HYPERPARATHYROIDISM AND HYPERCALCEMIA
Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism Effects of mutant gene dosage on phenotype
... severe hyperparathyroidism is a rare life-threatening disorder characterized by very high serum calcium concentrations (> 15 ...hypocalciuric hypercalcemia, a benign condition transmitted as a dominant ...
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Primary Hyperparathyroidism with Severe Hypercalcemia in Pregnancy Complicated by Acute Pancreatitis; A Rare Case Report And Literature Review
... Results: A 36-year-old multigravida Saudi woman presented during her 34th week of gestation with a five days history of epigastric pain, nausea and vomiting.Diagnosis was made as Primary hyperparathyroidism with ...
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Functional Parathyroid Cyst: A Rare Cause of Malignant Hypercalcemia with Primary Hyperparathyroidism—A Case Report and Review of the Literature
... Copyright © 2012 Areej Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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THE SEPARATE EFFECTS OF HYPERPARATHYROIDISM, HYPERCALCEMIA OF MALIGNANCY, RENAL FAILURE, AND ACIDOSIS ON THE STATE OF CALCIUM, PHOSPHATE, AND OTHER IONS IN PLASMA
... Plasma from patients with primary and sec- ondary hyperparathyroidism, hypercalcemia of malignancy, vitamin D intoxication, and primary renal failure, with and without acidosis, has been[r] ...
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Primary Hyperparathyroidism Manifesting with Severe Hypercalcemia in a Nonagenarian Man: Pitfall of Common Imaging Techniques, Localization by 18F-Choline Positron Emission Tomography/Computed Tomography and Successful Management with Calcimimetics
... A nonagenarian hypertensive man with chronic kidney disease (CKD) was admitted to the emergency department for gastrointestinal symptoms and worsening symptoms of depression. Severe hypercalcemia (15.3 mg/dL) was ...
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Serum bone gamma carboxyglutamic acid containing protein in primary hyperparathyroidism and in malignant hypercalcemia Comparison with bone histomorphometry
... Serum bone y-carboxyglutamic acid-containing (Gla) protein (sBGP), a sensitive and specific marker of bone turnover, was measured in 25 patients with primary hyperparathyroidism and in 2[r] ...
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In vivo and in vitro characterization of neonatal hyperparathyroidism resulting from a de novo, heterozygous mutation in the Ca2+ sensing receptor gene: normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hypocalciuric hypercalcemia
... severe hypercalcemia and secondary hyper- parathyroidism in this case, relative to other cases in which a child with FBHH is born to a normal mother, most likely re- lates to the dominant negative effect of this ...
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Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism
... of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism Serra, Andreas L ; Schwarz, Albin A ; Wick, Franziska H ; Marti, Hans-Peter ; Wüthrich, Rudolf P Abstract: ...
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Calcium sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
... conformational polymorphism identification of CaR mutations may help in the distinction of FBH from mild primary hyperparathyroidism which can be clinically difficult. Thus, the results of our study will help to ...
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Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism
... Andreas L. Serra, Albin A. Schwarz, Franziska H. Wick, Hans-Peter Marti and Rudolf P. Wu¨thrich Division of Nephrology, University Hospital, Ra¨mistrasse 100, 8091 Zu¨rich, Switzerland Abstract Background. Cinacalcet ...
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Hypercalcemia is a disorder
... mary hyperparathyroidism, the leading cause of ...of hypercalcemia are distinguishing primary hyperparathyroidism from condi- tions that will not respond to parathyroidec- tomy and knowing when it is ...
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Management of hypercalcemia of malignancy
... severe/acute hypercalcemia leads to severe mental impairment, renal failure, and life-threatening medical ...of hypercalcemia vary in the level of calcium in the blood, and the severity of ...
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Markedly reduced activity of mutant calcium sensing receptor with an inserted Alu element from a kindred with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
... All of the mutations that have been examined to date, how- ever, cause single putative amino acid substitutions. In this report, we studied a mutant CASR with an Alu-repetitive element inserted at codon 876, which was ...
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Primary hyperparathyroidism
... Primary hyperparathyroidism is also associated with rare familial disorders, including multiple endo- crine neoplasia (MEN) type 1 and type 2A syndromes, familial hypocalciuric hypercalcemia (FHH), familial ...
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Asymptomatic Neonatal Familial Hypercalcemia
... In the context of subsequently well docu- mented familial hypocalciuric hypercalcemia, Spie- gel et al’4 and Marx et al2’ described an infant with severe neonatal hyperparathyroidism in [r] ...
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Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer
... primary hyperparathyroidism could be excluded as a cause of the hypercalcemia in 16 of the 18 patients with ectopic ...ectopic hyperparathyroidism is immunologically different from the PTH in the ...
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Skeletal Manifestations of Hyperparathyroidism
... of hyperparathyroidism are due to increased bone catabolism and hypercalcemia as nephro- lithiasis, renal failure, peptic ulcer, and mental changes ...
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Familial isolated hyperparathyroidism
... isolated hyperparathyroidism (FIHP) has been greatly facilitated in recent years by the iden- tification of the genes responsible for most cases of syn- dromic familial hyperparathyroidism ...isolated ...
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An unusual case of malignancy-related hypercalcemia
... The benefit of cinacalcet may extend beyond the calcium lowering effects. The CaSR is known to be expressed in a number of tissues not classically considered to play a role in calcium regulation. 35 Recent studies have ...
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Clinical impact of hypercalcemia in kidney transplant
... posttransplant hyperparathyroidism (PT-HPT) of moderate-severe degree is universally considered the first causal ...secondary hyperparathyroidism (SHP) during the uraemic ...
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