hypoxia-inducible factor-1 α
Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
... growth factor (PDGF)-BB ...stabilizes hypoxia inducible factor (HIF)-1a, a transcription factor critical for regulation of important proliferative and vaso-active mediators [29-31], we ...
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Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α
... hence hypoxia on its own was the stimulus of ...that hypoxia-induced PH in rats is more severe in males than females and we wished to determine the effects of 2ME2 on these in vivo sex-dependent ...
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Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma
... carcinoma. Hypoxia inducible factor-1 α (HIF-1 α ) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene ...
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Endothelial cell pseudopods and angiogenesis of breast cancer tumors
... of hypoxia inducible factor 1- α (HIF) reveals the subcortical area of the tumor to contain HIF positive cells while the tumor capsule, cortex and necrotic areas of the tumor ...
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Macrophages: friend or foe in idiopathic pulmonary fibrosis?
... that hypoxia-inducible factor 1-α (HIF-1α) enhances ADORA2B expression to regulates M2 macrophage differ- entiation and production of profibrotic mediators ...
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Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes
... of 1 μ ...for 1 hour at room temperature and then incubated with primary antibodies against HIF-1 α (1:1,000) over- night at 4 ° ...HIF-1 α protein was detected by goat ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... anti-hypoxia-inducible factor (HIF)-1 α antibody (Santa Cruz Biotechnology), anti- HIF-1 β antibody (Cell Signaling Technology Inc, Danvers, MA), anti-VEGF antibody (Santa Cruz ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... H: hypoxia; HACE: high-altitude cerebral edema; HIF-1 α : hypoxia-inducible factor 1 alpha; Hg: mercury; HRP: horse radish peroxidases; ICAM: intercellular adhesion ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... HIF-1 α is inherently expressed in AI-resistant cells, upregulated by HER2-PI3K/Akt-mTOR pathway and is an important factor in letrozole-resistant breast cancer cells, regulating target genes such as ...
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Hypoxia Regulation of NFκB signalling during inflammation: the role of hydroxylases
... by hypoxia in a number of studies [12,18,19]. Cyclooxygenase 2 [20], TNF α [21], IL-6 [22] and macrophage inflammatory protein 2 [23] are among the target genes identified for hypoxia-induced NF κ B, ...
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Emerging evidence of the physiological role of hypoxia in mammary development and lactation
... During hypoxia, tissues undergo a series of physiological responses to defend themselves against a low oxygen supply, including increased angiogenesis, erythropoiesis, and glucose ...of hypoxia are mainly ...
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Prognostic value of factors associated with hypoxia and lipid metabolism in patients with colorectal cancer
... LXRs are nuclear hormone receptors that regulate the metabolism of cholesterol and fatty acids as well as the in- nate immune response, wherein they modulate the release of IL (interleukin) and TNF (tumor necrosis ...
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Type H blood vessels in bone modeling and remodeling
... 14]. Hypoxia-inducible factor 1 alpha (HIF-1α), Notch, and VEGF signaling, which are well known factors in the vascular field that induce EC proliferation, migration, and vessel formation, are ...
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PubMedCentral-PMC5138100.pdf
... On the other hand, in the presence of hypoxia or potentially PHD1 depletion, DYRK1A and DYRK1B cannot be efficiently hydroxylated or phosphorylated. Therefore, ID2 is not phosphorylated on Thr27, which ...
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Telomeres are elongated in rats exposed to moderate altitude
... moderate hypoxia were good and without significant oxidative ...severe hypoxia (low oxygen tension) can damage cellular components by producing ROS through the oxidation of DNA, proteins and ...
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Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment
... The kidney tissue was homogenized in ice cold lysis buf- fer (containing 150 mM NaCl, 50 mM Tris–HCl (pH 7.5), 1 mM DTT, 50 mM NaF, 1 mM PMSF, 1 mM EDTA, 1 mM EGTA, 0.1 mM orthovanadate, 0.05% ...
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The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation
... after transplantation and, ultimately, the outcomes of the grafts [9, 12, 13, 24]. Our team expects that although HIF-1α, VEGF-A, and other proteins were up in the early stage of transplantation, their influence was per- ...
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Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer
... Core needle biopsy specimens were fixed in 10 % buffered formalin and embedded in paraffin; 4 μm-thick sections were cut from each block and stained with hematoxylin and eosin. Tumor pattern and score was established ac- ...
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The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
... (type 1 helper T cells) cytokine profile and stimulated proliferation of IFN-γ (interferon-γ) producing T cells ...stimulating factor, M-CSF) skewed macrophage polarization towards a pro-inflammatory ...
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