Hydroxysteroid dehydrogenase
Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: Effect of the deciduoma reaction
... 20alpha-hydroxysteroid dehydrogenase (20alphaHSD), the enzyme that catabolizes progesterone giving rise to a metabolite without progestational capabil- ity, and, therefore, incapable of supporting ...
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Regulation of 11β Hydroxysteroid Dehydrogenase Type 1 and 2 in Rheumatoid Arthritis
... 11β-hydroxysteroid dehydrogenase enzymes type 1 and 2 have not been in- vestigated so far in patients suffering from rheumatoid arthritis before and after starting treatment though the enzymes balancing ...
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11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
... -Hydroxysteroid dehydrogenase type 1 (11 -HSD1) is a bidirectional GC-activating enzyme that is potently upregulated by inflammation within mesenchymal-derived ...
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Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells
... In the male, the Leydig cell, in the interstitium of testis, is the primary source of sexual steroid hormone testoster- one, which stimulates differentiation of the male pheno- type and spermatogenesis in the testes. ...
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Immunoexpression of aromatase cytochrome P450 and 17β-hydroxysteroid dehydrogenase in women’s ovaries after menopause
... Methods: This study was performed on 104 postmenopausal women hospitalized due to uterine leiomyomas, endometriosis, and/or a prolapsed uterus. Patients were divided into three groups depending on the time from ...
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Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C elegans, and mammals
... Lipid droplets (LDs) are the main fat storing sites in almost all species from bacteria to humans. The perilipin family has been found as LD proteins in mammals, Drosophila, and a couple of slime molds, but no bacterial ...
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11β Hydroxysteroid dehydrogenase blockade prevents age induced skin structure and function defects
... We hypothesize that with no appreciable changes in circulating cortisol concentrations with age, changes in tissue-specific prere- ceptor regulation of local GC availability by 11 β-hydroxysteroid ...
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QSAR Studies on Keto Sulfones Derivatives as Inhibitors of 11β Hydroxysteroid Dehydrogenase Type 1
... 11β-hydroxysteroid dehydrogenase type 1 is a key enzyme that acts as an NADPH-dependent reductase capable of converting the inactive 11β- glucocorticoids such as cortisone into their active form, ...
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Ontogeny of adrenal like glucocorticoid synthesis pathway and of 20α hydroxysteroid dehydrogenase in the mouse lung
... -hydroxysteroid dehydrogenase/ Δ 5 - Δ 4 isomerase 1 (3 β -HSD1), 21-hydroxylase, 11 β -hydroxylase, 11 β -HSD1, and 11 β -HSD2 expression up to post natal day (PN) ...
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The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
... activates and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids. It was reported that the expression of 11β-HSD1 was increased in adipo- cytes, especially in visceral fat, of ...
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3 alpha hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol Identification, kinetics, and physiologic significance
... Since the enzyme can bind bile acids at the active site without biotransformation, 3a-hydroxysteroid dehydrogenase activity might be regulated by bile acid flux through the liver, and th[r] ...
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Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
... 11b-hydroxysteroid dehydrogenase type 1 ...alcohol dehydrogenase, localised in the lumen of the endoplasmic reticulum, that interconverts active ...
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Hypertension in mice lacking 11β hydroxysteroid dehydrogenase type 2
... Targeted inactivation of 11β-HSD2 gene. (a) Structure of the targeting vec- tor, the 11β-HSD2 locus, and the targeted allele. (b) Southern blot hybridization analysis of XbaI-digested genomic DNA from neomycin- resistant ...
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Epigenetic regulation of 11β hydroxysteroid dehydrogenase type 2 expression
... 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) is selectively expressed in aldosterone target tissues, where it confers aldosterone selectivity for the mineralocorticoid receptor by inactivating ...
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THE ADRENOGENITAL SYNDROME WITH DEFICIENCY OF 3β HYDROXYSTEROID DEHYDROGENASE
... In those cases attributed to a deficiency of 3,8-hydroxysteroid dehydrogenase I-VI, the largest part of the steroids isolated and identified was comprised of compounds with A5-3,8-ol str[r] ...
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Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: An hypothesis
... In mouse ovaries, the enzyme 3 beta-hydroxysteroid dehydrogenase (HSD) is distributed between microsomes and mitochondria. Throughout the follicular phase of the estrous cycle, the HSD activity in ...
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Distribution of 11 beta hydroxysteroid dehydrogenase along the rabbit nephron
... It has been recently proposed that 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is responsible for aldosterone tissue specificity. A 11 beta-OHSD deficiency has been invoked as a cause of the ...
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Reduced activity of 11β hydroxysteroid dehydrogenase in patients with cholestasis
... Enhanced renal sodium retention and potassium loss in patients with cirrhosis is due to activation of mineralocorticoid receptors (MRs). Increased aldosterone concentrations, however, do not entire- ly explain the ...
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11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
... In study subjects < 35 years of age, 11 β HSD1 activity was significantly increased in diabetics as compared to healthy controls (Table 4 , Fig.. In other age groups, 11 β HSD1 activi[r] ...
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Morphology-Specific Inhibition of β-Amyloid Aggregates by 17β-Hydroxysteroid Dehydrogenase Type 10
... amyloid-binding alcohol dehydrogenase (ABAD)) [21,23 26] constitutes one of such mitochondrial A- interacting proteins. [6,27] 17-HSD10 is a 27 kDa multifunctional enzyme expressed in all cell types and is ...
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