Hypoxia-Inducible Factor Pathway
The Regulation and Interactions of the Hypoxia Inducible Factor Pathway in Carcinogenesis and Potential Cancer Therapeutic Strategies
... Under hypoxic conditions HIF-1 α binds to the intracellular domain of Notch and augments the downstream res- ponses of the Notch ICD/ CSL transcription complex [47]. In order to elucidate the correlation between the two ...
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Resveratrol Inhibits Hypoxia Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
... inhibited hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) via the PI3K/Akt ...or hypoxia for 16 ...the hypoxia-induced HIF-1α protein accumulation ...
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Surviving ischemia: adaptive responses mediated by hypoxia inducible factor 1
... response pathway fail to provide suf- ficient neovascularization in patients with coronary artery disease to prevent ischemia? One major differ- ence is that the fetal sheep heart is a growing organ that is ...
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Upregulated hypoxia inducible factor 1α and 2α pathway in rheumatoid arthritis and osteoarthritis
... The direct association of the extent of HIF-1α with MVD and the VEGF/KDR activated MVD in OA is consistent with the notion that VEGF is induced by hypoxia after activation of the HIF-α pathway. This is ...
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Original Article 14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/ Akt/NF-кB signal transduction pathway
... of hypoxia treatment, which would fur- ther increase the expression of VEGF, MMP-2, MMP-9 and lead to the metastasis of tumors [7, ...of hypoxia in stabilizing the expres- sion of 14-3-3ζ by reducing its ...
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The hypoxia inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
... transcription factor 2 (Runx2) and OC, markers for early and late osteoblast differentiation, respectively, was not significantly altered in the Vhl-deficient cells (Figure ...
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Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function
... major pathway for sustainable production of ATP utilizes oxygen in the mitochondrial electron transport system, the process known as oxidative ...in hypoxia [3] and the profound effects of hypoxia on ...
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Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
... environment hypoxia had been ...of hypoxia-inducible factor. The hypoxia-inducible factor hydroxylase pathway regulates a massive transcriptional cascade that is ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... HER2-PI3K/Akt-mTOR pathway and is an important factor in letrozole-resistant breast cancer cells, regulating target genes such as BCRP and regulating AI responsiveness and cancer stem cell char- acteristic ...
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Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
... Catabolism of glutamine is another key metabolic pathway for cancer cells. End products of glutaminoly- sis serve as intermediates for TCA cycle. Like glycoly- sis, glutaminolysis provides not only ATP but also ...
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Geochemical Signatures of Stream Capture in the Retreating Blue Ridge Escarpment, Southern Appalachian Mountains
... Cancer is one of the leading causes of death, second only to heart disease. 1 One of the hallmarks of cancer is the formation of hypoxic areas inside of solid tumors. 2 This hypoxic tumor microenvironment leads to many ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia inducible factor 1α
... to hypoxia-induced weight loss are also complex and incompletely ...growth factor (IGF) pathway (41, 42), which in turn is regulated by hypoxia ...a hypoxia response element with an ...
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Original Article Specific silencing of hypoxia inducible factor-1α, hypoxia inducible factor-2α and hypoxia inducible factor-1β by small interference RNA reduces the expression of vascular endothelial growth factor in BGC-823 gastric cancer cells under hypoxia
... of hypoxia-inducible factor (HIF)-1α, HIF-2α and HIF-1β on vascular endothelial growth factor (VEGF) expression in BGC-823 gastric cancer cells under ...Methods: Hypoxia model was ...
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Inhibition of calcium uptake during hypoxia in developing zebrafish is mediated by hypoxia inducible factor
... transcription factor hypoxia-inducible factor-1 (HIF-1) plays a critical role in promoting cellular responses to reduced oxygen levels (Jewell et ...a hypoxia-responsive α subunit and ...
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Further investigation into the roles of vascular endothelial growth factor and thymidine phosphorylase in urological malignancy
... There are 2 VEGF receptor tyrosine kinases, Flt-1 (VEGFR-1) and KDR (VEGFR-2) (68, 69). Both are expressed primarily on vascular endothelial cells although Flt-1 has been identified on monocytes. KDR can mediate the ...
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Original Article Correlation between BOLD-MRI and HIF expression level in renal carcinoma
... without using contrasts. It has been widely applied in various kidney diseases including chronic renal failure, kidney transplantation, hypertensive kidney dysfunction, ischemic renal injury and renal tumors [8, 9]. One ...
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Hypoxia promotes fibrogenesis in vivo via HIF 1 stimulation of epithelial to mesenchymal transition
... substantial evidence of hypoxia in this assay, whereas a low level of hypoxia was detected in subcortical tubular epithelial cells on day 8. We monitored the stabilization of Hif-1α and Hif-2α protein in ...
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Original Article Acute exposure to hypobaric hypoxia upregulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor
... Commercial aircraft pressurization can provide a “shirt-sleeve environment” within the cabin, with an equivalent altitude of 8,000 ft, while the aircraft can operate up to approximately 40,000 ft. In contrast, military ...
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Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions
... can be upregulated in response to hypoxia, inducing the angiogenic switch [36]. We find almost equal expression of VEGF in cancer and HSIL samples (70% and 71.4% respectively); however, higher number of cancer ...
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