Hypertrophic chondrocyte
Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9
... of hypertrophic chondrocytes is a tightly regulated process that plays a pivotal role in endochondral ...of hypertrophic chondrocytes by repressing ...by hypertrophic chondrocytes from late embryonic ...
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SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice
... Several studies have reported that SIK1 and SIK2 directly regulate HDACs (van der Linden et al., 2007; Takemori et al., 2009). Fly SIK3 (the homolog of mouse SIK2) has recently been shown to sequester HDAC4 in the ...
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Transglutaminase 2 in cartilage homoeostasis: novel links with inflammatory osteoarthritis.
... arthritis severity in mice (Raghu et al. 2015). TG2 could also be involved as cystamine displays high specificity towards inhibiting TG2 transamination activity (Siegel and Khosla 2007). Future studies should, therefore, ...
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Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing
... in hypertrophic chondrocyte ...postnatal hypertrophic chondrocytes in the growth plate, with very high SULF2 expression compared with SULF1 apparent during neonatal growth in both primary and ...
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Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
... mature hypertrophic chondrocytes undergo apoptosis. The hypertrophic chondrocytes secrete vascular endothelia growth factor (Vegf) and matrix metalloproteinases (Mmps), which will degrade the extracellular ...
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Accelerated endochondral growth in adolescents with idiopathic scoliosis: a preliminary histomorphometric study
... of hypertrophic chondrocytes was demonstrated by Breur et ...and hypertrophic chondrocytes ...and hypertrophic chondrocytes in the anterior spinal col- umn of IS patients were more active than those ...
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Effects of 5 Aza 2’ Deoxycytidine on Proliferation and Differentiation of Embryonic Chick Caudal Region Chondrocytes in Culture
... into hypertrophic chondrocytes as described above. These hypertrophic cells secrete type X collagen and alkaline phosphatase enzyme [8, 9] as well as different cartilage degrading proteases which results in ...
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Specification of chondrocytes and cartilage tissues from embryonic stem cells
... In summary, the findings presented here have established the developmental program for chondrogenic mesoderm formation from mESCs and have identified regulatory pathways that play a role in the specification of this ...
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Wnt/β catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
... the hypertrophic cartilaginous region to replace it with trabecular ...bone. Chondrocyte hypertrophy is required for ossification because hypertrophic chondrocytes secrete factors such as Indian ...
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Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription
... Mature hypertrophic chondrocytes eventually die, allowing vascular invasion, a process that involves the entry of osteoclast and osteoblast ...on chondrocyte proliferation and differentiation and is ...
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Midventricular Obstructive Hypertrophic Cardiomyopathy during Pregnancy Complicated by Pulmonary Embolism: A Case Report
... obstructive hypertrophic cardiomyopathy is uncertain, difficult, and complicated by high incidences of fatal ventricular arrhythmias and sudden cardiac death ...obstructive hypertrophic cardiomyopathy and ...
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Response of human chondrocytes and mesenchymal stromal cells to a decellularized human dermis
... with Chondrocyte Differen- tiation Medium (CDM, containing fetal bovine serum 5%, gentamycin sulphate-amphotericin B ...Complete Chondrocyte Induction Medium (Lonza Walkersville ...
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Detecting cathepsin activity in human osteoarthritis via activity based probes
... GB123 was pre-incubated with chondrocyte extracts, which were stimulated or unstimulated with TNFα and IL1β. A more than four-fold increase in cathepsin S ac- tivity was detected (25-kDa band), without detectable ...
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Gel type autologous chondrocyte (Chondron™) implantation for treatment of articular cartilage defects of the knee
... The number of cells introduced in initial explants is important as the seeded chondrocyte number is linearly related to biosynthetic activity [16]. In that respect, GACI can have an advantage over other treatments ...
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Hypertrophic stimuli induce transforming growth factor beta 1 expression in rat ventricular myocytes
... Transforming growth factor-beta 1 (TGF-beta 1) is a peptide growth factor that may play a role in the myocardial response to hypertrophic stimuli. However, the cellular distribution, mechanism of induction, and ...
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Sulfate Metabolism in Human Chondrocyte Cultures
... Since previous studies from these laboratories had shown that sulfated proteoglycan metabolism in chondrocyte cultures was strongly influenced by environmental pH, and particularly that [r] ...
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Original Article Role of thrombospondin-4 in fibroblasts from normal skin and hypertrophic scars
... Superficial hypertrophic scars on the body may present symptoms including pain and itching, and these may also affect ...Furthermore, hypertrophic scars that form in organs ...
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Experimental Study of 5 fluorouracil Encapsulated Ethosomes Combined with CO2 Fractional Laser to Treat Hypertrophic Scar
... Human hypertrophic scar tissue was analyzed by con- focal laser scanning microscopy (CLSM) at 10 μm incre- ments. Fluorescence intensity was analyzed using a Laser Scanning Microscope LSM 510 (Zeiss, Jena, ...
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Regulation of chondrogenesis and chondrocyte differentiation by stress
... Effects of stress on chondrogenesis and endochondral ossification during normal skeletal development and maintenance Within the framework of the processes of chondrogenesis and chondrocy[r] ...
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Infantile Hypertrophic Pyloric Stenosis A Rarity in Malaysia?
... Infantile Hypertrophic Pyloric Stenosis A Rarity in Malaysia? Med J Malaysia Vol 37 No 4 December 1982 INFANTILE HYPERTROPHIC PYLORIC STENOSIS A RARITY IN MALAYSIA? A ZULKIFLEE LAlDIN RUBAIYAT PROEHOE[.] ...
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