Hypoxia reoxygenation
Role of Xanthine Oxidase and Its Inhibitor in Hypoxia: Reoxygenation Injury
... Role of Xanthine Oxidase and Its Inhibitor in Hypoxia: Reoxygenation Injury. Services[r] ...
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Original Article Effects of omi/HtrA2 on hypoxia/reoxygenation-induced apoptosis of rat renal tubular epithelial cells
... after hypoxia/ ...after hypoxia/reoxygenation in the shRNA1 and shRNA2 groups, suggesting that knockdown of Omu/HtrA2 decreased apopto- sis (Figure ...
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Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
... est hypoxia with exposure to 10% ...however, hypoxia/reoxy- genation is not expected to result in much of an inflammatory response in normal mice in which no sickling (and therefore no ischemia) is ...mice, ...
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XuefuZhuyu decoction protected cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy
... Background: XuefuZhuyu decoction (XFZY) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as unstable angina pectoris and myocardial ischemia-reperfusion ...
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Original Article Effect of metformin on myocardial cell apoptosis induced by hypoxia/reoxygenation injury
... establish hypoxia/reoxygenation injury (H/R) models of myocardial cells in vitro and the models were randomly classified into four groups: blank control group, metformin group, H/R group and metformin + H/R ...
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N -n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells
... to hypoxia and plays a crucial role during I/R injury [3]. During hypoxia/reoxygenation (H/R), endothelial cells exhibit a proinflammatory phenotype, including the induction of vasoconstrictive ...
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Original Article Effects of red blood cell supernatants on hypoxia/reoxygenation injury in H9C2 cells
... to Hypoxia/Reoxygenation (H/R) injury. Method: Hypoxia-treated H9C2 cells were treated with RBC supernatants that had been stored for 0 or 35 ...
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PEP 1 CAT protects hypoxia/reoxygenation induced cardiomyocyte apoptosis through multiple sigaling pathways
... the hypoxia-reoxygenation (H/R)-induced apoptosis model to investigate the mechanisms under- lying the anti-apoptotic effect of PEP-1-CAT in H9c2 ...
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N -n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy
... N-n-butyl haloperidol iodide (F 2 ), a novel compound derived from haloperidol, protects against the damaging effects of ischemia/reperfusion (I/R) injury in vitro and in vivo. In this study, we hypothesized the ...
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
... the inhibition of ATF6 in mice using 4-(2-aminoethyl) benzenesulfonyl fluoride further developed cardiac remodeling in ischemic heart and cause higher mortality rate [134]. Another effector of the UPR that preserves the ...
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Original Article Silencing Rac1 protects H9c2 cells against hypoxia-reoxygenation injury by inactivation of notch pathway
... with hypoxia-reoxygenation (H/R) ...observed. Reoxygenation treatment provoked decline in the H9c2 cell viability in a time-dependent manner and about ...
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Effects of Cornus Officinal Is Total Glycoside on Cardiomyocyte Apoptosis and Calcium Overload after Hypoxia/Reoxygenation Injury in Rats
... Objective: To investigate the mechanism of Cornus officinalis Total Glycosides (COTG) on myocardial protection, by studying effects of COTG on cardi- omyocyte apoptosis induced by hypoxia/reoxygenation and ...
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Original Article Inhibition of CLU4A exhibits a cardioprotective role in hypoxia/reoxygenation-induced injury by an ERK-dependent pathway
... that hypoxia/ reoxygenation treatment caused a dramatic increase in LDH release in H9c2 cells, and tr- ansfection of si-CLU4A effectively blocked the increase of LDH activities compared with the si-NC group ...
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<p>Co-loading antioxidant N-acetylcysteine attenuates cytotoxicity of iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes</p>
... Abbreviations: NPs, nanoparticles; TEM, transmission electron microscopy; LDH, lactate dehydrogenase; H/R, hypoxia/reoxygenation; MNP, magnetic iron oxide nanoparticles; MSN, mesoporous [r] ...
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Calcium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation
... Although it has been demonstrated that CaR (calcium sensing receptor) activation is involved in intracellular calcium overload during hypoxia/reoxygenation (H/Re), the role of CaR acti[r] ...
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Original Article Dexmedetomidine reduces hypoxia/reoxygenation injury by regulating mitochondrial fission in rat hippocampal neurons
... After 8 d cultivation, the primary hippocampal neurons were randomly divided into six groups: control group C group; vehicle group V group; H/R group; H/R+DEX treatment groups: of P1, P2[r] ...
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Intervention and Mechanism of Dexmedetomidine on A549 Cells Injured by Hypoxia/Reoxygenation
... starved for 24h,Then cells were cultured with sugar-free OGD solution, hypoxia for 6h. The culture medium was replaced with serum-free F12K medium ， reoxygenation for 24h .This is the establishment of H/R ...
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Propofol Attenuates Hypoxia/Reoxygenation Induced Apoptosis and Autophagy in HK 2 Cells by Inhibiting JNK Activation
... levels of autophagy. This alteration was partially reversed by 50 μM propofol or 10 μM SP600125 (50 μM propofol versus H/R, p<0.01; 10 μM SP600125 vs. H/R, p<0.01). Like our findings with apoptosis, the combination ...
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Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways
... subsequent reoxygenation upon reperfusion are thought to be the major culprits contributing to reactive oxygen species (ROS) production which leads to uncontrolled oxidative stress and the sub- sequent cell ...
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Original Article Capsaicin reduces intrinsic apoptosis induced by hypoxia/reoxygenation in rat alveolar type II cells
... trast to this, we used the RLE-6TN cell line derived from ATII cells, which are believed to play a much more pivotal role than ATI cells in maintaining tissue homeostasis via epithelium restoration [22]. It is widely ...
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