hypoxia-inducible factor alpha
Original Article Acute exposure to hypobaric hypoxia upregulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor
... hypobaric hypoxia alters the mRNA expression levels of hypoxia-inducible factor alpha (HIF-1α) and VEGF as well as VEGF pro- tein ...
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Original Article LDHA is a feedback activator of hypoxia inducible factor 1-alpha in ovarian cancer
... by hypoxia, indicating that up-regula- tion of LDHA in ovarian cancer was HIF-1α- ...under hypoxia, indicating that a feedback was existed between LDHA and HIF-1α (Figure ...
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Hypoxia-inducible factor 1 alpha expression is an indicator of invasiveness in uterine cervical tumors
... Background: Hypoxia is a common feature of cancers. Hypoxia-inducible factor 1A (HIF1A) is a causative agent that changes the transcriptional response of tumors under ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... [2,3]. Hypoxia inhibits this process, resulting in upregulation of HIF-1 α and its downstream target genes ...hand, hypoxia-independent upregulation of HIF- 1 α may be accomplished by loss of tumor ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... of hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent upregulation of vascular endothelial growth factor (VEGF) could contrib- ute further basement membrane damage [8]; (iii) ...
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Type H blood vessels in bone modeling and remodeling
... 14]. Hypoxia-inducible factor 1 alpha (HIF-1α), Notch, and VEGF signaling, which are well known factors in the vascular field that induce EC proliferation, migration, and vessel formation, are ...
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... intermittent hypoxia in OSAHS identified two molecular pathways: A nuclear factor-κB (NF-κB)-dependent inflammatory pathway, which produces inflammatory cytokines, and hypoxia-in- ducible ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... factors. Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing the expression ...
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Original Article Profilin-1 mediates microvascular endothelial dysfunction in diabetic retinopathy through HIF-1α-dependent pathway
... and hypoxia inducible factor-1 alpha (HIF-1α) in cultured human retinal microvascular endothelial cells (HRMECs) treated with high glucose and in 6 month-old Sprague-Dawley (SD) rats with ...
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Original Article mRNA expression level and clinical value of hypoxia inducible factor 1 alpha in patients with myelodysplastic syndromes: a fluorescence quantitative real-time RT-PCR study
... Abstract: Objective: The clinical value and prospective function of hypoxia inducible factor 1 alpha (HIF-1α) in my- elodysplastic syndromes (MDS) remain poorly understood. Therefore, the ...
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Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach
... in hypoxia-inducible factor 1 alpha (HIF1α) and proliferating cell nuclear antigen (PCNA) in both BxPC-3 and MIA PaCa-2 pancreatic cancer cells (Figure ...fact, hypoxia is known to ...
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Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma: a meta-analysis
... lower OS and DFS rates were found in patients with HIF-1 α overexpression, indicating poor prognostic value of HIF-1 α expression in osteosarcoma. It is reasonable to infer that hypoxia would be more evident when ...
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Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer
... chemotherapy. Hypoxia-inducible factor (HIF)-1α is the key transcription factor that mediates cellular response to ...the hypoxia-mimetic agent cobalt ...by hypoxia. ...
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Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
... i Alpha 2; Cre, Cre recombinase; Cre-eR, Cre recombinase fused to a triple mutant form of the humanoestrogen receptor; Cre-eRT2, estrogen receptor T2 which activates Cre when exposed to tamoxifen; epo, ...
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Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells
... HIF-1 alpha overexpres- sion on the metabolic state of MSCs, we performed mitochondrial and glycolysis stress tests to compare the OCR and glycolysis, respectively, between HIF-MSCs with control ...HIF-1 ...
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Prognostic value of factors associated with hypoxia and lipid metabolism in patients with colorectal cancer
... by hypoxia, necrosis and ...with hypoxia, such as HIF1A (hypoxia-inducible factor 1-alpha) and VEGF (vascular endothelial growth factor), and with lipid metabolism, ...
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Study on the Expressions of PHD and HIF in Placentas from Normal Pregnant Women and Patients with Preeclampsia
... the alpha subunit of the hypoxia-inducible transcription factor (HIF) and controls its stability in an oxy- gen-dependent ...in hypoxia, HIFα evades degradation and forms a functional ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... one-way analysis of variance (ANOVA) with Tukey’s adjustment to compare three or more groups (for ex- ample, different treatment types, time points, and so on); and 3) a two-way ANOVA with Bonferroni ad- justment (for ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients
... Hypoxia-inducible factor 1a (HIF-1a) controls oxygen delivery via angiogenesis and metabolic adaptation to hypoxia via glycolysis [3]. HIF-1a regulates SLC2A1 gene expression in cells that are ...
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