-Hydroxysteroid Dehydrogenase Type 1
Expression of gluconeogenic enzymes and 11β-hydroxysteroid dehydrogenase type 1 in liver of diabetic mice after acute exercise
... of type 2 diabetes is poorly ...11β-hydroxysteroid dehydrogenase type 1 was increased significantly in db/db mice compared to lean mice after ...11β-hydroxysteroid ...
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The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
... -hydroxysteroid dehydrogenase type 1 (11 β -HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases ...
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Saturated fatty acids in human visceral adipose tissue are associated with increased 11- β-hydroxysteroid-dehydrogenase type 1 expression
... Cortisol has a major impact on body fat accumulation. VAT has a higher concentration of glucocorticoid receptors than SAT [4], and lipoprotein lipase activity is increased by cortisol with depot specific differences [7]. ...
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A novel genetically-obese rat model with elevated 11beta-hydroxysteroid dehydrogenase type 1 activity in subcutaneous adipose tissue
... 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) catalyzes the conversion of inactive glucocorticoids to active glucocorticoids and plays an important role in the development of obesity and ...
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Crystal Structures of Human 17β Hydroxysteroid Dehydrogenase Type 1 Complexed with the Dual Site Inhibitor EM 139
... Seventeen β -hydroxysteroid dehydrogenase type 1 (17 β -HSD1, EC. 1.1.1.62) cat- alyzes the NAD(P)H dependent conversion of estrone (E1) to the most potent estrogen, 17 β -estradiol (E2) ...
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Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue
... 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) plays an important role in the development of obesity and insulin resistance. 11b-HSD1 reactivates inactive glucocor- ticoids ...
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QSAR Studies on Keto Sulfones Derivatives as Inhibitors of 11β Hydroxysteroid Dehydrogenase Type 1
... 11β-hydroxysteroid dehydrogenase type 1 is a key enzyme that acts as an NADPH-dependent reductase capable of converting the inactive 11β- glucocorticoids such as cortisone into their active ...
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Increased Expression of 11β Hydroxysteroid Dehydrogenase Type 1 in Experimental Periodontitis Induced by Lipopolysaccharide from Porphyromonas gingivalis
... -hydroxysteroid dehydrogenase type 1 (11 β - HSD1), which activates glucocorticoids, plays a role in chronic inflammatory diseases including metabolic diseases, rheumatoid arthritis, and ...
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11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
... -Hydroxysteroid dehydrogenase type 1 (11 -HSD1) is a bidirectional GC-activating enzyme that is potently upregulated by inflammation within mesenchymal-derived ...
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11β Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells
... Purpose: Glucocorticoids, stress-related hormones, inhibit hair growth. Intracellular glucocorticoid availability is regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD1 ...
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17beta hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration
... inhibitor 1; RP: reversed-phase; RT- PCR: reverse transcription polymerase chain reaction; RT-qPCR: reverse transcription quantitative real-time polymerase chain reaction; SDS-PAGE: sodium dodecyl ...
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Differential expression, function and response to inflammatory stimuli of 11β hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue specific regulation of inflammation
... oid dehydrogenase type 1 (11β-HSD1), which is located on the luminal surface of the endoplasmic reticulum ...and dehydrogenase (that is, cortisol to corti- sone) ...hexose-6-phosphate ...
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Regulation of 11β Hydroxysteroid Dehydrogenase Type 1 and 2 in Rheumatoid Arthritis
... diol, stigmasterol, cholesteryl butyrate, and 3β5β-tetra- hydroaldosterone added as internal standards. Samples were derivatised to form methyloxime-trimethylsilyl ethers. After adding 100 µl of methoxyamine HCl in ...
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An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells
... These results seem to suggest that 11β-HSD1 inhibition is a potential therapeutic target for treating metabolic syn- dromes. In this study, we explore whether PF915275 (PF; 4′-cyano-biphenyl-4-sulfonic acid ...
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Intratumoral localization and activity of 17β hydroxysteroid dehydrogenase type 1 in non small cell lung cancer: a potent prognostic factor
... It is also true that 17βHSD1 and 17βHSD2 immunoreac- tivity was very heterogeneous in NSCLC cases (Figure 1). Therefore, based on relative immunointensity of either 17βHSD1 and/or 2 in cytoplasm of the tumor ...
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Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
... oid dehydrogenase type 1 (11β-HSD1), which is located on the luminal surface of the endoplasmic reticulum ...and dehydrogenase (that is, cortisol to corti- sone) ...hexose-6-phosphate ...
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Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue
... 11b-Hydroxysteroid dehydrogenase type 1 (11b-HSD1) and we have hypothesized that 11b-HSD1 activity can regulate lipid homeostasis in human adipose tissue (Chub-S7 cell line and primary ...
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Uncovering steroidopathy in women with autism: a latent class analysis
... CYP17A1 is overexpressed in theca cells of women with PCOS [25], and its overexpression is driven by increased insulin receptor signaling, [26] such that hyperinsulinemia can eventually cause hyperandrogenemia [27]. ...
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Complexities of gender assignment in 17β-hydroxysteroid dehydrogenase type 3 deficiency: is there a role for early orchiectomy?
... Patient A was a Caucasian female who presented to our center in early childhood. She was born with female ex- ternal genitalia. When she was 16 months old, she underwent elective surgery for repair of umbilical and ...
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Morphology-Specific Inhibition of β-Amyloid Aggregates by 17β-Hydroxysteroid Dehydrogenase Type 10
... take place at a rate that competes with the relatively fast average aggregation rate reported for the globular aggregate (< 2 min -1 ). [34] It has been shown previously that freshly prepared HFIP-induced ...
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