ICG fluorescence-guided surgery
Near-infrared Intraoperative Imaging of Thoracic Sympathetic Nerves: From Preclinical Study to Clinical Trial
... (ICG) fluorescence guided surgery (ICG-FGS) in a case report ...Notably, ICG has been authorized by the Food and Drug Administration (FDA) for determining cardiac output, hepatic ...
10
A Tumor-Activatable Theranostic Nanomedicine Platform for NIR Fluorescence-Guided Surgery and Combinatorial Phototherapy
... preferable fluorescence characteristics, ICG is widely utilized in clinical research, especially in NIR fluorescence image-guided oncologic surgery for the identification of solid ...
18
<p>NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green</p>
... ICG can also be conjugated to chlorotoxin. 97 An amine- reactive ester form of ICG was conjugated to chlorotoxin using standard amine-reactive chemistry; the conjugate was termed BLZ-100. The chlorotoxin is ...
16
A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery
... before surgery based on clinical and logistical ...tissue ICG is retained for some ...with ICG injection up to 14 days before surgery, although using much higher doses of ICG, up to ...
18
Liver segment imaging using monocyte sequestration: a potential tool for fluorescence-guided liver surgery
... and ICG have comparable molar extinction coefficients [32, 33], IRDye800CW-conjugated antibodies and proteins have substantially higher fluorescence quantum yields than ICG-conjugated [34, ...for ...
10
Fluorescence-guided cancer surgery : clinical translation of tumor-targeted agents
... nir fluorescence imaging leads to more accurate detection of (occult) ovarian can- cer metastases, more patients could be optimally staged, possibly leading to better treatment decision making and overall ...nir ...
84
<p>IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer</p>
... Over the past several years, intraoperative near-infra- red (NIR) fl uorescence imaging was developed as a novel technique for guiding surgeons in the detection and resec- tion of residual malignant disease not detectable ...
16
Intraoperative Imaging-Guided Cancer Surgery: From Current Fluorescence Molecular Imaging Methods to Future Multi-Modality Imaging Technology
... and ICG conjugated trastuzumab to target against HER2, to evaluate the feasibility of specifically detecting breast cancer cells in vitro and in ...and fluorescence microscopy analyses ...
13
Macro and microscopic findings of ICG fluorescence in liver tumors
... a fluorescence signal [1]. ICG fluorescence imaging (IFI) is increasingly being used in fluorescence-guided surgery, ...using fluorescence imaging and generally have ...
9
Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer
... 4B), fluorescence-based assessment revealed an ...a fluorescence read- out seems to be related to a combination of the superior brightness of the Cy5 dye (Table 1; Supplemental Table 1), the tissue pene- ...
8
Novel imaging system for positioning of the indocyanine green (ICG) target; visible projection of the near infrared fluorescence image
... NIR fluorescence imaging has many advantages in SLN mapping and cancer detection, NIR fluorescence imaging shows a serious drawback that NIR cannot be detected by the naked eye without any ...NIR ...
5
Polydopamine Nanoparticles as a Versatile Molecular Loading Platform to Enable Imaging-guided Cancer Combination Therapy
... the fluorescence of DOX was quenched by 92% after loading on nanoparticles compared with same concentration of free DOX, also suggesting the strong interaction between DOX and PDA-ICG-PEG (Supplementary ...
12
Longitudinal adaptive optics fluorescence microscopy reveals cellular mosaicism in patients
... the fluorescence of RPE cells above vessels would be higher than the fluorescence above flow voids, which is the opposite of what our data ...in fluorescence (there is a subset of cells that change ...
18
Biomineralization-inspired Crystallization of Manganese Oxide on Silk Fibroin Nanoparticles for in vivo MR/fluorescence Imaging-assisted Tri-modal Therapy of Cancer
... Characterizations of SMID nanoparticles The morphology of SMID nanoparticles and intermediate products of each synthetic step was recorded by both transmission electron microscopy (TEM, JEM-2100, JEOL, Japan) and field ...
20
<p>ICG-Loaded PEGylated BSA-Silver Nanoparticles for Effective Photothermal Cancer Therapy</p>
... as ICG) via tail vein ...FOBI Fluorescence In Vivo Imaging System (NeoScience ...The ICG contents in the tissues were quantified by measuring the absorbance at 790 nm after the homogenization of ...
13
Nerve-targeted probes for fluorescence-guided intraoperative imaging
... FAM-HNP401 and FAM-NP41 were tested for binding to autonomic nerves, isolated from the prostate glands of two human patients (Figure 4 and Figure S9). FAM-HNP401 (Figure 4A and Figure S9A) showed a significantly higher ...
12
Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin
... This study proves the effectiveness of using fluorescently- controlled resection in brain surgery for glioma. The method demonstrated here permits more thorough resection of the tumor mass; such surgical ...
7
Multimodal imaging guides surgical management in a preclinical spinal implant infection model
... orthopedic surgery, as surgical implants provide a safe haven for recalcitrant, biofilm-associated ...spinal surgery, as infection can lead to destabilization of the spinal column, multiple reoperations, ...
14
A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence guided surgery in newly diagnosed glioblastoma patients
... Other critical point is the design of the vaccine schedule. Compared to previous DCs vaccination works in GBM, we began up-front immunotherapy prior to radiotherapy. During the usual 4-week interval between ...
12
Minimally Invaded Sentinel Lymph Node Model for the Development of Intraoperative Infrared Fluorescence Imaging
... After forepaw injection of IntegriSense680, the dye diffuses mainly through the lymphatic ducts, then reaches LNs where it accumulates momentarily before being eliminated (Figure 2(A)). The comparison between NIRF ...
11