humanized mouse
Development of a new humanized mouse model to study acute inflammatory arthritis
... the humanized mouse [4,9]. This humanized mouse model helped the progres- sion of studies on human-specific infectious diseases, such as HIV, Dengue virus and Salmonella typhi for which ...
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Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential
... blood-humanized mouse model that allows EBV-infected B cells to in- teract with CD4 T cells (the major source of CD40 ...blood-humanized mouse model, although the simultaneous loss of both ...
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The utilization of humanized mouse models for the study of human retroviral infections
... these humanized mouse models is clearly evident; however, the functionality of the system is under ...SCID mouse; however, the possibility of phenotypic changes, especially on cell-surface markers is ...
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Quantifying the effect of Vpu on the promotion of HIV 1 replication in the humanized mouse model
... cell-transplanted humanized mouse model infected with wild-type and vpu-deficient HIV-1 (HIV-1Δvpu [6, ...infected humanized mice, augmenting HIV-1 replication in vivo ...the humanized ...
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Humanized mouse model of Rasmussen’s encephalitis supports the immune mediated hypothesis
... Rare diseases, especially those like RE that affect pediatric populations, pose unique challenges for the development of therapies and for pathophysiological studies. In recognition of this, we generated a ...
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Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs
... a humanized mouse model consisting of NSG mice intrasplenically injected with activated human PBMC and HIV to study NK cell-mediated inhibition of acute HIV infection (21, ...SPHIR mouse spleens ...
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Humanized mouse models reveal an immunologic classification of idiopathic CD4 lymphocytopenia subtypes
... 2 humanized mouse models in which either HSCs or mature T cells from patients with ICL were removed from their human environment and placed in an in vivo system that allowed the study of the human lymphoid ...
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Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model
... a humanized mouse strain was evaluated as a potential preclinical model for studying human immune responses to HSV-2 infection and ...Immunodeficient mouse strains were examined for their abilities ...
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Antagonism of TIM 1 blocks the development of disease in a humanized mouse model of allergic asthma
... TIM-1 protein binding to DCs and blockade using anti–TIM- 1 mAbs. (A) Binding of murine TIM-1–Fc to bone marrow– derived murine myeloid DCs in the presence or absence of EGTA and the anti-mouse TIM-1 mAb 4A2. ...
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Evolution of the HIV-1 env Gene in the Rag2−/− γC−/− Humanized Mouse Model
... from mouse 6, showed a small but significant decrease in sensitivity to Leu3a, while the JRCSF I165K and D167N mutants, which exhibited intermediate sensitivities to the anti-V3 antibody, exhibited only a marginal ...
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Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection
... Dengue manifests in a wide spectrum of clinical symptoms ranging from mild dengue fever (DF) to life-threatening dengue hemorrhagic fever/dengue shock syn- drome (DHF/DSS). The symptoms of dengue are usually accompanied ...
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PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse
... Based on the negative prognostic role of PD-1/PD-L1 and the immune response associated with the PD-1 axis in the datamining analysis, we investigated whether blockade of the PD-1 axis could generate an antitumor effect ...
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HLA transgenic mice as humanized mouse models of disease and immunity
... Predisposition to type 1 diabetes is strongly associated with the presence of DQ8, while DQ6 has been found to be protective. The nonobese diabetic (NOD) mouse is an animal model for spontaneous diabetes. To ...
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Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model
... a unique opportunity to manipulate implanted immune cells and/or tumor to address mechanistic questions and test biologic hypotheses. As a proof of principal, we de- pleted CD8+ T cells from PBL prior to immune reconsti- ...
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HIV 1 infection, response to treatment and establishment of viral latency in a novel humanized T cell only mouse (TOM) model
... With the long-term goal of obtaining a better un- derstanding of HIV replication, CD4 + T cell depletion, HIV latency and persistence in vivo, we sought to study HIV-1 in a humanized mouse model that pos- ...
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Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials
... Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease.. Clin Exp Immunol.[r] ...
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TLR3 agonist and CD40 targeting vaccination induces immune responses and reduces HIV 1 reservoirs
... the humanized mouse model of persistent HIV-1 infection, we show here that a therapeutic vaccine target- ing HIV-1 antigens to CD40 combined with poly(I:C) activated the cART-resistant HIV-1 reservoir, ...
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PubMedCentral-PMC5021593.pdf
... Humanized mouse models have been used for almost three decades to study the effects of HIV infection in the CNS ...mice humanized by human CD34+ stem cell transplantation ...
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HIV Latency in the Humanized BLT Mouse
... a humanized mouse model that produces peripheral HIV latency is the possibility that it may be used for preclinical assess- ment of strategies for purging persistent HIV reservoirs from HAART-treated ...
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1-s2.0-S0149291819304047-main.pdf
... genetically humanized mouse strains can be powerful tools for modeling infection with some viral pathogens, for other viruses, such as HCV, several genes regulate host range, making it difficult to fully ...
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