hydroxy-3-methylglutaryl CoA reductase
Identification of a Highly Expressed 3 Hydroxy 3 Methylglutaryl CoA Reductase Gene in the Root Tissue of Taraxacum kok saghyz
... The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the conversion of 3-hydroxy-3-methylglutaryl-CoA to meva- lonic acid, a ...
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Effects of the 3 hydroxy 3 methylglutaryl CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin 1 and endothelial nitric oxide synthase in vascular endothelial cells
... Aside from their inhibitory effects on intracellular choles- terol synthesis (3, 4, 37), statins are able to influence other cel- lular functions such as the regulation of DNA transcription, and both ...
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Control of 3 Hydroxy 3 Methylglutaryl CoA Reductase Activity in Cultured Human Fibroblasts by Very Low Density Lipoproteins of Subjects with Hypertriglyceridemia
... HMG-CoA reductase activity, based on protein content, in agreement with previous reports with normal ...HMG-CoA reductase activity in either normal or Type III ...HMG-CoA ...
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Energy replacement using glucose does not increase postprandial lipemia after moderate intensity exercise
... A number of studies have shown that TG-rich lipo- proteins, chylomicrons and very-low-density lipoproteins (VLDL), can be bound and also directly internalized by cells via the VLDL receptor, a member of the low-density ...
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2. Tingting Tao, Xiaomeng Liu, Jie Chang and Feng Xu
... enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catelyzes the first committed step of isoprenoids biosynthesis in MVA ...
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56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... For the assay of 3-hydroxy-3-methylglutaryl CoA reductase, the incubation mixtures contain 0.5-1.0 mg of microsomal protein, 150 nmoles of HMG- CoA, and 2ìmoles of NADPH. ...
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In vivo regulation of human mononuclear leukocyte 3 hydroxy 3 methylglutaryl coenzyme A reductase Studies in normal subjects
... Finally, reductase activity was inhibited by dichloroacetate, a compound known to lower plasma cholesterol in man and inhibit the human leukocyte enzyme in ...HMG CoA reductase activity in the ...
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Original Article Effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor (HMG-CoA) on the prevention of osteoporosis in ovariectomized rabbits
... Osteoporosis is a chronic, metabolic, and sys- temic skeletal disorder characterized by dimin- ished bone mass, microarchitectural deteriora- tion, predisposing to decrease bone mineral density (BMD) and increase the ...
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Feedback Regulation of 3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase
... reductase. Despite the abundant amount of cholesterol that was already present in the livers of the mevinolin-treated, cholesterol-fed animals, their elevated HMG CoA reductase could be rapidly ...
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Low density lipoprotein receptor and 3 hydroxy 3 methylglutaryl coenzyme A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver
... +/- 3 x 10(4)/micrograms of RNA) and mononuclear leukocytes (24 +/- 3 x 10(4)/micrograms of RNA) are indistinguishable, whereas the number of HMG CoA reductase molecules in liver (107 +/- 15 x ...
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Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3 hydroxy 3 methylglutaryl coenzyme A reductase
... (HMG-CoA) reductase catalyzes the formation of mevalonate, an essential precursor for isoprenoid compounds in mammalian ...the reductase, inhibits cell proliferation and induces differentiation in ...
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Regulation of acylcoenzyme A Cholesterol acyltransferase and 3 hydroxy 3 methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats
... (3- hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase activity) and esterification (acylcoenzyme A/cholesterol acyltransferase [ACAT] activity) by lipoproteins and micellar ...
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3 Hydroxy 3 methylglutaryl coenzyme A reductase in anencephalic and normal human fetal liver
... of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the primary rate- limiting enzyme of cholesterol biosynthesis, in anencephalic liver and normal fetal ...
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INHIBITION OF 3 HYDROXY 3 METHYLGLUTARYL COENZYME A (HMG Co A) REDUCTASE IN LIVER MICROSOMES BY MORINGA OLEIFERA L POLYPHENOLS
... A reductase activity as nMoles of reduced Coenzyme A released at the end of 4 th ...A reductase enzyme than the control group and also it can be observed that there is a significant difference ...HMG ...
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Biologically active low density lipoprotein in human peripheral lymph
... of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), to activate cholesteryl ester synthesis, and to compete with 125I-labeled low density lipoprotein ...
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Clinical and Biochemical Phenotype in 11 Patients With Mevalonic Aciduria
... The site of the defect in patients with mevalonic aciduria is mevalonate kinase (solid square), following 3-hydroxy- 3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate- limiting e[r] ...
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Identification of 3 methylglutarylcarnitine A new diagnostic metabolite of 3 hydroxy 3 methylglutaryl coenzyme A lyase deficiency
... only 3-methylglutaryl-CoA is a substrate for acylcarnitine ...Neither 3-methylglutaconyl-CoA nor 3-hydroxy-3-methylglutaryl- CoA are excreted as ...of ...
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Severe clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report
... chromatographs: 3-hydroxybutyric acid ...and 3-hydroxydicarboxylic acids such as ethylmalonic acid ...0.4–7.0), 3-hydroxysuberic acid (30.66, refer- ence: 0.0–4.8), 3-hydroxysebacic acid ...
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Influence of genotype on the modulation of gene and protein expression by n-3 LC-PUFA in rats
... The response to eicosapentaenoic acid (EPA) ? doco- sahexaenoic acid (DHA) intervention is highly heteroge- neous and supposed to be related to genetic variations; evidence existing on whether the effects of n-3 ...
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Cholesterol lowering effect of mevinolin, an inhibitor of 3 hydroxy 3 methylglutaryl coenzyme a reductase, in healthy volunteers
... Mevinolin reduces cholesterol synthesis by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The safety and effectiveness of this agent was evaluated in a double-blind, ...
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