Hypoxia-inducible factors
The role of hypoxia-inducible factors in leukemias
... Hypoxia, understood as low partial oxygen pressure, has become one of the most explored fields in recent years. Cellular response to hypoxia is mediated by hypoxia-inducible factors ...
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Validation of Antibodies Used to Study Hypoxia Inducible Factors in Two Species of Fundulus
... Hypoxia inducible factors (HIFs) are transcription factors and the master regulators of oxygen-dependent gene expression in animals. The focus of this thesis is the distribution of HIF protein ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors
... and hypoxia-inducible factors (HIFs) play an important role in the Kaposi’s sarcoma-associated herpesvirus (KSHV) life ...particular, hypoxia can activate lytic replication of KSHV and ...
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Role of Hypoxia Inducible Factors in Obesity Pathogenesis
... [3,4]. Hypoxia could be the answer of what induces the chronic inflammation of adipose tissue (AT) in obesity ...[5]. Hypoxia in obese state may also account the ischemia/reperfusion injury in the AT ...to ...
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Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice
... ia-inducible factors-1alpha (HIF-1α) on mo- nocytes and macrophages can be increased ...(14). Hypoxia-inducible factors-1α can also increase the levels of vas- cular endothelial growth ...
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Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics
... consequent hypoxia is a component of many human ...to hypoxia is mediated by hypoxia inducible factors (HIF1–3), the oxygen-sensitive signal being generated by a series of protein ...
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Hypoxia inducible factors: key regulators of myeloid cells during inflammation
... that hypoxia-in- duced inhibition of neutrophil apoptosis is dependent on HIF-1α (106), and that HIF-1α is required for phagocytes to fully exert their bactericidal activity ...
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Hypoxia inducible factors: a central link between inflammation and cancer
... Tumor hypoxia has an essential role in regulating tumor inflam- matory cell functions in addition to regulating immune cell recruit- ment (Figure ...tumor hypoxia regulates TAM expression of VEGF, ...
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Hypoxia and hypoxia-inducible factors in chronic kidney disease
... renal hypoxia plays an important role in the progression of chronic kidney disease ...renal hypoxia and hypoxia-inducible factor (HIF), a master regulator of cellular adaptation to ...
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Hypoxia inducible factors and the prevention of acute organ injury
... DNA hypoxia- responsive elements by small ubiquitin-like modifi ers (SUMO) and factor inhibiting HIF (FIH), and the eff ect of reactive oxygen species (ROS), NO and Krebs cycle metabolites on HIF ...
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Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis
... in hypoxia, because in the HIF-3α pro- moter region there are hypoxia response elements (HRE), characteristic of the genes that are targeted by HIF-1α ...
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Regulation of obesity and insulin resistance by hypoxia-inducible factors
... One can then reason that restoring blood perfusion into adipose tissue may attenuate adipose tissue hypoxia and adipocyte dysfunction in obesity. Several groups attempted to address this by modulating vasculature ...
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Hypoxia Inducible Factors in Cancer and Inflammation
... transcription factors are effectively targeted for cancer therapeutics in the future, HIF inhibition in the tumor microenvironment by a safe, naturally occurring compound, in the setting of inflammation-driven ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... i.e. hypoxia and how curcumin affects this architecture under hypoxia has not been ...that hypoxia induce an inflammatory response [14] that could further impair organ function through leukocytes ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... whereas oxygen-independent overexpression results in a dif- fuse pattern of HIF-1 α immunoreactivity [11,36,37]. Necrosis was found in the stromal component of only one malignant phyllodes tumor. Furthermore, stromal ...
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Hypoxia induced p53 modulates both apoptosis and radiosensitivity via AKT
... tumor hypoxia have a worse prognosis irrespective of treatment modality ...Importantly, hypoxia induces a DDR in the absence of detectable DNA damage ...and hypoxia (<0.1% O 2 ) (10). Tumor ...
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Oxidation in rheumatoid arthritis
... with hypoxia in an additive manner to induce VEGF expression by fibroblast-like synoviocytes ...both hypoxia and TNF- α ...by hypoxia occurs in the context of multiple other regulatory pathways, ...
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Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1
... normoxic cells with light microscopy. The SLPI content in medium and rinsing fluids was analysed with ELISA. SLPI was mostly released into the baso-lateral medium (349 ± 25 ng/ml) compared to the rinsing fluid (53 ± 12 ...
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Science review: Redox and oxygen sensitive transcription factors in the regulation of oxidant mediated lung injury: role for hypoxia inducible factor 1α
... The molecular response to oxidative stress is regulated by redox-sensitive transcription factors [55–60]. The study of gene expression and regulation is critical in the development of novel gene therapies [61–70]. ...
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S Nitrosothiols signal hypoxia mimetic vascular pathology
... NO transfer reactions between protein and peptide cysteines have been proposed to represent regulated signaling processes (1, 2). For example, NO transfer from deoxygenated erythrocytes to glutathione ex vivo forms ...
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