IFN-gamma
<p>Activity Disease in SLE Patients Affected IFN-γ in the IGRA Results</p>
... that IFN-gamma levels are increased in subjects with active SLE and its levels positively corre- lates with a more severe phenotype of ...and IFN- γ, Th-2 cytokines IL-4, IL-5 and IL-10 and the Th-17 ...
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The role of IFN gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
... (and other cytokines) [15]. Moreover, IFN- γ secreted by Be1 cells and IL-4 secreted by Be2 cells, while presenting antigen to naïve T cells, regulated Th1 and Th2 develop- ment, respectively. In recognition of ...
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IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression
... In summary, there is a tendency of higher PD-L1 expres- sion in TP53 -mutated melanoma cells. One contributing factor might be an increased p53 expression level in these tumors. Indeed, while our analyses demonstrate ...
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MUC1 immunotherapy against a metastatic mammary adenocarcinoma model: Importance of IFN-gamma
... with IFN-γ and injected subcutaneously into BALB/c ...with IFN-γ expressed high levels of MHC class I molecules on 75% of tumour cells removed from the subcutaneous site on day 4 (data not shown), with 50% ...
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Differential IFN Gamma (IFN γ), Interleukin 10 (IL 10) and Cardiac Troponin I (cTnI) Responses in Natural Bovine Trypanosomosis in Nigeria
... We report for the first time in Nigeria the sera levels of cardiac troponin-I (cTnI) and cytokines (IFN-γ and IL-10) in natural bovine trypanosomoses. Elevation of cardiac troponin may be an indication of ...
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Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production
... NIPAM-hemin also induces the production of IFN- γ ; thus, we expected to observe NF- κ B activation by NIPAM-hemin in TLR9-expressing cells. However, our study demonstrated that NIPAM-hemin did not activate NF- κ ...
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Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells
... of IFN- γ in HCC cells, stable A20-knockdown (sh-A20) and negative control (sh-NC) cell lines were generated using HCC cell lines HepG2 and ...of IFN- γ (10, 20, 50 and 100 ng/mL) for 24 h or 100 ng/mL of ...
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IFN gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women
... and IFN-γ cytokine concentrations in pregnant women with a clinical diagnosis of ...and IFN -γ-1616 C/T (rs2069705) genotypes and alleles frequency, are associated with susceptibility to either uncompleted ...
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Polymorphism of IFN-γ+874T/A associated with production of IFN-γ affects human papillomavirus susceptibility in rural women from Luohe, Henan, China
... and IFN- γ R1 - 56 T/C and HPV susceptibility, adjusting for age, annual family income, education level, occupation and smoking status (Table ...of IFN- γ + 874T/A was associated with HPV susceptibility, ...
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IFN gamma potentiates atherosclerosis in ApoE knock out mice
... Atherosclerosis in apoE /IFN g R compound knockout mice. To evaluate atherosclerotic lesion development, a matched set of apoE 0 and apoE 0/IFN g R 0 mice was placed on a Western type diet (22). After 3 mo, ...
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AGM1+ spleen cells contain gamma interferon (IFN-gamma) gene transcripts in the early, sex-dependent production of IFN-gamma after picornavirus infection.
... Bigley, Viral Immunology, in press have found that the adherent cell population is necessary for IFN--y production by the AGM1+ cells in this virus-spleen cell culture system, that no tu[r] ...
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Recombinant interferon gamma augments phagocyte superoxide production and X chronic granulomatous disease gene expression in X linked variant chronic granulomatous disease
... interferon gamma (IFN-gamma) to ameliorate the physiologic defect of chronic granulomatous disease (CGD) by studying its effects on CGD phagocyte superoxide generation, NADPH oxidase kinetics, ...
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Inhibition by interferon gamma of human mononuclear cell mediated low density lipoprotein oxidation Participation of tryptophan metabolism along the kynurenine pathway
... (IFN gamma) of the early stages of low density lipoprotein (LDL) oxidation mediated by human peripheral blood mononuclear cells (PBMC) and monocyte-derived macrophages (MDM) in Ham's F-10 medium ...
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Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia
... In this study, we investigated the effects of cytokines (TNF- alpha, IL-1beta, and IFN-gamma) and LPS + IFN-gamma to induce temporal changes in cell morphology and induction of p-ERK1/2,[r] ...
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Role of QuantiFERON-TB Test in Detection of Children Infected with Mycobacterium tuberculosis
... (IFN) gamma in whole blood upon stimulation with specific ESAT6 and CFP-10 antigens of Mycobacterium tuberculosis has been introduced ...(9). IFN-gamma produced by T cells plays a critical ...
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Latent tuberculosis among pregnant mothers in a resource poor setting in Northern Tanzania: a cross sectional study
... Abbreviations AFB: Acid-fast bacilli; ANC: Ante-natal care clinic; CXR: Chest radiograph; DTLC: District TB and Leprosy Coordinator; IFN-gamma: Interferon gamma assay; LTBI: Latent TB in[r] ...
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Protein of Crimean Congo Hemorrhagic Fever Virus Induces Comparable
... potential for IFN-gamma induction in comparison to other N expressing constructs.. Cytokine responses in BALB/c mice sera. A) IFN-gamma response: Ad5-N construct was dominant in. 364[r] ...
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Ballester López, Carolina (2019): Novel players in COPD and their molecular implication in the disease immunopathology. Dissertation, LMU München: Medizinische Fakultät
... Interferon-gamma (r-IFN-gamma) induced activation of alveolar macrophages (AM) from anergic patients with chronic obstructive pulmonary disease (COPD). Cross-regulation of signaling path[r] ...
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Cryptococcal Interactions with the Host Immune System
... T cell-dependent activation of macrophages and enhancement of their phagocytic activity in the lungs of mice inoculated with heat-killed Cryptococcus neoformans: involvement of IFN-gamma[r] ...
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Incubation of Whole Blood at 39°C Augments Gamma Interferon (IFN-γ)-Induced Protein 10 and IFN-γ Responses to Mycobacterium tuberculosis Antigens
... antigen-dependent IFN- ␥ levels from 0.25 to 2.00 IU/ml and mitogen-induced IFN- ␥ levels from ...mitogen-induced IFN- ␥ levels from ...antigen-dependent IFN- ␥ response ...for IFN- ␥ ...
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