Hypoxia-Inducible Factor-1 Alpha
Original Article mRNA expression level and clinical value of hypoxia inducible factor 1 alpha in patients with myelodysplastic syndromes: a fluorescence quantitative real-time RT-PCR study
... Abstract: Objective: The clinical value and prospective function of hypoxia inducible factor 1 alpha (HIF-1α) in my- elodysplastic syndromes (MDS) remain poorly understood. Therefore, ...
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Hypoxia-inducible factor 1 alpha expression is an indicator of invasiveness in uterine cervical tumors
... distilled water, then treated with decreasing concentrations of alcohol. All slides were subjected to heat- induced epitope retrieval procedure in the microwave (in 10mM/L citrate buffer, pH 6.0, for minutes, followed by ...
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Original Article LDHA is a feedback activator of hypoxia inducible factor 1-alpha in ovarian cancer
... Abstract: Hypoxia inducible factor 1-alpha (HIF-1α) is commonly up-regulated in multiple human malignancies, and plays an important role in tumor metabolism through regulating ...
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Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma: a meta-analysis
... August 1, 2015, and no lower date limit was ...“HIF-1 alpha” or “hypoxia-inducible factor-1 α ” or “hypoxia-inducible factor-1 ...
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Modeling the dynamics of hypoxia inducible factor-1 alpha (HIF-1 alpha) within single cells and 3D cell culture systems
... In Fig 7, we model a tumorsphere that experiences an acute hypoxic switch from 20 % oxygen to hypoxia (1 %). As in Fig 6, we present results from the coupled numerical solution of the extended HIF-1α ...
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Hypoxia inducible factor 1 alpha in high risk breast cancer: an independent prognostic parameter?
... An increasing body of evidence indicates that hif-1α expression is inversely correlated with tumor control and/or patient survival. This has been demonstrated to date for oligodendroglioma [18] and for a broad range of ...
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A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers
... Hypoxia inducible factor 1α (HIF1A), is a transcription factor that has major impacts in the process of develop- ment and progression of cancers ...
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Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer
... Then, 1 μ L cDNA from each sample was used as template to perform PCR reaction in a 20 μ L system with primers for HIF-1 α , MDR1, GLUT1 (glucose transporter 1), and ...
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Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells
... We also discovered that HIF-MSCs produce higher levels of the chemokine CCL2/MCP1 under inflamma- tory conditions, showing as well a tendency to promote greater attraction of monocytes. This is in agreement with recent ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... incubated overnight at 4°C, the incubation time for HIF-1α and CAIX was 30 min at room temperature, and CD31 was incu- bated for 1 hour at room temperature. VEGF, Ki67 and p53 were detected by application of a ...
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Type H blood vessels in bone modeling and remodeling
... 14]. Hypoxia-inducible factor 1 alpha (HIF-1α), Notch, and VEGF signaling, which are well known factors in the vascular field that induce EC proliferation, migration, and vessel ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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... intermittent hypoxia in OSAHS identified two molecular pathways: A nuclear factor-κB (NF-κB)-dependent inflammatory pathway, which produces inflammatory cytokines, and hypoxia-in- ducible ...
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Original Article Profilin-1 mediates microvascular endothelial dysfunction in diabetic retinopathy through HIF-1α-dependent pathway
... and hypoxia inducible factor-1 alpha (HIF-1α) in cultured human retinal microvascular endothelial cells (HRMECs) treated with high glucose and in 6 month-old Sprague-Dawley (SD) rats ...
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Prognostic value of factors associated with hypoxia and lipid metabolism in patients with colorectal cancer
... by hypoxia, necrosis and ...with hypoxia, such as HIF1A (hypoxia-inducible factor 1-alpha) and VEGF (vascular endothelial growth factor), and with lipid metabolism, ...
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Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach
... in hypoxia-inducible factor 1 alpha (HIF1α) and proliferating cell nuclear antigen (PCNA) in both BxPC-3 and MIA PaCa-2 pancreatic cancer cells (Figure ...fact, hypoxia is known ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... of hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent upregulation of vascular endothelial growth factor (VEGF) could contrib- ute further basement membrane damage [8]; ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... the hypoxia-inducible factor-1 alpha (HIF-1 α ), vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and micro- vessel density (MVD) marked by ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... one-way analysis of variance (ANOVA) with Tukey’s adjustment to compare three or more groups (for ex- ample, different treatment types, time points, and so on); and 3) a two-way ANOVA with Bonferroni ad- justment (for ...
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The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients
... Patients suspected of having lung cancer were prospec- tively recruited between October 2005 and October 2008. The inclusion criteria were as follows: (1) patients had a pathologically-confirmed diagnosis of NSCLC ...
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