hydrophobic domain
Identification of a Hydrophobic Domain of HA2 Essential to Morphogenesis of Helicoverpa armigera Nucleopolyhedrovirus
... that hydrophobic domains of baculoviral structural proteins, such as AcMNPV ODV-E66 and PIF-3, function as sorting motifs to transport fusion pro- teins to the nucleus and virions (10, ...The hydrophobic ...
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The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A
... 20-amino-acid-long hydrophobic domain, which is flanked on each side by a highly conserved positively charged ...NS5B hydrophobic domain with a domain totally unrelated to NS5B would ...
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cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication.
... Since all the amino acid replacement mutants that introduced charges in the hydrophobic domain of 3AB have a defect in vRNA synthesis, it was of interest to determine whether this defect[r] ...
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Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis.
... a hydrophobic domain with an amino acid composition that is characteristic for transmembrane ...this domain in virus reproduction and to study the structural and hydrophobic requirements of ...
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The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine.
... We show here that the conserved glutamine at position 17 in the hydrophobic domain is also important for transformation and that insertion of the glutamine can rescue the transforming ac[r] ...
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Inactivation of Retroviruses with Preservation of Structural Integrity by Targeting the Hydrophobic Domain of the Viral Envelope
... lipid domain of the viral envelope was selectively targeted to inactivate proteins and lipids therein and block fusion of the virus with the target cell ...the hydrophobic photoinduced alkylating probe 1,5 ...
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Selective Membrane Permeabilization by the Rotavirus VP5* Protein Is Abrogated by Mutations in an Internal Hydrophobic Domain
... basic domain that presumably permits its association with polar head groups of the membrane (11, ...a hydrophobic cleft in the membrane which permits the subunit to enter (2, ...
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Mutations in the E1 Hydrophobic Domain of Rubella Virus Impair Virus Infectivity but Not Virus Assembly
... The sharp increase in G93D virus titer at 3 days posttrans- fection as well as the large-plaque phenotype of G93D virus suggest a selection for revertants of G93D mutation. As a low level of virus was produced in BHK ...
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Degrons at the C Terminus of the Pathogenic but Not the Nonpathogenic Hantavirus G1 Tail Direct Proteasomal Degradation
... the hydrophobic moment of the G1 C-terminal domain regulates proteasomal ...C-terminal hydrophobic domain of pathogenic hantavirus G1 tails appears to define a “degron”-like domain that ...
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The Simian Virus 40 Late Viral Protein VP4 Disrupts the Nuclear Envelope for Viral Release
... membrane disruption. The combined effect of the HD and NLS results in efficient membrane binding. The spatial organization of these domains is highly conserved, and increasing the spacing or changing the topology of this ...
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Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
... the hydrophobic C terminus containing 21 amino acids was removed, yielding a truncated NS5B (NS5B D CT) which is highly soluble and monodispersed in the absence of ...the hydrophobic domain is ...
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Capsid Protein C of Tick-Borne Encephalitis Virus Tolerates Large Internal Deletions and Is a Favorable Target for Attenuation of Virulence
... second hydrophobic element that is present in all flavivirus sequences, approximately in the middle of the primary amino acid sequence ...internal hydrophobic domain, exhibits features reminiscent of ...
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The Longin Domain Regulates the Steady-State Dynamics of Sec22 in Plasmodium falciparum
... longin domain of PfSec22 exhibits signifi- cant differences from yeast and human orthologs, which might influence its cellular locations and trafficking ...longin domain (Fig. 1A) and an N-terminal ...
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Oriented Liquid Crystalline Polymer Semiconductor Films with Large Ordered Domains.
... UV/Ozone will promote silicon dioxide formation on PDMS slab surface and reduce contact angle, but also limit applied strain below 50% since further strain will usually result in crack on PDMS surface. We first transfer ...
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The trans-membrane domain of Bcl-2 a, but not its hydrophobic cleft, is a critical determinant for efficient IP
... 1A). Using genetic and pharmacological approaches, we could however exclude the hydrophobic cleft as a major player in the formation of the Bcl-2α/IP 3 R complex. In contrast, we found that Bcl-2α binding to the ...
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Membrane Integration of Poliovirus 2B Viroporin
... P2 domain is the extramembrane C-terminal domain from the bacterial leader peptidase (Lep) that carries an N-glycosylation site ex- tensively used to report membrane translocation ...
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Lipopolysaccharide is inserted into the outer membrane through an intramembrane hole, a lumen gate, and the lateral opening of LptD
... large hydrophobic lipid A, and hydrophilic oligosaccharide and polysaccharide (O-anti- ...port hydrophobic molecules across the outer ...minal domain are inserted into the outer membrane, forming the ...
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Analysis of Mutationally Altered Forms of the Cct6 Subunit of the Chaperonin From Saccharomyces cerevisiae
... Here, we report the critical hydrophobic residues and clusters of hydrophilic residues in regions corresponding to those from the apical domain of GroEL implicated in peptide b[r] ...
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Low pH-Induced Conformational Change in Herpes Simplex Virus Glycoprotein B
... Enveloped virions are trafficked through cellular compart- ments for up to ⬃ 30 min postinfection (p.i.). Penetration of ⬎ 50% of infectious virions from a low-pH compartment (virus- cell membrane fusion) occurs by 60 ...
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Identification and nucleotide sequence of the glycoprotein gB gene of equine herpesvirus 4.
... The EHV-4 gB protein contains features characteristic of all envelope glycoproteins, namely, a 5' hydrophobic signal sequence, an external hydrophilic surface domain, a hydrophobic membr[r] ...
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