Hypertrophic chondrocytes
Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9
... differentiated hypertrophic chondrocytes actively express genes that allow the invasion of blood vessels, osteoclasts and osteoblast precursors from the perichondrium, suggesting additional regulatory ...
9
MicroRNA-27b targets CBFB to inhibit differentiation of human bone marrow mesenchymal stem cells into hypertrophic chondrocytes
... normal chondrocytes, miR-27b has been re- ported as a key regulatory factor in chondrocyte development and differentiation ...cartilage, chondrocytes in the superficial zone of articular cartilage had ...
17
Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis
... OA chondrocytes includes those related to lipid metabolism, prostaglandin synthesis, glutathione metabolism and metabolism through the cytochrome p450 (Table ...
16
Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes
... that chondrocytes regain multipotency, we do show that activation of pluripotency programs has a functional role during fracture healing and propose that this allows for epigenetic remodeling to switch off ...
14
Increased intracellular proteolysis reduces disease severity in an ER stress–associated dwarfism
... the hypertrophic zone (Figure 3A), accompa- nied by a sporadic reexpression of collagen II mRNA (Figure ...the hypertrophic zone (Figure 3, A and ...terminal hypertrophic chondrocytes ...
6
The cn/cn dwarf mouse Histomorphometric, ultrastructural, and radiographic study in mutants corresponding to human acromesomelic dysplasia Maroteaux type (AMDM)
... the hypertrophic zone even though the num- ber of hypertrophic chondrocytes is less and the zone is markedly ...and hypertrophic chondrocytes which appeared to increase with age but ...
12
Transglutaminase 2 in cartilage homoeostasis: novel links with inflammatory osteoarthritis.
... arthritis severity in mice (Raghu et al. 2015). TG2 could also be involved as cystamine displays high specificity towards inhibiting TG2 transamination activity (Siegel and Khosla 2007). Future studies should, therefore, ...
9
Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing
... in hypertrophic chondrocyte ...articular chondrocytes but down- regulated in a larger subset of cells in the postnatal articular ...articular chondrocytes, SULF1/SULF2 expression varied markedly in ...
23
Effect of nitrogen-rich cell culture surfaces on type X collagen expression by bovine growth plate chondrocytes
... plate chondrocytes expressing the hyper- trophic phenotype (cells that express type X collagen) on PPE:N, Primaria ® , or regular polystyrene (PS) culture dishes was investigated using reverse transcriptase (RT) ...
12
Accelerated endochondral growth in adolescents with idiopathic scoliosis: a preliminary histomorphometric study
... of hypertrophic chondrocytes was demonstrated by Breur et ...and hypertrophic chondrocytes ...and hypertrophic chondrocytes in the anterior spinal col- umn of IS patients were ...
8
Specification of chondrocytes and cartilage tissues from embryonic stem cells
... and hypertrophic chondrocyte-enriched populations and respective cartilage-like tissues had been generated in vitro, grafts were ossified when subcutaneously transplanted in ...the hypertrophic ...
14
Phosphorylation of GSK 3β by cGMP dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
... and hypertrophic zones with accumulation of few proliferative or hypertrophic chondrocytes, which indicates that the kinase activity of cGKII is necessary for ...
11
Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes
... natural hypertrophic cartilage is essential to allow of mineralisation and bone remodelling in ...of hypertrophic cartilage was successful in vitro on the PGA scaffold material, these constructs failed to ...
42
SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice
... of chondrocytes in the sternum, ribs and spine, and impaired skull bone formation in SIK3-deficient ...proliferative chondrocytes occupied the inside of the ...and hypertrophic chondrocytes in ...
11
The AP1 transcription factor Fra2 is required for efficient cartilage development
... into chondrocytes. Chondrocytes first proliferate, then differentiate into prehypertrophic chondrocytes and eventually become hypertrophic chondrocytes, thus forming the typical ...
9
Hypertrophic stimuli induce transforming growth factor beta 1 expression in rat ventricular myocytes
... Transforming growth factor-beta 1 (TGF-beta 1) is a peptide growth factor that may play a role in the myocardial response to hypertrophic stimuli. However, the cellular distribution, mechanism of induction, and ...
8
Original Article Effects of allicin on the proliferation and cell cycle of chondrocytes
... the chondrocytes to allicin at a concen- tration of 40 µM significantly promoted the cell ...of chondrocytes by promoting the transition from G1 to S phase of the cell cycle through increase in the ...
8
Midventricular Obstructive Hypertrophic Cardiomyopathy during Pregnancy Complicated by Pulmonary Embolism: A Case Report
... obstructive hypertrophic cardiomyopathy is uncertain, difficult, and complicated by high incidences of fatal ventricular arrhythmias and sudden cardiac death ...obstructive hypertrophic cardiomyopathy and ...
5
Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes
... that chondrocytes, regardless of pathology, exhibit extensive control over the turnover of a selection of expressed ...how chondrocytes regulate genes in response to changes in their environ- ...
10
P< 0.05). Also, the group D had lower cell proportion and cell apoptosis rate than the
... each hole at a six-well plate, the cells were divided into four groups: miR-145 mimic group, miR-145 inhibitor group, negative control group (sequence-unrelated) and blank group. Each group had 3 auxiliary holes. Then ...
7