amino Acid, Induces the Expression of Human β Defensin 2 through the Activation of the G Protein Coupled Receptor ERK Pathway in the Intestinal Epithelia
... It has been proposed that the defensins expression de- crease in patients with CD [5,14]. Therefore, the induc- tion of HBD2 by the administration of Ile is a possible option to treat CD. We also confirmed that oral ...
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Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide
... primary human tra- cheobroncial cells shows a clear increase in HBD2 protein in response to LPS by western blotting, although another recent study in primary airway epithelial cells reports low expression of MD2 ...
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Keratinocyte Expression of Human β Defensin 2 following Bacterial Infection: Role in Cutaneous Host Defense
...  defensin 2 (hD-2) is a cationic antimicrobial peptide (CAP) found in the skin and is thought to play impor- tant roles in cutaneous host immune defense and numerous disease ...
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Human β defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen specific immunity
... HBD 2-conjugated RBD treatment in THP-1 cells sig- nificantly (p < ...HBD 2 conjugation ...HBD 2-conjugated Ag treatment and remained strongly induced 24 h after Ag treatment ...HBD ...
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Vaginal innate immune mediators are modulated by a water extract of Houttuynia cordata Thunb
... including human β -defensin 2 (hBD2) and secretory leukocyte protease inhibitor (SLPI), as well as cytokines and chemokines that play vital roles in mucosal innate immunity of the female ...
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THE RELATIONSHIP BETWEEN INTESTINAL PROTECTIVE MARKERS AND SERUM ENDOTHELIN 1 CONCENTRATIONS IN LOW BIRTH WEIGHT INFANTS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY
... mucin 2 (MUC2), serum intestinal trefoil factor (ITF), and faecal human β-defensin 2 (HBD2), and a marker of endothelial activity, ...(group 2), and 20 control infants using ...
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Vitamin D nutritional status and vitamin D regulated antimicrobial peptides in serum and pleural fluid of patients with infectious and noninfectious pleural effusions
... and β- defensin-2 levels were measured by ELISA using the following kits: Quantikine Human Vitamin D Binding Protein (R&D Systems Europe, Abingdon, UK), HK321 Human LL-37 (Hycult ...
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Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae
... proteins, human milk lysozyme (Sigma, St. Louis, MO), human milk apo-lactoferrin ...MO), human β defensin-1 and human β defensin-2 (Peptides International, ...
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Host Defense Peptides in Wound Healing
... receptor 2 and subsequent acti- vation of the NF-κB cascade induces human β-defensin 2 ...more, human Toll-like receptor 2 medi- ates induction of the antimicrobial pep- ...
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The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
... hBD: human β-defensin; HDACs: histone deacetylases; HDPs: host defense peptides; HEL: hen egg lysozyme; HIF-1-α: hypoxia-inducible factor 1-α; HLA- DR: human leukocyte antigen-antigen D ...
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Clinical application of human β defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation
... The current study demonstrates that patients with mod- erate to severe chronic periodontitis present more com- monly with the -1654 A/A genotype on the DEFB1 gene and the -159 T/T genotype on the CD14 gene, in paral- lel ...
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Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK TRAF6 p38MAPK signaling pathway in human middle ear epithelial cells
... secreted β-defensin functions as an chemoattractant for CCR6 positive immature dendritic and memory T cells, facilitating the transition from innate immunity to adap- tive immunity by producing inflammatory ...
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Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection
... -and β -defensins based on the connectivity of their six cystein residues ...[1]. Human β-defensins (hBDs) are expressed mainly in epithelial ...the β -defensin family, was iden- tified ...
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Effects of Stress on Mouse β Defensin 3 Expression in the Upper Digestive Mucosa
... the human stomach during non- Helicobacter pylori infection, suggesting another important antimicrobial mechanism in the ...hBD- 2 expression is much higher in the healthy esophagus than the ...
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Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae induced up regulation of human beta defensin 2 in middle ear epithelial cells
... normal human bronchial epithe- lial cells to Gram-positive group B Streptococci ...of β -defensin-2 by LPS [39] or activation of NF- κB by NTHi ...of β -defensin-2 in Hela ...
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PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat
... beta defensin-1, and ADRP by Orlistat (Figure 4) in Caco-2 cells along with the direct binding of Orlistat to PPARγ (Figure 2), is strong evi- dence that Orlistat is a PPARγ agonist since these genes ...
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Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain
... of defensin peptides (NP-1, -2, and −5) in infected rabbit ...inflamed human salivary gland ducts, but without a corresponding increase in hBD- 1 ...
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Fusobacterium nucleatum in Periodontal Health and Disease
... Several studies have shown susceptibility of bacteria to β-defensins. Some results showed that early microbial colonizers, even if they are very sensitive to these peptides, don’t upregulate them. For hβD-2 ...
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