IGF axis
Exercise effects on adipokines and the IGF axis in men with prostate cancer treated with androgen deprivation: A randomized study
... Conclusions: Home-based exercise is correlated with positive changes in adipokine levels and the IGF-axis that may be related to healthy changes in physical fitness and body composition. While the ...
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Are diet prostate cancer associations mediated by the IGF axis? A cross sectional analysis of diet, IGF I and IGFBP 3 in healthy middle aged men
... Based on FFQ responses, and using standard food tables (The Royal Society of Chemistry and MAFF, 1991) and portion size data for men of this age (Ministry of Agriculture and Food, 1993), we estimated weekly consumption ...
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A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action
... Recently, PAPP-A enzyme activity has been shown to be inhibited by both STC1 and STC2 [29, 65]. To determine whether PAPP-A ac- tivity may be regulated by either of the STCs, we initially examined the expression of STC1 ...
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A Study Prevalence of Metabolic Syndrome in Patients with Acute Coronary Syndrome
... Framingham offspring study, mckewn et al 200412 Endocrine factors Hyperandrogenemia, polycystic ovarian syndrome, low total testosterone and SHBG levels, GH –IGF axis, glucocorticoid exc[r] ...
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The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis
... total IGF-I occur primarily as a result of the attenuated ...Furthermore, IGF-I and pro-inflammatory cytokines are disparately regulated, as inflammation leads amino acids away from muscle accretion and ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... both IGF-1R and insulin ...phosphorylated IGF-1R and its downstream pro- teins, including ERK and p70 s6k were all effectively inhib- ited by OSI-906 (OSI) ...HepG2. IGF-1R and insulin receptor ...
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Insulin-Like Growth Factor Axis Expression in Dental Pulp Cells Derived From Carious Teeth
... (IGF) axis plays an important role in dental tissue regenera- tion and most components of this axis are expressed in human dental pulp cells ...analyzed IGF axis gene expression in DPCs ...
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Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial.
... the IGF system as oncogenic signalling pathways and potential therapeutic target in advanced ...that IGF-1R could be a useful target in CRC therapy has been significantly challenged by the number of ...
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An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... endogenous IGF-1 and IGF-2 take effect through IGF-1R signaling, we were motivated to explore whether IL-6 could induce the secretion of IGF-1R ligands during ...as IGF-1 and ...
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Insulin-like growth factor - Oestradiol crosstalk and mammary gland tumourigenesis
... inhibited IGF action in BC cells [42, ...on IGF activity in BC cells ...bound IGF compared with free ...the IGF-1 induced desensitisation of IGF-1R and prolong the activity of growth ...
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Assessment of Growth and Its Regulation through Insulin-like Growth Factor-I in Southern flounder, Paralichthys lethostigma
... circulating IGF-I is derived from hepatic production (Yakar et ...plasma IGF-I and hepatic IGF-I mRNA levels in mammals and various fish, including tilapia (Uchida et ...regulates IGF-I ...
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Insulin like growth factor I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis
... involving IGF-I in mind we can speculate the use of IGF-I to stimulate healing and control of inflammation in chronic and se- vere cases of ATL where IGF-I level is ...on IGF-I use in other ...
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Regulation of experimental autoimmune encephalomyelitis with insulin like growth factor (IGF 1) and IGF 1/IGF binding protein 3 complex (IGF 1/IGFBP3)
... free IGF-1 or IGF-1/IGFBP3 alone, mildly enhanced proliferation in the absence of antigen, it was not sufficient to activate most encephalitogenic precursors in vitro, based on disease-induc- ing effect ...
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Reproductive and metabolic endocrinology in rams selected for high or low plasma IGF 1 concentrations : a thesis presented in partial fulfilment of the requirements for the degree of Master of Animal Science at Massey University
... of iGF-1 selection line and season on scrotal circumference ...of IGF-1 selection line and season on sperm motility and sperm density Experiment 1 ...
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Assessing the feasibility of injectable growth-promoting therapy in Crohn’s disease
... GH/IGF-1 axis, the possible use of other forms of growth- promoting agents such as rhIGF-1, either alone or in combination with rhGH for promoting growth, also war- rants further ...serum IGF-1 ...
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Elevated insulin like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
... To prepare cell lysates for Western blot analysis, cells were washed three times with ice-cold PBS and lysed on ice for 30 minutes with lysis buffer (50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM ethylenediaminetetraacetic acid, ...
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Modulation of IGF-I Receptor Activation by the IGF-I peptides
... Endodontics is the branch of dentistry that is responsible for the safety and the health of the dental pulp, and the therapeutic replacement for irreversible damage like necrosis or irreversible inflammation. To date ...
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Synergy Between Insulin-Like Growth Factor-I (igf-I) E-Peptides and Igf-I Signaling Alters Growth in Skeletal Muscle
... of IGF-IA (IA, containing E- peptide A), IGF-IB (IB, containing E-peptide B) and IGF-IStop (ISt, stop codon after IGF-I, no ...mature IGF-I boundaries. V44M mutation is within the ...
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Autocrine IGF I/insulin receptor axis compensates for inhibition of AKT in ER positive breast cancer cells with resistance to estrogen deprivation
... including IGF-IR, InsR, HER3 and FGFRs. Inhibition of IGF-IR/InsR or PI3K abrogated AKT PH-GFP membrane localization and AKT phosphor- ylation following treatment with ...FoxO-dependent IGF-IR, ...
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The Insulin-like Growth Factor Binding Protein Superfamily: New Perspectives
... for IGF-I and IGF-II in a variety of biologic ...protect IGF pep- tides from degradation and clearance, increase the half- life of the IGFs, and deliver them to appropriate tissue ...of IGF ...
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