Hydroxyeicosatetraenoic acid
Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid
... Rhodes, LE, Darby, G, Farrar, MD, Bennett, S, Watson, REB, Massey, KA, Nicolaou, A, Clarke, KA, Dew, TP and Williamson, G (2013) Oral green tea catechin metabolites are incorporated into human skin and protect against UV ...
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Hydroxyeicosatetraenoic acid metabolism in cultured human skin fibroblasts Evidence for peroxisomal beta oxidation
... for hydroxyeicosatetraenoic acid (HETE) oxidation, 12- and 15-HETE oxidation was measured in normal and peroxisomal deficient skin fibroblasts from patients with Zellweger's (cerebrohepatorenal) ...
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Remodeling of neutrophil phospholipids with 15(S) hydroxyeicosatetraenoic acid inhibits leukotriene B4 induced neutrophil migration across endothelium
... 15-Hydroxyeicosatetraenoic acid (15-HETE) is an eicosanoid generated by a variety of cell types via the actions of 15-lipoxygenases and, in addition, cyclooxygenases and ...
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12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition
... 12-hydroxyeicosatetraenoic acid (12-HETE), formed by the enzyme 12-lipoxygenase (12-LOX), is another major platelet-derived eicosanoid, although its role in platelet function remains ...
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Studies on the mechanism of omega hydroxylation of platelet 12 hydroxyeicosatetraenoic acid (12 HETE) by unstimulated neutrophils
... Stimulated platelets, in the presence or absence of aspirin, synthesize significant quantities of 12-hydroxyeicosatetraenoic acid (12-HETE), which is chemotactic and chemokinetic, and enhances mononuclear ...
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New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity
... eicosatetraenoic acid (12- HETE) and 13-hydroxy-9Z,11E octadecadienoic acid (13-HODE) are biologically active compounds derived from the metabolism of arachidonic acid and linoleic acid ...
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Effects of Changes in Oxygen Tension on Vascular and Platelet Hydroxyacid Metabolites II. Hypoxia Increases 15-Hydroxyeicosatetraenoic Acid, a Proangiogenic Metabolite
... some of the initial vascular changes observed fol- lowing hyperoxia, ie, vasoconstriction and throm- bus formation, could be due to inhibition in the production of the potent vasodilator[r] ...
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Differential gene expression mediated by 15 hydroxyeicosatetraenoic acid in LPS stimulated RAW 264 7 cells
... Hz is composed of five-coordinate Fe (III) protoporphyrin IX dimers covalently bound by reciprocal iron-carboxylate bonds [3]. The remaining propionate side chains of adja- cent dimers form hydrogen bonds, resulting in ...
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Enhancement of mononuclear procoagulant activity by platelet 12 hydroxyeicosatetraenoic acid
... Platelets induce generation of procoagulant tissue factor activity (TFa) by mononuclear leukocytes, and also enhance the TFa induced by endotoxin. Our present investigation demonstrated that arachidonic acid, ...
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The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances
... 20- hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor which is formed in vascular smooth muscle cells (VSMC) by the CYP450-4A enzyme system [40, 41, 43, ...
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Interferon gamma induces the synthesis and activation of cytosolic phospholipase A2
... Both IFN-alpha/beta and IFN-gamma have recently been demonstrated to induce a rapid but transient activation of phospholipase A2 (PLA2) in BALB/c 3T3 fibroblasts and a human neuroblastoma cell line. We report that ...
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Formation of carboxylic acids during degradation of monosaccharides
... The formation of low molecular carboxylic and hydroxycarboxylic acids as well as sugar and deoxysugar acids from monosaccharides (d-glucose, d-fructose, d-arabinose, dl-glyceraldehyde, and 1,3-dihydroxyacetone) was ...
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... palimitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha linoleic acid, arachidic acid, eicosanoic acid, behenic acid, and erucic ...
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In Vitro Metabolite Colonic Production from Otili (Sphenostylis stenocarpa) as Influenced by Selected Gastrointestinal Microbes
... 2.5. Gas Chromatography-Mass Spectrometry (Gc-Ms) Analysis The volatile constituents were analyzed with an Agilent 5975C VL mass selective detector coupled to an Agilent 7890A gas chromatograph (Agilent Technologies, ...
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Journal of Applied Pharmaceutical Science
... Chlorogenic acid is a natural dietary flavanone which has been identified in different species of ...Chlorogenic acid has been recognized as a potent antioxidant, antinflammatory and anticarcinogenic ...
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Natural Antioxidant Changes in Fresh and Dried celery (Apium graveolens)
... chlorogenic acid, syringic acid, caffeine , p- coumaric acid, ferulic acid, salycilic acid, cinnamic acid, chrysin, pyrogallol , ellagic acid , catechin and caffeic ...
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ANTIBACTERIAL ACTIVITY AND GCMS ANALYSIS OF THE EXTRACT OF LEAVES OF RHIZOPHORA APICULATA (A MANGROVE PLANT)
... Ursolic acid was reported to be cytotoxic against A- 549, L-1210 and KB tumour cells (Yamagishi et ...oic acid was found to exhibit anti-ulcer properties (Fourie et ...palmitic acid as major ...
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Gas Chromatography-Mass Spectrometry Analysis of the Anti-MRSA Fractions of Chromolaena odorata (L.) R.M. King & H. Rob. leaves
... identified in the eight fractions in this study) and decanoic acid (identified in five fractions) (Table 2). In this study, it appears that the major chemical compounds responsible for the anti-MRSA activity of C. ...
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Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action
... phenolic acid was found, with IC 50 values varying from the nanomolar to the picomolar ...caffeic acid exerts its action later than other phenolic acids, suggesting a different mode of ...Ferulic ...
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A study of the fatty acid profile in the muscle of Monopterus chuchia
... esters (FAME) mixture obtained was analyzed using a Shimadzu Gas Chromatograph (Model: GC-2010, Shimadzu, Japan) with a Flame ionization detector (FID) on a split injector. A SP-2560 capillary column (100 m long x 0.25 ...
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