I-kappa B Kinase
Design, synthesis, and biological evaluation of novel <strong>EF24 </strong>and <strong>EF31 </strong>analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer
... inhibitory kappa B (IκB) kinase β (IKKβ) plays in pancreatic cancer (PC) development and progression, inhibitors targeting IKKβ are believed to be increasingly popular as novel anti-PC ...Through ...
13
Examining novel roles for the I[kappa]B kinase in coordinating the cellular response to metabolic stress
... An interesting them that emerges is the relative proximity of the IKK and mTOR complex. These two complexes seem to respond to starvation and amino acid deprivation with the same kinetics and modulate effectors within ...
113
Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ− and STZ+ niacinamide-induced diabetes in rats
... proteins, I kappa Bs ...protein kinase, the I kappa B kinase (IKK), leading to phosphorylation of two critical serines in the N-ter- minal regulatory domain of IκBs, ...
11
A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases
... protein kinase (HIPK) 2 and 3, I-kappa B Kinase (IKK), mitogen-activated pro- tein kinase 1 (MAPK2/ERK2), ribosomal protein S6 kinase, 90 kDa, polypeptide 1 and 3 ...
10
PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms.
... protein kinase A site that is present in all Rel family members except for the protein encoded by the nfkb2 ...and I k B- a -mediated mechanisms, dimerization, cellular localization, and oncogen- ...
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Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
... β kinase subunit were utilized to investigate the potency of both compounds against agonist-stimulated IKK α -regulated NF- κ B transcriptional acti- ...κ B-luciferase promoter gene. NF- κ B ...
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Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.
... k B in a cPKC-independent fashion (46), we de- termined whether PKC isoenzymes other than those suscepti- ble to the PKC inhibitor GF (60) that could mediate NF- k B activation were present in these ...k ...
9
An investigation of the function of I[kappa]B family member Bcl-3 and its role in oncogenesis
... The ability of Bcl-3 to activate transcription of genes such as the anti-apoptotic Bcl-2 and cell cycle activator cyclin D1 has been suggested to contribute to its oncogenicity, but direct links from these activities to ...
135
The regulation of constitutive NF-[kappa]B activity by glycogen synthase kinase-3 in pancreatic cancer
... (2) How does phosphorylation of TAK1 as serine 412 modulate TAK1 signaling? The phosphorylation of TAK1 at serine 412 resides outside the catalytic domain and suggests that this phosphorylation event does not control ...
127
LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha.
... k B activation, our results suggest that LMP-1 causes continuous modifications of I k B a by at least two mechanisms: phosphorylation and ...resemble I k B a modifications induced by ...
7
<p>The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7</p>
... UA was purchased from the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China). Human breast cancer MCF-7 cells were obtained from Shanghai Cell Bank of Chinese Academy of Science ...
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<p>Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα</p>
... Results: Knockdown of Ufm1 by lentivirus shRNA targeting Ufm1 (Lv-shUfm1) led to decreased secretion of IL-6, IL-1 β , ICAM-1, VCAM-1, MCP-1 and CXCL2 in RAW264.7 cells that were exposed to LPS and TNF- α , while ...
16
<em>Ginkgo biloba</em> extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling
... GBE (the national drug standard substance) was purchased from the Chinese Food And Drug Inspection Institute, Beijing, People’s Republic of China. CCl 4 was purchased from Shanghai Jinghua Scientific & Technological ...
15
Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection
... Methods: The apoptosis of RD cells was examined using annexin V-FITC/PI by flow cytometry and cytokines were detected by ELISA. Cellular RNA was extracted and transcribed to cDNA. PCR array was employed to analyze the ...
12
Tanshinol ameliorates CCl<sub>4</sub>-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
... tion was determined by using a bicinchoninic acid (BCA) pro- tein assay kit. Proteins were separated by 12% or 15% sodium dodecylsulfate-polyacrylamide gels and transferred onto poly- vinylidene fluoride membranes. Then, ...
12
Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.
... cytoplasm. I k B molecules with these fea- tures include I k B a (2, 4, 28, 30), I k B b (74), pp40 (17), I k B g (32), and the precursor proteins of p50 and ...
10
Avian I kappa B alpha is transcriptionally induced by c-Rel and v-Rel with different kinetics.
... k B binding site as well as the potential AP1 and second NF- k B binding sites (p40D3-luc) rendered the I k B a promoter virtually unresponsive to either c-Rel, c-Rel D , or ...k B ...
8
OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D
... Type I diabetes (T1D), a common chronic childhood dis- ease, is characterized by insulin deficiency caused by the progressive destruction of pancreatic beta-cells by auto- immune processes ...
6
Control of axis formation in Xenopus by the NF kappa B I kappa B system
... Int J !)e" l\iol 39 5 19 558 (1995) 549 Original Article Control of axis formation in Xenopus by the NF KB h(Bsystem DAVID TANNAHill" and FIONA C WARDLE' Department of Anatomy, University of Cambridge[.] ...
10
Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.
... Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor KB and induces nuclear translocation of transcription factor NF-KB proteins for transcr[r] ...
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