Hypoxia inducible factor α
The hypoxia inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
... Skeletal development and turnover occur in close spatial and temporal association with angiogenesis. Osteo- blasts are ideally situated in bone to sense oxygen tension and respond to hypoxia by activating the ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... HIF-1 α is inherently expressed in AI-resistant cells, upregulated by HER2-PI3K/Akt-mTOR pathway and is an important factor in letrozole-resistant breast cancer cells, regulating target genes such as BCRP ...
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Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes
... HIF-1 α siRNA (human), control HIF-1 α siRNA (fluorescein isothiocyanate [FITC] conjugate)-A, anti-HIF-1 α antibody, goat anti-rabbit IgG-HRP, and GAPDH antibody were purchased from Santa Cruz ...
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Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α
... potential factor in determining HIF1 a expression and ...HIF1a, hypoxia- inducible factor-1-a; hPASMCs, human pulmonary arterial smooth muscle cells; RIPK1, receptor-interacting ...
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Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function
... B α , but no functional consequence of this interaction with respect to NF- κ B- dependent ...of hypoxia-induced NF- κ B message in murine bone-marrow-derived neutrophils ...
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Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma
... carcinoma. Hypoxia inducible factor-1 α (HIF-1 α ) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene ...
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Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment
... transcription factor 4; CHOP: CCAAT/enhancer-binding protein homologous protein; ER: Endoplasmic reticulum; GRP78: Glucose-regulated protein 78; GSK3- β : Glycogen synthase kinase 3-beta; HIF-1 α : ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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Gene expression of vascular endothelial growth factor A and hypoxic adaptation in Tibetan pig
... : hypoxia-inducible factor 1 α ; HREs: hypoxia response elements; PIEC: pig iliac endothelial cells; qRT-PCR: quantitative real-time PCR; SDS-PAGE: sodium dodecyl sulfate polyacrylamide ...
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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... anti-hypoxia-inducible factor (HIF)-1 α antibody (Santa Cruz Biotechnology), anti- HIF-1 β antibody (Cell Signaling Technology Inc, Danvers, MA), anti-VEGF antibody (Santa Cruz Biotechnology), ...
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Expression of relative-protein of hypoxia-inducible factor-1α in vasculogenesis of mouse embryo
... Periodic Α cid Schiff (PAS)-positive network, that mimics the pattern of embryonic vasculogenic ...that hypoxia-inducible factor-1 α (HIF-1 α ) can induce tumor cells to form ...
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Endothelial cell pseudopods and angiogenesis of breast cancer tumors
... of hypoxia inducible factor 1- α (HIF) reveals the subcortical area of the tumor to contain HIF positive cells while the tumor capsule, cortex and necrotic areas of the tumor demonstrate no ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... H: hypoxia; HACE: high-altitude cerebral edema; HIF-1 α : hypoxia-inducible factor 1 alpha; Hg: mercury; HRP: horse radish peroxidases; ICAM: intercellular adhesion molecule; IKB: ...
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Telomeres are elongated in rats exposed to moderate altitude
... to hypoxia for 1, 3, 7, 15, or 30 days (n = ...(TERT), hypoxia-inducible factor 1 α (HIF-1 α ), malondialdehyde (MDA) and superoxide dismutase (SOD) were ...
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Science review: Redox and oxygen sensitive transcription factors in the regulation of oxidant mediated lung injury: role for hypoxia inducible factor 1α
... nium, which blocks the conversion of ubiquinone to ubiquinol, abrogated IL-1 β -dependent and TNF- α -dependent nuclear translocation and activation of HIF-1 α . Similarly, interrupting the respiratory ...
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Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer
... with hypoxia inducible factor 1 α and with Gleason pattern and score, as well as with the novel grading system proposed by the International Society of Urological Pathology for prostate ...
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Macrophages: friend or foe in idiopathic pulmonary fibrosis?
... that hypoxia-inducible factor 1-α (HIF-1α) enhances ADORA2B expression to regulates M2 macrophage differ- entiation and production of profibrotic mediators ...
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Emerging evidence of the physiological role of hypoxia in mammary development and lactation
... During hypoxia, tissues undergo a series of physiological responses to defend themselves against a low oxygen supply, including increased angiogenesis, erythropoiesis, and glucose ...of hypoxia are mainly ...
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Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1α and Ki67 in human gastric cancer
... the hypoxia response elements in the DEC1 promoter and found that the DEC1 gene is a direct target of hypoxia-inducible factor 1 ...a hypoxia-regulated gene, so its expression in human ...
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Atlas on substrate recognition subunits of CRL2 E3 ligases
... Genome-wide chromatin immunoprecipitation experiments revealed that PRAME is specifically enriched at enhancers and at transcriptionally active promoters that are also bound by nuclear transcription factor Y ...
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