Hypoxic pulmonary vasoconstriction
Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction
... in hypoxic pulmonary vasoconstriction (HPV), we measured the increase in left lung pulmonary vascular resistance (LPVR) before and during hypoxia produced by left main stem bronchus occlusion ...
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Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels
... the pulmonary arteries constrict, diverting blood flow to better ventilated areas of the lung where gas exchange can take place more ...‘hypoxic pulmonary vasoconstriction’ (HPV), and is ...
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Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction
... impaired pulmonary gas exchange. Hypoxic pulmonary vasoconstriction (HPV) optimizes gas exchange during local acute (0-30 min), as well as sustained (> 30 min) hypoxia by matching blood ...
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Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6
... 8. Owsianik G, Talavera K, Voets T, Nilius B: Permeation and selectivity of TRP channels. Annu Rev Physiol 2006, 68:685-717. 9. Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, Olschewski A, Storch U, ...
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Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
... Maurizio Turzo 1 , Julian Vaith 1 , Felix Lasitschka 2 , Markus A. Weigand 1 and Cornelius J. Busch 1* Abstract Background: ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved ...
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Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs
... Introduction The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction ...
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Role of Cytochrome P 450 in Alveolar Hypoxic Pulmonary Vasoconstriction in Dogs
... induces pulmonary vasoconstriction by an unknown ...modify pulmonary vascular tone via its sensitivity to changes in oxygen tension or by affecting metabolism of a chemical ...alveolar hypoxic ...
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A pig model of acute right ventricular afterload increase by hypoxic pulmonary vasoconstriction
... by hypoxic pulmonary ...acute pulmonary hypertension combined with regionally or globally reduced right ventricular contractile ...the pulmonary circulation is a low-pressure system that needs ...
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Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction
... Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular ...
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Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure
... Abstract Hypoxic pulmonary vasoconstriction continues to attract interest more than half a century after its original report because of persistent mystery about its biochemical mechanism and its ...
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Effects of human relaxin-2 (serelaxin) on hypoxic pulmonary vasoconstriction during acute hypoxia in a sheep model
... Dovepress Hypoxic pulmonary vasoconstriction and serelaxin since we already employed similar experimental models in earlier studies, it represents a potential limitation of this ...human ...
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Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction
... signaling, pulmonary vasoconstriction, mitochondria Received: January 07, 2016 Accepted: April 02, 2016 Published: April 21, 2016 ABSTRACT Hypoxia triggers pulmonary vasoconstriction, however ...
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Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia
... The current study used expression microarrays to iden- tify one or more genes that might contribute, together with NO, to the endotoxin-induced impairment of HPV. Transcriptional profiling revealed that Arg1 was the most ...
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Failure of hypoxic pulmonary vasoconstriction in patients with liver cirrhosis
... low pulmonary vascular resistance in patients with liver cirrhosis is ...unexplained. Pulmonary microcirculatory dilation, but not gross arterio- venous shunts, has been the usual postmortem finding in ...
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Influence of Prostaglandin Synthesis Inhibitors on Pulmonary Vasodilatory Effects of Hydralazine in Dogs with Hypoxic Pulmonary Vasoconstriction
... To ascertain the contribution of the prostaglandin system to the pulmonary vasodilator effects of hydralazine, we pretreated a group of dogs with the prostaglandin synthetase inhibitor, [r] ...
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Hypoxic pulmonary vasoconstriction requires connexin 40–mediated endothelial signal conduction
... perfused lung and in cultured PAECs by indirect immunofluorescence, as previously described (27, 66). This assay stains specifically for translocated (i.e. membrane-bound) as opposed to nonactivated, cytoplasmic cPLA 2 . ...
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Nonadrenergic effects of isoproterenol in dogs with hypoxic pulmonary vasoconstriction Possible role of prostaglandins
... significantly reduced PAPm and PVR. The responses to isoproterenol were comparable in the presence or absence of propranolol; at 0.05 micrograms/kg per min the effects of isoproterenol were blunted, but not abolished, by ...
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Failure of Hypoxic Pulmonary Vasoconstriction in the Canine Asthma Model: EFFECT OF PROSTAGLANDIN INHIBITORS
... and pulmonary vascular resistance were made before and 15 min after inhalation challenge with Ascaris suum extract in dogs with natural sensitivity to this ...
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Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice
... Baseline pulmonary artery pressure during normoxic ventilation; ...baseline pulmonary artery pressure (= PAP) during ventilation with 21 % O 2 in lungs obtained from saline-treated controls (open bars) and ...
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Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium dependent relaxation
... in hypoxic constriction of the intact pulmonary vascular bed has not been clearly ...the hypoxic pressor response, isolated, whole blood-perfused rat lungs from male Sprague-Dawley rats treated with ...
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